Stephen Rapp Email & Phone Number

West Lafayette, IN, US

Serves as the primary point of contact for Study Sponsors to enable the design, development and completion of study protocols and insures successful completion of all study activities while meeting all required time lines. Duties include study scheduling and monitoring of inlife and all other study-related activities, review of IACUC protocols, resource.

Responsible for leading the In-Life Group to insure scientifically sound execution of in vivo pharmacokinetic, toxicology and pharmacology studies. Key activities include providing scientific and technical input to Study Directors during study protocol generation, assisting Study Coordinators in timely communication with Principle Investigators or Study.

New York, New York, US

Managed drug development pharmacology teams that delivered critical data required for endorsement and initiation of Phase 2 clinical trials to support atherosclerosis, liver fibrosis and pulmonary arterial hypertension therapeutic areasLed multi-disciplined, cross-site in vivo pharmacology teams and generated efficacy, biomarker and pk/pd data required for.

Leader of drug development pharmacology team that delivered robust drug efficacy, biomarker and safety data demonstrating utility of a novel anti-thrombotic agent, critical to endorsement of Phase 1 clinical trials. Established in vivo pharmacology thrombosis and in vitro platelet aggregation lab and generated key translational pharmacology data. Authored.

Led drug development pharmacology team that implemented multiple clinically relevant preclinical animal models of hypercholesterolemia and atherosclerosis and identified a drug candidate that progressed to human Phase II clinical testing. Developed a high-throughput fecal bile acid assay and compound screening model. Developed and implemented animal models.

Established multiple in vitro models of leukocyte adhesion, chemotaxis and diapedesis studies. Established in vitro models of drug absorption models utiliziing commercially available cell lines and primary cell lines generated from bovine brain endothelium, rodent and human upper respiratory tissue. Established in vitro cell culture models utilizing.

Performed cell fusions and clone selection, generated monoclonal antibodies to human colon cancer antigens. Conjugated Mab to imaging agent, approved by FDA for colon cancer detection.

CNS/PNS primary cell culture model development to investigate neuronal plasticity, regeneration and cell signaling.