Steven Mathieu

Steven Mathieu Email and Phone Number

Self motivated and goal oriented process research chemist with extensive experience in lab scale to plant production @ Biogen
Steven Mathieu's Location
Greater Boston, United States, United States
Steven Mathieu's Contact Details

Steven Mathieu personal email

About Steven Mathieu

Self motivated and goal oriented process research chemist with extensive experience in both lab and plant production in the area of pharmaceutical drug development. Excellent lab skills on both lab and kilo lab scale syntheses. Independent worker with strong technical, observation, analysis, and problem solving skills, presenting clear and accurate results in reports and presentations. Very competent at multi-tasking with good time management skills. Team oriented researcher with strong communication and interpersonal skills. Organic synthesis and process R & D experience in nucleosides / nucleotides / oligonucleotides (PMOs), natural products, macrocycles, and heterocycles.Technical Skills: • Reaxys, Sci-Finder, Excel, Microsoft Word, Power Point, Chemdraw, ISIS Draw, ELN, and D360.• NMR, IR, HPLC, GC, LC/MS, React IR, XRD, KF, H-Cube, Crystal 16, and Lasentech crystallization optimization.• Established robust synthetic processes translatable from lab scale to kilo-lab to plant scale.• Developed and performed recrystallization and trituration processes to isolate high quality intermediates and products.• Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes• Experienced with kilo-lab scale equipment (12 L to 50 L reaction size vessels) and proper lab safety.• Performed reverse-phase and normal-phase chromatography based on TLC results with automated and non-automated biotage systems (4 g to 5 kg silica cartridges).• Supervised pilot plant campaigns to produce GLP tox and GMP quality material.• Transferred technical packages to local (pilot plant) and global CMC partners.

