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Accomplished immunologist with extensive knowledge of T cell engineering and a thorough understanding of molecular biology. Ten years of experience in the fields of immunotherapy and vascular disruption therapy, with an emphasis on the design and evaluation of T cells bearing chimeric antigen receptors. An effective leader and collaborative team member, with a proven ability to move multiple projects forward to publication. A highly articulate public speaker with strong written and interpersonal communication skills. A valued member of the laboratory, who is quick to learn and adaptable across multiple scientific disciplines in both academic and industry settings.Specialties: Chimeric Antigen Receptors (CARs), Adoptive T-cell Therapy, Immunotherapy, Synthetic Biology, Stromal Immunobiology, Vascular Therapy, Analytical Chemistry
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Senior Director, Translational SciencesArsenalbio Jan 2023 - PresentSouth San Francisco , Ca, UsResponsibilities include: assay establishment, clinical trial sample management, and translational data analysis, interpretation, and communication of results.
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Senior Director, Ict DevelopmentArsenalbio Aug 2021 - Apr 2023South San Francisco , Ca, UsEstablished ArsenalBio's pipeline development team, a group consisting of multiple product team leads devoted to internal as well as external partnered programs. Initiated work on a future pipeline program that includes a novel module not previously developed at Arsenal. Ensured existing pipeline programs met essential company deadlines without compromising data integrity.
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Director, Cell TherapyArsenalbio Aug 2019 - Aug 2021South San Francisco , Ca, UsEstablished the preclinical development team at ArsenalBio prior to taking on the role of product team lead for ArsenalBio's first clinical product, AB-1015. AB-1015 consists of a logic gate against alkaline phosphatase, germ-line (ALPG) and mesothelin (MSLN), as well as an shRNA module that knocks down two key regulators of T cells function, FAS and PTPN2. As product team lead, I oversaw the research and development of each of these modules, as well as their integration into a final drug product cassette. The AB-1015-101 clinical trial began in January, 2023.
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DirectorKite Pharma Jan 2019 - Aug 2019Santa Monica, California, UsOversaw an eleven-member team responsible for the preclinical development of CAR T drug products for multiple myeloma and acute myeloid leukemia, resulting in the filing and approval of one investigational new drug (IND) application. Was responsible for developing a multi-year research strategy, including next generation approaches, for both indications. Managed cross-functional teams located in San Francisco as well as Los Angeles. -
Senior ScientistKite Pharma Jan 2018 - Dec 2018Santa Monica, California, UsDirected Kite's multiple myeloma research efforts, including the development of novel CAR therapies aimed to improve upon existing anti-BCMA CAR therapies. Developed and implemented a three year research plan, while simultaneously overseeing a team of research associates and scientists that conducted numerous activities including antigen validation, antibody discovery, and CAR T cell functional assessment both in vitro as well as in vivo. Developed a novel drug-inducible switch platform to enable control of CAR T cell function using a small molecule activator.
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Scientist IiCell Design Labs Jul 2017 - Jan 2018Co-led Cell Design Lab's drug-inducible CAR T cell program. Aided in the establishment of key organizational infrastructure such as the molecular biology group, vector core, and in vivo pharmacology group. Presented scientific discoveries and relevant drug development strategies during partnership discussions, which culminated in the acquisition of CDL by Kite Pharma.
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ScientistCell Design Labs Jun 2016 - Jul 2017Established a four-person scientific team responsible for developing drug-inducible CAR T cells to address on-target toxicities associated with CAR T cell therapy, such as cytokine release syndrome. Designs included an “ON-switch” CAR, which consisted of two protein domains that would dimerize and signal only in the presence of ligand.
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Postdoctoral ResearcherGenentech Nov 2014 - 2016South San Francisco, California, UsInterrogated the interaction of immune cells with the tumor microenvironment, specifically the tumor stroma, using confocal and intra-vital imaging. Examined the underlying mechanisms by which the tumor stroma and associated microenvironment influences anti-tumor immunity with the purpose of augmenting these interactions to make the tumor microenvironment more inflammatory. -
Graduate Student In Cell And Molecular BiologyUniversity Of Pennsylvania Sep 2008 - Oct 2014Philadelphia, Pa, UsProjects aimed at understanding the interaction of chimeric antigen receptor (CAR) T cells with the tumor vasculature. Helped to elucidate the suppressive role of FASL on the tumor endothelium in ovarian cancer. Developed an anti-PSMA CAR and characterized the ability of these CAR T cells to disrupt the tumor vasculature and elicit an anti-tumor response. -
Mercury AnalystFrontier Geosciences Dec 2006 - May 2008Analyzed water, tissue, and soil samples for trace mercury and methyl mercury content using cold vapor atomic fluorescence spectroscopy. Additional duties included analysis of arsenic and chromium, as well as sample preparation for all analyses.
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Research AssistantNoaa Jul 2004 - Aug 2005Washington, Dc, UsOversaw quality control and lab manager duties for the carbon cycle greenhouse gas group at NOAA. Maintained a network of over 5000 air sampling vessels and coordinated global distribution of the flasks and sampling units. Upon return of the flasks, the air samples were analyzed for gases including CO2, Methane, etc.
Stephen Santoro Skills
Stephen Santoro Education Details
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University Of PennsylvaniaGene Therapy And Vaccines -
University Of Colorado BoulderAnd Developmental Biology And Geology
Frequently Asked Questions about Stephen Santoro
What company does Stephen Santoro work for?
Stephen Santoro works for Arsenalbio
What is Stephen Santoro's role at the current company?
Stephen Santoro's current role is Senior Director, Translational Sciences at ArsenalBio.
What is Stephen Santoro's email address?
Stephen Santoro's email address is sa****@****ail.com
What is Stephen Santoro's direct phone number?
Stephen Santoro's direct phone number is +150883*****
What schools did Stephen Santoro attend?
Stephen Santoro attended University Of Pennsylvania, University Of Colorado Boulder.
What skills is Stephen Santoro known for?
Stephen Santoro has skills like Molecular Biology, Cell Culture, Cell, Cell Biology, Analytical Chemistry, Science, Flow Cytometry, Tissue Culture, Lifesciences, Western Blotting, Elisa, Laboratory.
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