Stuart Endo-Streeter Email & Phone Number

Chapel Hill, NC, US

Chapel Hill, NC, US

I am continuing my work using cryoEM to investigate PLCg1 signaling, and investigating oncogenic mutations in PLCb4. In parallel I am investigating the structure of PLCg1 bound to various inhibitors using protein x-ray crystallography and exploring the mechanisms of inhibition. My work continues to include all my previous responsibilities in the lab, as.

Chapel Hill, NC, US

I used cryoEM to investigate the mechanism of PLCg1 activation and regulation. I also began investigating the role of PLCb4 as a driver of multiple cancers, through metabolic and enzymatic assays. My responsibilities included lab operations and infrastructure, including configuration, training, and maintenance of our FPLCs, Emulsiflex, tissue culture room.

Chapel Hill, NC, US

I founded and ran the Structural Biology Discussion Group (SBDG) seminar series which ran monthly from 2017 through 2020, when it was absorbed into the Macromolecular X-ray crystallography core. I founded the SBDG to address the need at UNC for a protein crystallography seminar series - the NMR and Mass Spectrometry cores have similar series, but at the.

Chapel Hill, NC, US

In January of 2018 I was asked to temporarily take responsibility for the UNC Macromolecular X-Ray Crystallography Core after the departure of the previous director. What was expected to be a two-three month role that maintained the minimum services of the core turned into a full six months coordinating and operating the core during the prolonged candidate.

Chapel Hill, NC, US

I led our high-throughput screening project to identify inhibitors of oncogenic Galpha protein Q in a collaboration with AstraZeneca and the UNC Center for Integrative Chemical Biology and Drug Discovery. With the CICBDD, I translated the assay to the HTS stage and in collaboration with AstraZeneca through the Open Innovations program, screened over 2.

I was the primary owner and head instructor of Tactical Kung-Fu and Mixed Martial arts from 2015-2017. I was responsible for our curriculum, leading classes, recruitment, and management, working jointly with my business partner and fellow instructor, who now leads the school. I retired from the business when I was promoted at UNC and moved.

Durham, North Carolina, US

As the structural biologist of a computer science lab, I brought a new background and perspective to the protein design work being carried out, and the ability to test those designs in real life. I extensively used yeast and bacterial expression systems during the design and testing of an inositol phosphate sensor system. I was also significantly involved.

Waltham, MA, US

While a technician at Brandies University in the Department of Biochemistry I was responsible for my own structural biology project, training our undergrads in fundamental biological, biochemistry, and genetic techniques, and managed the lab infrastructure. My responsibilities included keeping our old FPLC running, coaxing along the ancient table-top.

Doctor Of Philosophy - Phd, Biochemistry

Bachelor Of Science - Bs, Biochemistry And Biophysics

Bachelor Of Science - Bs, Microbiology