Steven Mathieu's Current Company Details
Biogen

Biogen

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Self motivated and goal oriented process research chemist with extensive experience in lab scale to plant production
Steven Mathieu Work Experience Details
  • Biogen
    Senior Scientist - Chemical Process Development
    Biogen Aug 2022 - Present
    Cambridge, Ma, Us
  • Biogen
    Scientist Ii - Chemical Process Development
    Biogen May 2019 - Aug 2022
    Cambridge, Ma, Us
  • Biogen
    Contract Scientist I - Chemical Process Development
    Biogen Aug 2018 - May 2019
    Cambridge, Ma, Us
  • Eisai Us
    Senior Principal Researcher - Integrated Chemistry Group
    Eisai Us Dec 2013 - Aug 2018
    Nutley, Nj, Us
    - Accelerated high priority Immuno-Oncology project timeline by assisting in early development work on lead compounds, providing API supply for pivotal MTD/DRF & GLP-Tox studies, synthesizing GMP starting material and assisted in tech transfer to global CMC partner to prevent delay in production of clinical API.- Assisted in the early development work for the IND candidate H3B-8800 on both lab and kilo lab scale.- Established robust synthetic processes translatable from lab scale to kilo lab scale on multiple projects.- Contributed to the work in the patent (WO 2017/024264) by synthesizing all 50 stereopure Phosphorodiamidate Morpholino Oligonucleotide (PMO) dinucleotide combinations from early and late eluting prep HPLC chiral purified monomers. - Multiple medicinal chemistry project experience: Hit-to-lead and lead optimization library synthesis for SAR development; Improved potency, physchem and ADME properties as well as resolved PgP issues; and Accelerated go / no go decisions to achieve or exceed milestone timelines.- Carried out syntheses on milligram to kilogram scale (4 – 22 steps).
  • Eisai Us
    Senior Principal Researcher- Process Research
    Eisai Us May 2011 - Dec 2013
    Nutley, Nj, Us
    - Established and developed a robust synthetic process translatable from lab scale to kilo lab to pilot plant scale for the IND candidate Tazemetostat/E7438.- Carried out tech transfer packages to local (pilot plant) and global CMC partners.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers.- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes.- Authored accurate and detailed experimental procedures and batch records
  • Eisai Us
    Principal Researcher - Process Research
    Eisai Us Jul 2007 - May 2011
    Nutley, Nj, Us
    - Assisted in the development, scale up synthesis and tech transfer of the 2nd generation Halaven® C14-26 fragment from D-quinic acid.- Developed robust synthetic processes translatable from lab scale to kilo lab to pilot plant for the IND candidate Cedazuridine/E7727.- API supply (multiple projects) for pivotal MTD/DRF & GLP-Tox, and clinical studies (GMP)- Supervised multiple pilot plant campaigns on industrial scale production of GMP-API- Developed GLP-Tox API quality control strategies: degradation studies, qualification levels for process impurities, degradants, reference standards, and impurity markers- Developed processes for Crystallization-induced diastereoselective transformation (CIDT) and chemical resolution for stereocontrolled manufacturing- Reduced manufacturing cost, time and waste stream by elimination of chromatography with crystallization-based manufacturing processes- Technical transfer packages to local (pilot plant) and global CMC partners- Collaborated with medicinal chemists via early involvement leading to timely solutions for CMC challenges.- Performed Chemical Hygiene Officer role for process research group for multiple years.- Authored accurate and detailed experimental procedures and batch records
  • Idenix Pharmaceuticals
    Senior Research Associate- Process Research
    Idenix Pharmaceuticals Sep 2006 - Jul 2007
    - Assisted in the early development of IDX184.- Carried out lab scale experiments which were then translatable to kilo lab scale.
  • Idenix Phamaceuticals
    Research Associate- Process Research
    Idenix Phamaceuticals May 2002 - Sep 2006
    - Developed reproducible industrial scale processes for HCV (NM283 - nucleoside) and HIV (IDX899 - chiral phosphoindole)- Carried out milligram to kilogram scale (4 -14 steps)- Assisted in the management of hazardous chemical waste
  • Pharm-Eco - A Johnson Matthey Company
    Research Chemist
    Pharm-Eco - A Johnson Matthey Company Aug 2001 - May 2002
    - Assisted on projects in medicinal and process chemistry meeting all deadlines.- Synthesized, isolated and improved the syntheses of various high quality drug analogs- Carried out gram to milligram scale, multiple step syntheses shipped to client for SAR screening.

Steven Mathieu Skills

Chemistry Organic Synthesis Process Research Organic Chemistry Lc Ms Chromatography Nmr Mass Spectrometry Drug Discovery Hplc Medicinal Chemistry Uv/vis Analytical Chemistry Pharmaceutical Industry Drug Design Lead Change Purification Gmp Good Laboratory Practice Standard Operating Procedure Research And Development Research Liquid Chromatography Mass Spectrometry Microsoft Office Microsoft Excel Microsoft Word Microsoft Powerpoint Electronic Lab Notebooks Scifinder Large Scale Optimization Chemdraw Isis Draw Xrd Ir Spectroscopy D360 Reaxys Recrystallization Karl Fischer Titration Nuclear Magnetic Resonance Pilot Plant Drug Development Technical Transfers Laboratory Safety

Steven Mathieu Education Details

  • University Of New Hampshire
    University Of New Hampshire
    Chemistry
  • Saint Anselm College
    Saint Anselm College
    Chemistry

Frequently Asked Questions about Steven Mathieu

What company does Steven Mathieu work for?

Steven Mathieu works for Biogen

What is Steven Mathieu's role at the current company?

Steven Mathieu's current role is Self motivated and goal oriented process research chemist with extensive experience in lab scale to plant production.

What is Steven Mathieu's email address?

Steven Mathieu's email address is st****@****hoo.com

What schools did Steven Mathieu attend?

Steven Mathieu attended University Of New Hampshire, Saint Anselm College.

What skills is Steven Mathieu known for?

Steven Mathieu has skills like Chemistry, Organic Synthesis, Process Research, Organic Chemistry, Lc Ms, Chromatography, Nmr, Mass Spectrometry, Drug Discovery, Hplc, Medicinal Chemistry, Uv/vis.

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