Sudipta Lahiri, Ph.D. Email & Phone Number

New York, Ny, Us

New York, Ny, Us

New York, New York, Us

Objective: Investigating Mechanism of Sensitivity and Resistance in Response to PARP Inhibitor Treatment in BRCA2 Mutated Breast and Ovarian Cancers• Developed and implemented standard operating procedures for HTS and imaging spatiotemporal kinetics of HR proteins at replication forks post PARPi treatment• Purified and developed 10+ analytical assays to elucidate the mechanism of action for DNA repair proteins like BRCA1, BRCA2, RAD51, PARP1, and POLθ along with cellular assays targeting inhibitors like PARPi, CDK2i, and POLθi.• Optimized and developed 5+ bio-functional assays and facilitated new target identification goals and documented experimental data, managing laboratory notebook, and spreadsheets to present data as evidenced by 10+ presentations.• Experience as a dedicated project manager who contributes to cross-departmental teams and team’s go-to person in the lab for advice, helps in troubleshooting experiments and with interpretation when needed, as evidenced by amicably working with pharma collaborations and mentoring, training, and managing 5 junior level scientists in their research projects.

New Haven, Ct, Us

Objective: Elucidation of Stalled Replication Forks Processing in Response to PARP Inhibitor Treatment in BRCA2 Mutated Breast and Ovarian Cancers• Developed and optimized 5+ standard operating procedures to express, isolate and purify human BRCA1, PALB2, PARP1, RAD51, and MRE11 E.coli, insect (SF9/21), and mammalian (HEK293T) cells.• Interacted and collaborated with pharmaceutical companies to facilitate program progression and facilitated new target identification goals and documented experimental data, managing laboratory notebooks, and spreadsheets to present data as evidenced by 5+ presentations and 2 collaborations.• Mentored and trained 4+ graduate students in designing research projects and guided their daily work• Planned and managed 4 independent research projects with good publication records as evidenced by 2 peer-reviewed publications and 4 collaborative grants.• Developed biochemical and cellular assays that explain the mechanistic insights into how BRCA2 proficient cells tolerate PARPi treatment and why the loss of BRCA2 sensitizes cells to PARPi. This work is now ready for submission.

Strong communication and presentation skills to simplify complex concepts and convey them convincingly across large audiences as seen by more than 10+ years of teaching experience in lecture and laboratory courses such as Biochemistry, Organic Chemistry, Biology, Physical & General Chemistry with a 100% completion rate.• Organized and graded weekly problem sets and exams and provided constructive feedback. • Scheduled and planned office hours and assisted students with weekly and weekend help sessions.

Middletown, Ct, Us

Objective: Investigated the role of DNA repair proteins like MutS (Msh2-Msh6, Msh2-Msh3 and Msh4-Msh5) on DNA structure and recombinational repair. • Recognition as the first to purify and biochemically characterize DNA repair protein scMutSγ • Planned and managed 3 independent research projects with excellent publication records as evidenced by 4 peer-reviewed publications and 2 grants.• Developed and implemented 15 standard operating procedures related to research projects, lab equipment maintenance and operation. • Prepared, coordinated, and tutored 5 advanced courses, such as Physical Chemistry for Life Sciences, Structural Biology Lab, Practical Methods in Biochemistry, Genetics and Genomics.• Mentored, trained and managed 10 undergraduate and 4 graduate students in their research projects and daily work.

Queens, Ny, Us

Objective: Synthesized peptide biosensors to understand enzyme functions. • Synthesized, purified, and characterized more than 10 kinase biosensors using solid-phase peptide chemistry and LC-MS methods. • Developed and implemented 5 standard operating procedures for biosensor synthesis, production, protein purification, and fluorimetric assays. • Supervised and managed 5 undergraduate students in the research lab and mentored their daily work.• Independently taught organic chemistry laboratory courses. Organized weekly problem sets and exams, and graded students’ materials from lecture and lab courses.

Kolkata, West Bengal, In

Objective: Point prevalence study on high-risk individuals with Hepatitis B and C infection. • Collected blood samples from patients and performed ELISA to account for infections• Maintained and filed clinical records for more than 200 patients; worked alongside the physician and met with patients to discuss hepatitis infection awareness and results from the ELISA assay.

Doctor Of Philosophy (Phd), Biochemistry, Biophysics And Molecular Biology

Master’S Degree, Biomedical Sciences

Master’S Degree, Biotechnology

Bachelor’S Degree, Chemistry, Microbiology And Zoology