Stephen Helliwell work email
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Board director, observer, CEO / CSO / VP level biotech executive with company building experience, and 19+ years of pre-clinical research and development experience, from novel target identification approaches to PK / PD / efficacy studies. Extensive experience leading and influencing interdisciplinary internal project teams across a globally matrixed organization, and in translating discoveries from Academia into meaningful projects. Demonstrated track record of innovative high complexity phenotypic screening approaches for both target and lead identification using yeast, cell lines, patient-derived cells, stem cells and differentiated neurons, and complex primary human multicellular liver disease models.Mitochondria - Mitophagy - Liver - Kidney - Transplant - Fibrosis - Ischemic Reperfusion Injury - Rare Disease - Parkinson's - Monogeneic Disease - Aging - Longevity - Telomere - Longevity - Senescence
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Chief Scientific OfficerCellvie Apr 2023 - PresentZuerich, Ch -
Expert For InnosuisseInnosuisse Jan 2023 - PresentBern, Ch -
Member, Board Of DirectorsRejuveron Telomere Therapeutics Oct 2022 - May 2023
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Member Board Of DirectorsRejuveron Vascular Therapeutics Ag Jul 2022 - Jan 2023 -
Board ObserverRejuvenate Biomed Oct 2021 - Jan 2023 -
Member, Board Of DirectorsRejuveron Senescence Therapeutics Jul 2020 - Jan 2023Rejuveron Senescence Therapeutics AG is a biotech company focused on immune-mediated clearance of senescent cells. -
Vice President Discovery BiologyRejuveron Life Sciences Ag May 2020 - Jan 2023Schlieren, Zurich, ChRejuveron Life Sciences AG is a company that develops and invests in drugs and technologies which have the potential to improve the health of our aging population. We aim to find cures for age-related diseases and advance science & technology to help people live longer, healthier lives. -
Senior Investigator At Novartis Institutes For Biomedical ResearchNovartis Jan 2017 - May 2020Basel, Baselstadt, ChDisease Area X - Liver Disease.Developing complex multicellular non-alcoholic steatohepatitis (NASH) with fibrosis models for phenotypic screening, both in house and in collaboration with external groups. Lead global project teams into PK/PD/efficacy studies for NASH. -
Senior Investigator At Novartis Institutes For Biomedical ResearchNovartis Mar 2010 - May 2020Basel, Baselstadt, ChMitochondria Hub leaderInitiated and lead program for diseases connected to Mitochondrial dysfunction including aging (Helliwell, 2016). Driving multiple projects utilising a wide variety of approaches to chemically and genetically dissect pathways related to mitochondrial biology to elucidate novel pathway nodes for intervention in e.g. Parkinson's Disease (Dowdle et al 2015, Filipuzzi et al 2017, Potting et al 2017).
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Research Investigator / Lab Head, Developmental And Molecular PathwaysNovartis Feb 2005 - Feb 2010Basel, Baselstadt, ChResearch Investigator (Lab Head), Developmental & Molecular Pathways.Developing and implementing chemical and genetic screens using model organisms to elucidate compound modes of action and to discover novel targets and leads. Experimental design, PoC and HTS assay development and implementation for disease target specific assays (Hoepfner et al 2012, 2014; Sadlish et al 2013; Shimada et al 2013; Rispal et al 2015; Helliwell et al 2015, Petrovic et al 2017).Collaborating with Novartis Scientists of diverse disciplines to advance high visibility therapeutic drug discovery programs.
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Junior Group Leader, Lecturer, BiozentrumUniversity Of Basel Feb 2002 - Jan 2005Basel, ChCoordinated research projects to understand environmentally regulated membrane protein sorting in yeast. Collaborated with ETH Zürich group to perform / improve robotic genetic screens. Completed projects in collaboration with Cambridge University group (Bowers et al., 2004), Biozentrum group (Crespo, et al., 2004), and Virginia University group (Devayasham et al., 2006). Peer reviewer – Mol. Cell, J. Cell Biol., Mol. Biol. Cell., EMBO J., EMBO rep. -
Post-Doctoral FellowMit Aug 1998 - Jan 2002Cambridge, Ma, UsPost-Doctoral Fellow with Professor Chris A. Kaiser.Developed genetic, cell biological and biochemical approaches to elucidate molecular mechanisms of membrane protein sorting in yeast. Demonstrated a novel role for poly-ubiquitination in Golgi to endosome sorting. Discovered proteins which regulate poly-ubiquitination (Helliwell et al., 2001). -
Post Doctoral FellowUniversity Of Bern Mar 1997 - Jun 1998Bern, ChElucidated the link between protein synthesis and the cell cycle using molecular biology and genetics (Danaie et al., 1999). Conducted medical student teaching seminars.
Stephen Helliwell Skills
Stephen Helliwell Education Details
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University Of BaselBiochemistry -
University Of KentBiochemistry
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Cheadle Hulme SchoolPhysics
Frequently Asked Questions about Stephen Helliwell
What company does Stephen Helliwell work for?
Stephen Helliwell works for Cellvie
What is Stephen Helliwell's role at the current company?
Stephen Helliwell's current role is Life Science / Biotech CSO.
What is Stephen Helliwell's email address?
Stephen Helliwell's email address is st****@****tis.com
What schools did Stephen Helliwell attend?
Stephen Helliwell attended University Of Basel, University Of Kent, Cheadle Hulme School.
What skills is Stephen Helliwell known for?
Stephen Helliwell has skills like Cell Biology, Molecular Biology, High Throughput Screening, Drug Discovery, Assay Development, Biochemistry, Life Sciences, Yeast, Lifesciences, Laboratory, Chemical Biology, Compound Screening.
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