Ming-Tzo (Steven) Wei Email and Phone Number
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• Ph.D. with 10+ years of holistic academic & industry experience in Research and Process/Analytics Development with current focus on allogeneic and autologous CAR-T Cell Therapies, Gene-Editing, and Cell Engineering supporting critical need early phase patient therapies. • Dedicated Team Leader for Gene-Editing Process/ Analytical (cell-based assays) Development and Lifecycle and Process Improvement with CMC development teams for IND and BLA enabling platforms.- Cell and Gene Engineering • Experienced in cell culture (traditional and closed system automation), cell line development (CHO, HEK293, NIH3T3, U2SO), lentivirus engineering, lentivirus transduction, viral/ nonviral gene editing, electroporation, flow cytometry, cell sorting, IF, PCR, and cloning • Investigated mRNA transcription dynamics through spatially resolved genomic approaches (Cas9/ FISH/ MS2) - Cell-based Assay, Large Molecule Characterization, and Programming • Execution of Incucyte and 16+ color BD FACSymphony A5 flow cytometry • Created custom-build FCS, confocal, and 2P microscopies for bioimaging • Studied protein interactions using DLS, spectroscopy, SPR, microscopy, optical tweezers, and electrophoresis • Analyses and automatic measurements via FlowJo, FCS, MATLAB, ImageJ, JMP, and LabView My background in cell engineering and biophysics includes 1) cell and genomic engineering in cell therapies; 2) biophysics in protein interaction; 3) synthetic proteins in transcriptomics; 4) the lipid-nanoparticle (LNP)/ colloidal interactions in the optical and electrical field; 5) biomaterials in regenerative medicine.
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Associate Principal Scientist, Cell Therapy Process DevelopmentCabaletta Bio Jul 2024 - PresentPhiladelphia, Pennsylvania, Us -
Manager Ii, Sr Scientist, Cell Therapy Process DevelopmentBristol Myers Squibb Nov 2022 - Jun 2024Lawrence Township, Nj, Us• Process and analytics development team lead for gene-editing on Allogeneic platform • Responsible for site-to-site technology transfer of gene-editing process and cell-base assay platform (BD A5 flow cytometry, Bioprofile, Cytation5, and Incucyte) for in-process analysis• Led gene-editing team with NGS team to evaluate knockout off-target risk • Led cross-pipeline development initiatives to investigate activation reagent candidates on non-gene-editing and Allogeneic platforms • Led innovation of scale-up bioreactor systems with process analytical techniques for Allogeneic platforms• Led the scale down model process improvements with CMC development teams and authored technique reports to support IND submission through optimization, process improvement and qualification • Supporting manufacturing troubleshooting to provide scientific justification of process deviations • Execute investigations identifying raw material second sourcing (liquid cytokines and activators) • Managed direct team of interns and associates, instructed on scientific understanding, and led hands on process training, provided career mentorship -
Manager I, Sr Engineer, Cell Therapy Process DevelopmentBristol Myers Squibb Sep 2020 - Oct 2022Lawrence Township, Nj, Us• Led the process development and improvement tech team with CMC development teams to support post-IND early phase program development• Responsible for drafting/reviewing regulatory of IMPD IR responses• Supervised and trained junior scientists in laboratory skills and complex study proposals• Developed new cell-selection technique for automation platform• Led process improvement for non-gene-editing platform both on full-scale and SDM • Investigated LVV characterization and virus vector transduction efficiency to support FDA BLA -
Associate Research Scholar/ Postdoctoral Fellow In Chemical And Biological EngineeringPrinceton University Sep 2014 - Aug 2020Princeton, Nj, Us• Developed cell lines to synthesize cellular transcription factor proteins• Investigated transcription kinetics and RNA genetics via optogenetic transcription factors • Investigated rRNA processing function and the large molecule (intrinsically disordered protein/IDP) interactions via designing amino acid mutations and using innovative optogenetic/ microscopy tools -
Research Assistant In BioengineeringLehigh University Jan 2010 - Aug 2014Bethlehem, Pa, Us• Investigated the mechanobiology of ECM-intergin-actomyosin on head-and-neck cancer and dental-pulp stem cells in 2D/3D microenvironment • Studied lipid-nanoparticles (LNP) and light-matter interaction of dielectric colloids and colloidal electrokinetics (dielectrophesis and electrophesis) via a novel opto-force sensor -
Visiting Research Scientist In PhysicsLehigh University Sep 2008 - Dec 2009Bethlehem, Pa, Us• Implemented a point-of-care diagnostics with 1000X sensitivity for virus (engineered lentivirius )• Created a novel real-time SPR sensor to sensing monocytic leukemia cells secretions -
Research Assistant In BiophotonicsNational Yang Ming University Sep 2007 - Aug 2008Taipei, Taipei, Tw• Studied immune responses of LPS-TLR4/CD14 and ROS on macrophage• Designed novel optics-platforms to probe RecA-DNA kinetics and to stretch cells
Ming-Tzo (Steven) Wei Skills
Ming-Tzo (Steven) Wei Education Details
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Lehigh UniversityBioengineering -
National Yang Ming UniversityBiophotonics -
National Dong Hwa University (Ndhu)Physics
Frequently Asked Questions about Ming-Tzo (Steven) Wei
What company does Ming-Tzo (Steven) Wei work for?
Ming-Tzo (Steven) Wei works for Cabaletta Bio
What is Ming-Tzo (Steven) Wei's role at the current company?
Ming-Tzo (Steven) Wei's current role is Associate Principal Scientist, Cell Therapy Process Development.
What is Ming-Tzo (Steven) Wei's email address?
Ming-Tzo (Steven) Wei's email address is mi****@****bms.com
What is Ming-Tzo (Steven) Wei's direct phone number?
Ming-Tzo (Steven) Wei's direct phone number is +160925*****
What schools did Ming-Tzo (Steven) Wei attend?
Ming-Tzo (Steven) Wei attended Lehigh University, National Yang Ming University, National Dong Hwa University (Ndhu).
What skills is Ming-Tzo (Steven) Wei known for?
Ming-Tzo (Steven) Wei has skills like Photonics, Optics, Biophotonics, Biophysics, Bioengineering, Cell, Microscopy, Optical Tweezers, Confocal Microscopy, Rheology, Raman Microscopy, Electrophoresis.
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