Senior Scientist - Chemical Process Development
Current
Aug 2022 - Present
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Steven Mathieu Email & Phone Number
Senior Scientist - Chemical Process Development
at
Biogen
1 work email found
@biogen.com
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✓ Verified Jul 2026
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Current company
Role
Senior Scientist - Chemical Process Development
Location
Greater Boston, United States
Who is Steven Mathieu? Overview
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Quick answer
Steven Mathieu is listed as Senior Scientist - Chemical Process Development at Biogen, based in Greater Boston, United States. AeroLeads shows a work email signal at biogen.com and a matched LinkedIn profile for Steven Mathieu.
Steven Mathieu previously worked as Scientist II - Chemical Process Development at Biogen and Contract Scientist I - Chemical Process Development at Biogen. Steven Mathieu holds Ms, Chemistry from University Of New Hampshire.
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{first}.{last}@biogen.com
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Profile bio
About Steven Mathieu
Self motivated and goal oriented process research chemist with extensive experience in both lab and plant production in the area of pharmaceutical drug development. Excellent lab skills on both lab and kilo lab scale syntheses. Independent worker with strong technical, observation, analysis, and problem solving skills, presenting clear and accurate results in reports and presentations. Very competent at multi-tasking with good time management skills. Team oriented researcher with strong communication and interpersonal skills. Organic synthesis and process R & D experience in nucleosides / nucleotides / oligonucleotides (PMOs), natural products, macrocycles, and heterocycles.Technical Skills: • Reaxys, Sci-Finder, Excel, Microsoft Word, Power Point, Chemdraw, ISIS Draw, ELN, and D360.• NMR, IR, HPLC, GC, LC/MS, React IR, XRD, KF, H-Cube, Crystal 16, and Lasentech crystallization optimization.• Established robust synthetic processes translatable from lab scale to kilo-lab to plant scale.• Developed and performed recrystallization and trituration processes to isolate high quality intermediates and products.• Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes• Experienced with kilo-lab scale equipment (12 L to 50 L reaction size vessels) and proper lab safety.• Performed reverse-phase and normal-phase chromatography based on TLC results with automated and non-automated biotage systems (4 g to 5 kg silica cartridges).• Supervised pilot plant campaigns to produce GLP tox and GMP quality material.• Transferred technical packages to local (pilot plant) and global CMC partners.
Listed skills include Chemistry, Organic Synthesis, Process Research, Organic Chemistry, and 39 others.
Current workplace
Steven Mathieu's current company
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9 roles
Steven Mathieu work experience
A career timeline built from the work history available for this profile.
Scientist Ii - Chemical Process Development
May 2019 - Aug 2022
Contract Scientist I - Chemical Process Development
Aug 2018 - May 2019
Senior Principal Researcher - Integrated Chemistry Group
- Accelerated high priority Immuno-Oncology project timeline by assisting in early development work on lead compounds, providing API supply for pivotal MTD/DRF & GLP-Tox studies, synthesizing GMP starting material and assisted in tech transfer to global CMC partner to prevent delay in production of clinical API.- Assisted in the early development work for the IND candidate H3B-8800 on both lab and kilo lab scale.- Established robust synthetic processes translatable from lab scale to kilo lab scale on multiple projects.- Contributed to the work in the patent (WO 2017/024264) by synthesizing all 50 stereopure Phosphorodiamidate Morpholino Oligonucleotide (PMO) dinucleotide combinations from early and late eluting prep HPLC chiral purified monomers. - Multiple medicinal chemistry project experience: Hit-to-lead and lead optimization library synthesis for SAR development; Improved potency, physchem and ADME properties as well as resolved PgP issues; and Accelerated go / no go decisions to achieve or exceed milestone timelines.- Carried out syntheses on milligram to kilogram scale (4 – 22 steps).
Dec 2013 - Aug 2018
Senior Principal Researcher- Process Research
- Established and developed a robust synthetic process translatable from lab scale to kilo lab to pilot plant scale for the IND candidate Tazemetostat/E7438.- Carried out tech transfer packages to local (pilot plant) and global CMC partners.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers.- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes.- Authored accurate and detailed experimental procedures and batch records
May 2011 - Dec 2013
Principal Researcher - Process Research
- Assisted in the development, scale up synthesis and tech transfer of the 2nd generation Halaven® C14-26 fragment from D-quinic acid.- Developed robust synthetic processes translatable from lab scale to kilo lab to pilot plant for the IND candidate Cedazuridine/E7727.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers- Developed processes for Crystallization-induced diastereoselective transformation (CIDT) and chemical resolution for stereocontrolled manufacturing- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes- Technical transfer packages to local (pilot plant) and global CMC partners- Collaborated with medicinal chemists via early involvement leading to timely solutions for CMC challenges.- Performed Chemical Hygiene Officer role for process research group for multiple years.- Authored accurate and detailed experimental procedures and batch records
Jul 2007 - May 2011
Senior Research Associate- Process Research
Idenix Pharmaceuticals
- Assisted in the early development of IDX184.- Carried out lab scale experiments which were then translatable to kilo lab scale.
Sep 2006 - Jul 2007
Research Associate- Process Research
Idenix Phamaceuticals
- Developed reproducible industrial scale processes for HCV (NM283 - nucleoside) and HIV (IDX899 - chiral phosphoindole)- Carried out milligram to kilogram scale (4 -14 steps)- Assisted in the management of hazardous chemical waste
May 2002 - Sep 2006
Research Chemist
Pharm-Eco - A Johnson Matthey Company
- Assisted on projects in medicinal and process chemistry meeting all deadlines.- Synthesized, isolated and improved the syntheses of various high quality drug analogs- Carried out gram to milligram scale, multiple step syntheses shipped to client for SAR screening.
Aug 2001 - May 2002
2 education records
Steven Mathieu education
Ms, Chemistry
University Of New Hampshire
Bachelor Of Arts (B.A.), Chemistry
Saint Anselm College
FAQ
Frequently asked questions about Steven Mathieu
Quick answers generated from the profile data available on this page.
What company does Steven Mathieu work for?
Steven Mathieu works for Biogen.
What is Steven Mathieu's role at Biogen?
Steven Mathieu is listed as Senior Scientist - Chemical Process Development at Biogen.
What is Steven Mathieu's email address?
AeroLeads has found 1 work email signal at @biogen.com for Steven Mathieu at Biogen.
Where is Steven Mathieu based?
Steven Mathieu is based in Greater Boston, United States while working with Biogen.
What companies has Steven Mathieu worked for?
Steven Mathieu has worked for Biogen, Eisai Us, Idenix Pharmaceuticals, Idenix Phamaceuticals, and Pharm-Eco - A Johnson Matthey Company.
How can I contact Steven Mathieu?
You can use AeroLeads to view verified contact signals for Steven Mathieu at Biogen, including work email, phone, and LinkedIn data when available.
What schools did Steven Mathieu attend?
Steven Mathieu holds Ms, Chemistry from University Of New Hampshire.
What skills is Steven Mathieu known for?
Steven Mathieu is listed with skills including Chemistry, Organic Synthesis, Process Research, Organic Chemistry, Lc Ms, Chromatography, Nmr, and Mass Spectrometry.
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