Sue Foxall Email & Phone Number

• Develop, optimize and validate cellular assays for screening small molecules during Hit ID and Lead Optimisation, covering multiple disease areas including Inflammation, Oncology, Senescence, and Neurodegeneration.
• Successfully validated targets through development of in-house disease-relevant assays and external collaborations using the Benevolent platform TM.
• Highly proficient using automation of assays.
• Responsible for translational and target engagement assays including… Show more
• Responsible for translational and target engagement assays including biomarkers for preclinical and clinical applications.
• Managing and overseeing outsourced projects including assay transfer, assay set up, and validation

• Identification of novel targets for the treatment of senescence-related pathologies.
• Development and implementation of cell-based assay for small molecule screening to support multiple programs at various stages of the drug discovery pipeline.
• Cell imaging, IF staining and analysis for measurement of disease severity and compound effect.
• Target engagement studies, western blot expression and MSD biomarker analysis.
• Assay ability assessments of upcoming programs and… Show more
• Assay ability assessments of upcoming programs and assessment of target suitability for hit to lead progression. Show less

• Enzyme based target for the treatment of inflammatory diseases.
• Cellular enzyme assays in multiple species for small molecule screening supporting hit to lead and lead optimisation.
• Development and optimisation of radioligand assay for compound screening.
• Radiation Protection supervisor ensuring compliance with regulations and completion of documentation, reports, and annual inspections for the use of radioisotopes.

• Functional calcium signalling and fluorescence-based assays, design and implementation.
• Cell culture support and maintenance of cell lines for multiple programmes.
• Enzyme inhibition studies in multiple species and tissues.
• Development of assay for inflammatory markers in ex-vivo tissues.

Cambridge, United Kingdom

• Development of cell-based assays to screen novel compounds for anti-obesity projects.
• Automation of screening procedures.
• Cell line transfection and clone selection.

• Anti-obesity screen using radiolabelled tracer cell-based assay.
• Differentiation of cell lines for formation of adipocyte cells.

Cambridge UK

• Production of genetically modified wheat and barley plants using microspore plant cell culture.
• Double haploid generation and vector comparison to support breeding programme.
• Management of 3 permanent staff and training and mentoring of summer students.

Cambridge, United Kingdom

• Characterisation of cellular and biochemical structure of potato breeding lines and development of a predictive model for the performance of different varieties in the manufacturing process.
• Glucosinolate analysis of oil seed rape to support the breeding programme.

Master Of Philosophy (Mphil)

Bachelor Of Applied Science (Basc), Applied Biology, 2I