Sebastiaan Vanuytven Email and Phone Number
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With a strong background in computational biology and biomedical research, I am a motivated postdoctoral researcher specializing in deciphering cellular heterogeneity in cancer. At the Laboratory of Stem Cells and Cancer at ULB, my research focuses on utilizing single-cell and spatial (multi-)omics to deepen our understanding of therapy resistance and metastasis in cancer. This work is crucial for developing more effective cancer treatments.During my time as a computational PhD fellow at the Laboratory of Reproductive Genomics at KU Leuven and the Cancer Genomics Laboratory at the Crick Institute, I developed a solid foundation in genomic research and bioinformatics. Collaboration is at the heart of my approach, and I have had the privilege of working with esteemed colleagues and institutions on groundbreaking projects. My goal is to continue contributing to the field of cancer biology by addressing key challenges through innovative research and collaboration.Outside the lab, I find joy and balance in activities like running, rowing, bouldering, and playing chess. These pursuits not only enrich my personal life but also enhance my creativity, strategic thinking, and problem-solving skills.I am eager to leverage my expertise, passion for research, and collaborative spirit to engage in pioneering projects that push the boundaries of our understanding of cancer biology.
Université Libre De Bruxelles
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Postdoctoral ResearcherUniversité Libre De Bruxelles Jan 2023 - PresentBrussels Metropolitan AreaMy postdoctoral research aims to investigate the role of cell-cell communication within the tumour microenvironment of squamous cell carcinoma, focusing on tumour growth, epithelial-to-mesenchymal transition (EMT), metastasis, and therapy response. -
Phd StudentKu Leuven Jul 2017 - Dec 2022LeuvenDuring my PhD, I focused on exploring the role of tumor heterogeneity in epithelial-to-mesenchymal transition (EMT) and therapy resistance using single-cell (multi-)omic techniques. I helped develop a novel single-cell genome-and-transcriptome sequencing method (Gtag&T) that doesn't require whole-genome amplification, making it more efficient and cost-effective than traditional methods. We applied this method to melanoma patient-derived xenograft (PDX) models, uncovering the influence of subclonal copy-number aberrations (CNAs) on cell state plasticity during treatment. This work also led to the first phylogenetic reconstruction of a primary tumor annotated with transcriptomic cell states, revealing new insights into gene dosage effects and drug resistance.Additionally, I contributed to benchmarking CNA inference methodologies from scRNA-seq data, finding that current approaches lack accuracy, underscoring the need for multi-omic strategies. I also investigated NP137, a new anti-cancer treatment, demonstrating its potential to reduce lung metastasis and enhance chemotherapy response in skin squamous cell carcinoma models.Beyond my main research projects, I participated in single-cell and spatial (multi-)omics projects addressing prostate heterogeneity, muscular dystrophy, bone biology, embryology, and Alzheimer’s disease.PhD dissertation: "Single-cell multi-omics sequencing to understand the nature, extent and biology of cellular heterogeneity in cancer"Supervisors:Prof. Thierry VoetProf. Peter Van LooProf. Giuseppe Floris -
Master Thesis BioinformaticsCenter For Human Genetics Leuven Aug 2016 - Jun 2017Center For Human Genetics"Single-cell sequencing to understand the biology of cellular heterogeneity in cancer"Promotor: Prof. Thierry VoetCo-promotor: Prof. Stein AertsSupervisors: Dr. Daniel Brown & Dr. Alejandro Sifrim
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Master Thesis Biomedical SciencesMaster Thesis Student At The Laboratory Of Molecular Virology And Gene Therapy Aug 2014 - Jun 2015Laboratory Of Molecular Virology And Gene Therapy"Development of safer MLV-based gene therapy vectors: studying BET protein-chromatin occupation and generation of p12-fusions"Promotor: Zeger Debyser, MD PhD.Co-Promotor: Rik Gijsbers, PhD.Supervisor: Jonas Demeulemeester, PhD.
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InternshipKu Leuven Apr 2014 - May 2014Laboratory Of Virology And Experimental Chemotherapy“Design and validation of a pET-31b C34-expression system in OmniMAX competent E. coli”Supervisor: Ben Verpaalen
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InternshipKu Leuven Mar 2014 - Apr 2014Laboratory Of Computational Biology“Analysis of fusion transcripts, SNVs and INDELs in melanoma"Supervisor: Zeynep Kalender Atak
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InternshipKu Leuven Feb 2014 - Mar 2014Laboratory Of Molecular Virology And Gene Therapy“Validation of PC2 knockdown in HeLaP4 and SupT1 cells, and the effect on early-stage HIV replication” Supervisor: Caroline Weydert
Frequently Asked Questions about Sebastiaan Vanuytven
What company does Sebastiaan Vanuytven work for?
Sebastiaan Vanuytven works for Université Libre De Bruxelles
What is Sebastiaan Vanuytven's role at the current company?
Sebastiaan Vanuytven's current role is Postdoctoral Researcher in Bioinformatics | Expert in Single-Cell and Spatial Omics Analysis in Cancer Research | Bridging Biomedical Research and Computational Biology.
What is Sebastiaan Vanuytven's email address?
Sebastiaan Vanuytven's email address is sebastiaan.vanuytven@ulb.be
What schools did Sebastiaan Vanuytven attend?
Sebastiaan Vanuytven attended Ku Leuven, Ku Leuven, Ku Leuven, Vrije Sint-Lambertusscholen Westerlo.
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