Steven Twiddle Phd, Frsc Email & Phone Number

Sandwich, England, United Kingdom

Sandwich, England, United Kingdom

• Director of Process Chemistry in the Chemical Research & Development (CRD) function of Pharmaceutical Sciences.Primary responsibilities include:
• Portfolio Delivery: Accountable for the delivery of a portfolio of API programs covering a range of therapeutics areas.
• CRD Sandwich Labs Management Team: Determined operational activities to ensure safe & effective running of a multi-skilled laboratory group of 60-70 colleagues to guarantee departmental deliverables.
• Team Lead: Proactively supported the scientific & personal development of all direct reports through regular discussions, mentoring and performance feedback.
• Resource Lead: Forecasted short and long-term project resource estimations and led direct allocation of laboratory resource across the portfolio.
• Capital Lead: Coordinated, allocated and tracked multiple budgets to deliver CRD laboratory and plant capital equipment needs.

Sandwich, England, United Kingdom

• Associate Research Fellow in the Chemical Research and Development (CRD) function of Pharmaceutical Sciences.Demonstrated skills and experience:
• Applied extensive knowledge and experience to define the strategic direction of API programs and lead matrix teams to ensure program deliverables.
• Provided strategic and technical guidance to process chemistry laboratory teams to deliver commercially viable synthetic routes.
• Implemented contemporary methodologies of data driven process design and QbD to deliver robust and efficient chemical processes capable of API delivery at commercial scale and of commercial quality.
• Utilised experience gained through multiple tech transfers, to both internal and external GMP manufacturing facilities, to coordinate the delivery metric tonne quantities of API.
• Tracked sustainability metrics and API cost to rationalise their evolution over a projects lifecycle to demonstrate the return on investment of development activities.

Sandwich, Kent, UK

• Senior Principle Scientist in the Chemical Research and Development (CRD) function of Pharmaceutical Sciences.Demonstrated skills and experiences:API Project Lead and Unit of Work Lead: Technical responsibility for the.
• Provide technical guidance, including co-development of processes, to external vendors to ensure delivery of appropriate quality API starting materials.
• Conceive and critique proposed commercial routes to drug candidates, intermediates or starting materials based on scientific rationale, technical challenges and specific business needs.
• Significant implementation of Process Analytical Technology (PAT) and science of scale tools to drive process development.
• Focus on API quality through impurity tracking, including Genotoxic Impurities, resulting in the development of an appropriate control strategy.
• Collaboration at the API to Drug Product/Formulation interface to ensure manufacture of API with appropriate physical properties.

Sandwich, Kent, UK.

Principle Scientist in the Chemical Research and Development (CRD) function of Pharmaceutical Sciences.

Ringaskiddy, Co. Cork, Ireland.

Responsible for facilitating the technical transfer of an API synthesis from R&D to manufacturing ensuring the process was executed as designed in order to meet all validation requirements.

Sandwich, Kent, UK.

Senior Scientist in the chemical research and development (CRD) function of Pharmaceutical Sciences.

Tallahassee, FL, USA.

Received an MDS fellowship to undertake a synthetic organic chemistry postdoctoral research position under the mentorship of Prof. M. E. Krafft.

Phd, Synthetic Organic Chemistry

Studied for an EPSRC and GSK CASE sponsored PhD entitled 'The Stereoselective Synthesis of Polyene Natural Products'.

Msci, Chemistry

Obtained 1st Class Honours.