Steven Mathieu Email and Phone Number
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Self motivated and goal oriented process research chemist with extensive experience in both lab and plant production in the area of pharmaceutical drug development. Excellent lab skills on both lab and kilo lab scale syntheses. Independent worker with strong technical, observation, analysis, and problem solving skills, presenting clear and accurate results in reports and presentations. Very competent at multi-tasking with good time management skills. Team oriented researcher with strong communication and interpersonal skills. Organic synthesis and process R & D experience in nucleosides / nucleotides / oligonucleotides (PMOs), natural products, macrocycles, and heterocycles.Technical Skills: • Reaxys, Sci-Finder, Excel, Microsoft Word, Power Point, Chemdraw, ISIS Draw, ELN, and D360.• NMR, IR, HPLC, GC, LC/MS, React IR, XRD, KF, H-Cube, Crystal 16, and Lasentech crystallization optimization.• Established robust synthetic processes translatable from lab scale to kilo-lab to plant scale.• Developed and performed recrystallization and trituration processes to isolate high quality intermediates and products.• Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes• Experienced with kilo-lab scale equipment (12 L to 50 L reaction size vessels) and proper lab safety.• Performed reverse-phase and normal-phase chromatography based on TLC results with automated and non-automated biotage systems (4 g to 5 kg silica cartridges).• Supervised pilot plant campaigns to produce GLP tox and GMP quality material.• Transferred technical packages to local (pilot plant) and global CMC partners.
Biogen
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Senior Scientist - Chemical Process DevelopmentBiogen Aug 2022 - PresentCambridge, Ma, Us -
Scientist Ii - Chemical Process DevelopmentBiogen May 2019 - Aug 2022Cambridge, Ma, Us -
Contract Scientist I - Chemical Process DevelopmentBiogen Aug 2018 - May 2019Cambridge, Ma, Us -
Senior Principal Researcher - Integrated Chemistry GroupEisai Us Dec 2013 - Aug 2018Nutley, Nj, Us- Accelerated high priority Immuno-Oncology project timeline by assisting in early development work on lead compounds, providing API supply for pivotal MTD/DRF & GLP-Tox studies, synthesizing GMP starting material and assisted in tech transfer to global CMC partner to prevent delay in production of clinical API.- Assisted in the early development work for the IND candidate H3B-8800 on both lab and kilo lab scale.- Established robust synthetic processes translatable from lab scale to kilo lab scale on multiple projects.- Contributed to the work in the patent (WO 2017/024264) by synthesizing all 50 stereopure Phosphorodiamidate Morpholino Oligonucleotide (PMO) dinucleotide combinations from early and late eluting prep HPLC chiral purified monomers. - Multiple medicinal chemistry project experience: Hit-to-lead and lead optimization library synthesis for SAR development; Improved potency, physchem and ADME properties as well as resolved PgP issues; and Accelerated go / no go decisions to achieve or exceed milestone timelines.- Carried out syntheses on milligram to kilogram scale (4 – 22 steps). -
Senior Principal Researcher- Process ResearchEisai Us May 2011 - Dec 2013Nutley, Nj, Us- Established and developed a robust synthetic process translatable from lab scale to kilo lab to pilot plant scale for the IND candidate Tazemetostat/E7438.- Carried out tech transfer packages to local (pilot plant) and global CMC partners.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers.- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes.- Authored accurate and detailed experimental procedures and batch records -
Principal Researcher - Process ResearchEisai Us Jul 2007 - May 2011Nutley, Nj, Us- Assisted in the development, scale up synthesis and tech transfer of the 2nd generation Halaven® C14-26 fragment from D-quinic acid.- Developed robust synthetic processes translatable from lab scale to kilo lab to pilot plant for the IND candidate Cedazuridine/E7727.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers- Developed processes for Crystallization-induced diastereoselective transformation (CIDT) and chemical resolution for stereocontrolled manufacturing- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes- Technical transfer packages to local (pilot plant) and global CMC partners- Collaborated with medicinal chemists via early involvement leading to timely solutions for CMC challenges.- Performed Chemical Hygiene Officer role for process research group for multiple years.- Authored accurate and detailed experimental procedures and batch records -
Senior Research Associate- Process ResearchIdenix Pharmaceuticals Sep 2006 - Jul 2007- Assisted in the early development of IDX184.- Carried out lab scale experiments which were then translatable to kilo lab scale.
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Research Associate- Process ResearchIdenix Phamaceuticals May 2002 - Sep 2006- Developed reproducible industrial scale processes for HCV (NM283 - nucleoside) and HIV (IDX899 - chiral phosphoindole)- Carried out milligram to kilogram scale (4 -14 steps)- Assisted in the management of hazardous chemical waste
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Research ChemistPharm-Eco - A Johnson Matthey Company Aug 2001 - May 2002- Assisted on projects in medicinal and process chemistry meeting all deadlines.- Synthesized, isolated and improved the syntheses of various high quality drug analogs- Carried out gram to milligram scale, multiple step syntheses shipped to client for SAR screening.
Steven Mathieu Skills
Steven Mathieu Education Details
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University Of New HampshireChemistry -
Saint Anselm CollegeChemistry
Frequently Asked Questions about Steven Mathieu
What company does Steven Mathieu work for?
Steven Mathieu works for Biogen
What is Steven Mathieu's role at the current company?
Steven Mathieu's current role is Self motivated and goal oriented process research chemist with extensive experience in lab scale to plant production.
What is Steven Mathieu's email address?
Steven Mathieu's email address is st****@****hoo.com
What schools did Steven Mathieu attend?
Steven Mathieu attended University Of New Hampshire, Saint Anselm College.
What skills is Steven Mathieu known for?
Steven Mathieu has skills like Chemistry, Organic Synthesis, Process Research, Organic Chemistry, Lc Ms, Chromatography, Nmr, Mass Spectrometry, Drug Discovery, Hplc, Medicinal Chemistry, Uv/vis.
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