Steven Gruber Email & Phone Number

San Diego, California, United States

• Manage custom and commercial orders for Illumina flagship BeadArray products ranging from DNA Methylation and genotyping applications for human and agriculture species. Facilitate pre-production, quality assurance, and bioinformatic assessment tasks in an independent and team setting.• Collaborate with cross-functional teams in project management and research and development roles. e.g. biochemistry manufacturing, marketing, customer service, software, and product development.• Design and execute wet lab experiments for proof-of-concept array optimizations. Support troubleshooting and assessing data quality for new potential products.• Prepare technical presentations to internal teams and provide recommendations for future technology adoption.• Analyze large data sets in JMP, Illumina proprietary software, and Microsoft Excel to generate results for internal and external customers.• Release materials and structure bill of materials following life cycle management principles across development, pre-release, and commercial statuses.

San Diego, California, United States

• Launched Methylation Screening Array commercial BeadArray product through Illumina's Product Development Process. Evaluated performance of new EX chemistry on Illumina's DNA Methylation Infinium assay workflow for 1000nm beads. Orchestrated 8 beadpool orders comprising of nearly 400,000 oligo designs selected from collaborators, marketing, sales, clinicians, and academic customers. Assisted technical support with training collateral on FAQ and quality control explanations.• Supported launch of DRAGEN Array Methylation QC tool on Illumina's BaseSpace platform.

San Diego, California, United States

• Launched Infinium EPIC Version 2 Methylation commercial BeadArray. Orchestrated 30 beadpool orders comprised of 1.2 million oligo designs selected from marketing, sales, clinical, and academic customers. Assisted technical support with training collateral on FAQ and probe selection quality control explanations.• Recommended to prepare presentations for a monthly multi-omic technical training series to CEO.

San Diego, California, United States

• Supported territory account managers and field application scientists on use of alternative, 3rd-party, quality control calling and sample detection software.• Executed and orchestrated cross-site experiment, verifying automated bisulfite conversion capabilities and assay reproducibility across different liquid handling platforms. • Released technical support documents: BeadArray format compatibility for 24-sample product; bisulfite-conversion kit equivalence with automation platforms to reduce Infinium Methylation workflow by 1-day.• Shared manufacturing expertise and internal quality control logic for bioinformaticians to build final product files.• Socialized and bolstered internal support, encouraging the scale-up and process optimizations to reduce lead-time for custom Methylation BeadArrays.• Balanced time-management across time-zones with Singapore manufacturing technical operations team. Taught colleagues and unfamiliar quality-representatives on risks and nuances of batch-to-batch performance variability and to communicate discordant assay results.

San Diego, California, United States

• Learned internal systems to project manage custom and commercial orders for Illumina flagship BeadArray products ranging from DNA Methylation and Genotyping applications for human and agriculture species.• Accelerated understanding and expertise in both Infinium Genotyping and DNA Methylation lab workflows. Executed wet lab experiments for proof-of-concept array optimizations.• Executed marketing voice-of-customer experiments to expand sample throughput for DNA methylation assay: bisulfite-conversion kit compatibility and automation enablement.• Introduced myself to cross-functional stakeholders to learn processes in manufacturing, marketing, customer service, software, and product development.• Transitioned from On-Site to Work-From-Home during COVID-19 pandemic. Focus shifted from research and development experiments to project management and data analysis support.• Completed Green Belt 6S certification and project while Work-From-Home. • Presented at Illumina Global R&D meeting on COVID patient clinical outcome prediction using a custom DNA Methylation BeadArray. Managed manufacturing operations and expedited delivery in record time. Recognized acknowledgement on paper as technical troubleshooter on data quality checks.• Launched Mouse methylation commercial BeadArray. Coordinated early-access enablement and orchestrated 3-site sample runs for data robustness quality checks.• Understood fundamentals to evaluate BeadArray assay performance and convey results using JMP, Illumina proprietary software, and Microsoft Excel for internal and external customers.

Madison, Wisconsin Area

• Manufacture proteins at small to large-scale from cellular lysis to final bulk enzyme.• User confidence with the following purification systems: LPLC equipment; GE Unicorn software; Tangential Flow Filtration systems; Homogenizer systems for cellular lysis; GE XK-50 to BPG450 Columns.• Hands-on experience with GE Sepharose, ceramic, and gel-based resins including column packing, qualifying, and troubleshooting.• Embarked on assay redevelopment project to improve robustness, efficiency, and precision of commonly run contamination assays. Project involved communicating and influencing Change Control Board members with presentations and data analysis. Project also involved a redesign and revalidation of a 6-tab Excel spreadsheet following ISO:13485 and corporate validation regulations.• Member of a cross-departmental team focused on re-implementing KanBan (visual management) program for sustaining manufacturing material stocks. Executed A3 "nine-box" problem solving framework (Operational Excellence tool) to identify root causes, attack problems, close gaps, and ensure successful confirmed state of program. • Champion 6S in laboratory as 6S Area Leader. Strong focus on moving equipment and process flows into new laboratory spaces.

Madison, Wisconsin, United States

• Learned processes to manufacture proteins at small to large-scale from cellular lysis to final purified bulk enzyme.• Gained confidence with the following purification systems and equipment: LPLC equipment and GE Unicorn software; Tangential Flow Filtration systems; Homogenizer systems for cellular lysis; GE XK-50 to BPG450 columns.• Champion 6S in laboratory as 6S Area Leader. Strong focus on moving equipment and process flows into new laboratory spaces.

Madison, Wisconsin

• Expanding from 2015 internship experience, I prepared dose formulations for pharmaceutical research complying to FDA regulations and client contracts. • Received accelerated training and advanced techniques to safely handle various test article compounds. • Polished strict attention to detail (GLP and GMP) and clear communication skills with peers, principal investigators, and clients.• Created internal job aides and provided guidance to teammates on client specific methods.

Jean-Michel Ane Laboratory, Uw-Madison

• Investigated Rhizobium sp. strain IRBG74 in root nodulation and nitrogen fixation in legume crops.• Applied coursework to a lab setting including: Cloning reactions, PCR, gel electrophoresis, antibiotic selection, pipetting, preparing media, pouring plates, autoclaving, and executing aseptic techniques.• Developed teamwork skills by understanding lab tasks with accurate scientific communication. Independently followed procedures precisely and asked appropriate questions when necessary to solve a problem.• See attachment for Senior poster on experiments focused on genetic refactoring of genes involved in nodulation.

Madison, Wisconsin

• Prepared dose formulations for pharmaceutical research complying to FDA regulations and client contracts. Introduction to GLP and GMP industry standards. • Intern project focused on generating and implementing an archival procedure for non-study specific documents dating from 2010-2014.• Developed leadership and teamwork skills by organizing a philanthropic project with summer interns.

Arlington, Wisconsin

• Organized, sprayed, and evaluated herbicide treatments to numerous field plots with different plant crops and weeds. • Recorded biomass, gas samples, and weed data for graduate conducted research. • Active participant of education programs including: Weeds Science Contest, Extension Days, and Farm Tech Days.