Stuart Andrew Morgan Email & Phone Number

Birmingham, England, United Kingdom

Birmingham, Uk, And Toronto, Ca

Currently, there is an urgent need to understand the pathogenesis underpinning major metabolic diseases, such as type 2 diabetes, due to their dramatically increasing prevalence. My research focusses on identifying new genes controlling key metabolic pathways in response to important hormonal cues, such as insulin and glucocorticoids, with the ultimate goal of uncovering new therapeutic targets for the treatment of major metabolic diseases. Specifically, I am interested in delineating the regulatory features of how insulin controls glucose uptake [GLUT4 trafficking] into skeletal muscle, and how glucocorticoids control gene expression in the liver. My approach harnesses whole-genome CRISPR-cas9 based technologies, which have transformed many areas of biological research since the discovery that the bacterial immune system could be re-engineered for gene editing in mammalian cells. Using both myocyte and hepatocyte cell-based models, I am employing this powerful genetic tool to simultaneously screen thousands of genes (on a genome-wide scale) for involvement in these metabolic pathways. In summary, my whole-genome CRISPR-cas9 based screening approach to studying metabolism has the potential to significantly advance our understanding of key pathways driving the development of major metabolic disease.

Canada

I made the ground-breaking discovery that pre-receptor glucocorticoid metabolism by the enzyme 11b-HSD1 drives the metabolic side-effects associated with circulatory glucocorticoid excess in Cushing’s syndrome.

Ohio, United States

Phd Molecular Endocrinology (Case-Award), Endocrinology, Insulin Action, Skeletal Muscle, Lipid Metabolism

Demonstrated that glucocorticoids induce insulin resistance in skeletal muscle through dysregulated lipid metabolism. Also highlighted.

Bsc Biochemistry, Biochemistry, 1St Class

Education record