Stephen Cranwell Email & Phone Number

Cambridge, GB

My research currently focuses on cell non-autonomous effects of the senescence-associated secretory phenotype on the proteostasis quality control network using novel systems.

London, England, United Kingdom

During Oct-Dec I tutor small groups of students (undergraduate and postgraduate) for Professor David Gems Biology of Ageing course at University College London.

London, England, United Kingdom

Building on the finding that RNA Polymerase III inhibition extends lifespan downstream of TOR, my project investigated what transcription factors mediate the above lifespan extension. The project involved knocking down key transcription factors via RNAi using a modified GAL4-UAS system. The project will entailed a bioinformatics aspect to investigate the.

As a senior analyst in the immunobiology group, I worked to support pre-clinical and clinical safety and efficacy testing of gene therapies. Using qPCR and RT-qPCR, I assessed viral vector biodistribution, as well as mRNA and miRNA expression changes as a result of dosing or toxicity. My time at Charles River allowed me to gain a deeper understanding of.

My postgraduate research project investigated the enzyme capacity of exosomes. I chose to undertake this project as I was intrigued by the emerging evidence these vesicles could contain oncogenic messengers. There had also been recent studies indicating their role in senescence and their increased release in concert with the SASP. As well as uncovering new.

My final year undergraduate project investigated the role of a heat shock proteins influence on drought response in the model organism Arabidopsis thaliana. I investigated whether a knockout variation produced an altered drought tolerance phenotype. This introduced me to a number of standard techniques that I was able to perform routinely with success.

During the summer of 2013 I worked at Oceanlab, an institute of the University of Aberdeen. Working there gave me experience in science outside of the lab. Here I learned to program with R and Brodgar and analyse decades of survey data from fisheries by completing data exploration and performing generalised additive modelling. I also wrote progress reports.

In the year between school and university I worked full time as a lab assistant at the John Innes Centre, an independent, international centre of research in plant science and microbiology. I learnt many skills including laboratory safety and methods such as PCR, gel electrophoresis, and DNA isolation. I also worked with fluorescent microscopes, attended.

Doctor Of Philosophy - Phd, Molecular Biology

Mres, Biology Of Ageing, Distinction

Master Of Science (Msc), Biotechnology, Distinction

Modules: Stem Cells and Regenerative Medicine Tools for Synthetic Biology Intelligent Agriculture Environmental Gene Mining and.

Bachelor Of Science (Bsc), Genetics, 1

Activities and Societies: Marine Conservation Society, Languages for All, Diving Club (SubAqua) 3rd Year: Research Project Issues in.

Education record