Steve Darnell Email and Phone Number
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Principal scientist performing directorial responsibilities. Specialized in structure-based and computational protein design. Skilled at leveraging scientific creativity to bring new antibody discovery technologies and software to market. Strategist who is broadening corporate vision to pivot toward establishing a service oriented antibody discovery and biotherapeutics developability platform. Expertise in establishing impactful projects in domains new to the business and leading high-performance teams to complete those project goals.Highlights• Bioinformaticist grounded in biochemistry: mastery of understanding the structure-function relationship and its application in successful protein design; years of practical laboratory experience coupled with a formal education in mathematics, computer science, and biocomputing.• Championed the construction of a protein modeling and antibody design suite by establishing its scientific vision, leading the development efforts, securing external grant funding, and maintaining multiple years of corporate support to establish this new product line.• Spearheading an ab initio antibody discovery initiative that combines biophysics and machine learning to mimic the immune system’s antibody selection and optimization process, culminating in the experimental expression, purification, and binding characterization of antibody drug candidates.
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Principal ScientistBoehringer Ingelheim Jul 2024 - PresentIngelheim Am Rhein, Rhineland-Palatinate, DeMember of the Computational Biology & Bioinformatics group. I'm eager to apply my skills in computational biology, protein modeling, and software development to accelerate molecular designs within the Lead Engineering group. Exciting things are coming!
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Principal ScientistDnastar Jul 2017 - Jul 2024Madison, Wisconsin, Us• Principal investigator of DNASTAR’s structural bioinformatics research.• Primary grant writer securing $8 million in Small Business Innovation Research (SBIR) funding.• Scientific and market specialist for the business development group and technology acquisition team.• Responsible for the strategy, roadmap, and feature definition of the structural biology product line.• Team lead and founding member of the structural biology development group (founded 2010, 2-8 members depending on business needs).• Product manager for Protean 3D (molecular visualization), NovaFold (structure prediction), NovaFold Antibody (antibody structure prediction), NovaDock (protein-protein docking), Protein Design (protein engineering), and NovaCloud (structural biology services on Amazon Cloud).• Product architect for Linux-container (Docker) and cloud-based software deployment.• Liaison with owners, board members, scientific collaborators, sales staff, and customers.• Evaluator of new software and hardware technology for future commercialization (e.g. deep learning, hardware acceleration, mixed reality, distributed cloud computing).• Developed machine learning models to predict glycosylation sites and B cell epitopes in protein sequences and 3D structures.• Developed machine learning models to predict the best complementary-determining region (CDR) loop 3D conformations for antibody homology models• Continuing duties from Senior Scientist role. -
Senior ScientistDnastar Jan 2013 - Jun 2017Madison, Wisconsin, Us• Project lead for NovaFold, DNASTAR's 3D protein structure prediction program, since its origin in 2012.• Negotiate commercial software licenses for bioinformatics research algorithms.• Write small business grant applications for structural bioinformatics-based software products.• Continuing duties from Scientist role.
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ScientistDnastar May 2009 - Dec 2012Madison, Wisconsin, Us• Provide expertise in structural and computational biology in support of new products and product design.• Scientific lead for integrating sequence analysis and structure prediction to create structural analysis tools suitable for both molecular and structural biologists. • Project lead for Protean 3D, DNASTAR’s molecular visualization program, since its origin in 2010.
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Research AssociateUniversity Of Wisconsin-Madison Oct 2008 - Apr 2009Madison, Wi, Us• Applied computational biology tools to cancer research problems.• Implemented virtual screening of millions of compounds to enrich prediction of protein binding inhibitors.• Optimized a high-throughput binding assay to screen thousands of small molecules for binding inhibition. -
Research AssistantUniversity Of Wisconsin-Madison Sep 2003 - Sep 2008Madison, Wi, Us• Thesis: “Protein Interaction Hot Spots and Engineered Binding Affinity within the Smad4-Ski Interface.”• Developed machine learning models to predict binding hot spots in 3D protein-protein interfaces.• Implemented a public web server to provide automated access to these models.• Applied positive and negative design principles to predict site-directed mutations that improve and disrupt binding affinity within a protein-protein complex.• Cloned and purified recombinant variants, developed a quantitative binding assay, and validated designs by demonstrating statistically significant increases in binding affinity.
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Research TechnicianMedical College Of Wisconsin Jun 2002 - Aug 2003Wi, Us• Purified site-directed mutants for spin-label studies to determine protein domain movements.• Optimized the purification of a recombinant integral membrane protein. -
Student ResearchUniversity Of Wisconsin-Madison Aug 2000 - May 2002Madison, Wi, Us• Purified site-directed mutants to probe an unknown enzyme mechanism.• Presented group and poster presentations.
Steve Darnell Skills
Steve Darnell Education Details
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University Of Wisconsin-MadisonBiochemistry (Minor In Computer Science) -
University Of Wisconsin-MadisonChemistry
Frequently Asked Questions about Steve Darnell
What company does Steve Darnell work for?
Steve Darnell works for Boehringer Ingelheim
What is Steve Darnell's role at the current company?
Steve Darnell's current role is Principal Scientist, Biotherapeutics at Boehringer Ingelheim.
What is Steve Darnell's email address?
Steve Darnell's email address is da****@****tar.com
What is Steve Darnell's direct phone number?
Steve Darnell's direct phone number is +160825*****
What schools did Steve Darnell attend?
Steve Darnell attended University Of Wisconsin-Madison, University Of Wisconsin-Madison.
What skills is Steve Darnell known for?
Steve Darnell has skills like Bioinformatics, Computational Biology, Protein Chemistry, Biochemistry, Sequence Analysis, Algorithms, High Throughput Screening, Pcr, Protein Purification, Western Blotting, Protein Engineering, Assay Development.
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