Steve Mathias Email & Phone Number

Albuquerque, Nm, Us

Albuquerque, New Mexico

Translational Informatics is a Division within the Department of Internal Medicine that offers services to both industry and academia such as chemical, biological and biomedical knowledge mining support and prediction by means of cheminformatics, bioinformatics and clinical informatics software and technologies. I am the principal staff scientist responsible for database application development and support of bioinformatics and genomics software.Designed, developed and supported several… Show more Translational Informatics is a Division within the Department of Internal Medicine that offers services to both industry and academia such as chemical, biological and biomedical knowledge mining support and prediction by means of cheminformatics, bioinformatics and clinical informatics software and technologies. I am the principal staff scientist responsible for database application development and support of bioinformatics and genomics software.Designed, developed and supported several scientific database applications, including: CARLSBAD, an integrated bioactivity database and web application; Roadrunner, a chemical database application supporting the New Mexico Molecular Libraries Screening Center; Genotation, a genomics workbench, the core of which is an extensive integrated database of gene annotation data; and UNMMD, database application for the storage, management and analysis of spotted microarray data.Provided informatics support and services in numerous research collaborations.Installed and maintained numerous bioinformatics databases and software packages to support genomics research within the Health Sciences Center.Managed Linux servers on which the above services were made available. Show less

Worked with the Database Group on developing data integration and warehousing strategies. Developed object models, database schemas, web services, and the user interface for the GenomeDW project.

Principal staff scientist for product development in the areas of genetic analysis and pharmacogenomics. Reported to the President and Chief Scientist. Defined the scientific content and served on the product steering teams for LinkMapper, dmCORE, and dmGENETICS. Developed and maintained the domain object model supporting all products developed on the Java/Oracle platform. Developed a Perl software development kit including an API to the Genomica domain object model, used this toolkit to… Show more Principal staff scientist for product development in the areas of genetic analysis and pharmacogenomics. Reported to the President and Chief Scientist. Defined the scientific content and served on the product steering teams for LinkMapper, dmCORE, and dmGENETICS. Developed and maintained the domain object model supporting all products developed on the Java/Oracle platform. Developed a Perl software development kit including an API to the Genomica domain object model, used this toolkit to build prototype applications, and applied it to research-oriented data management and analysis. Show less

Developed and supported specialist bioinformatics tools and resources to support genomics-based research in the Biopharmaceutical Department. Built a web-client based database application used by lab-based scientists to manage in house SNP discovery data. Developed a high-throughput system for the characterization of sequences for use in the production of DNA microarrays for gene expression analysis. Received an R&D Impact Award for this project. Developed Perl libraries, used for the… Show more Developed and supported specialist bioinformatics tools and resources to support genomics-based research in the Biopharmaceutical Department. Built a web-client based database application used by lab-based scientists to manage in house SNP discovery data. Developed a high-throughput system for the characterization of sequences for use in the production of DNA microarrays for gene expression analysis. Received an R&D Impact Award for this project. Developed Perl libraries, used for the above projects and by others in the bioinformatics department, to automate database searching and sequence annotation. Show less

Applied of state of the art bioinformatics methods to data mining of proprietary and public EST and genomic sequence databases for novel drug targets. Patented several novel gene sequences as drug targets in the therapeutic areas of diabetes and obesity. Developed programs for the automation of database searching and sequence annotation activities. These programs were used on a daily basis by the investigators in the Gene Informatics group. Worked closely with chemists and wet-bench… Show more Applied of state of the art bioinformatics methods to data mining of proprietary and public EST and genomic sequence databases for novel drug targets. Patented several novel gene sequences as drug targets in the therapeutic areas of diabetes and obesity. Developed programs for the automation of database searching and sequence annotation activities. These programs were used on a daily basis by the investigators in the Gene Informatics group. Worked closely with chemists and wet-bench biologists to effectively prioritize the discovery efforts of the Gene Informatics group to the needs of the therapeutic areas. Show less

Ph.D., Human Genetics And Molecular Biology

Bs, Biochemistry

Activities and Societies: Honors Program Phi Beta Kappa