Immune-Oncology

Immune-Oncology

Investigated tumor-associated Foxp3+ regulatory T cells and the impact of autoimmune regulator (AIRE) expression on the Foxp3+ regulatory T cell repertoire.• Designed and performed experiments that led to a high impact first author publication in Science• Co-authored 3 Reviews published in scientific journals• Received a prestigious research grant from the German Research Foundation• Participated in 2 successfully accomplished NIH grant application processes• Introduced and… Show more Investigated tumor-associated Foxp3+ regulatory T cells and the impact of autoimmune regulator (AIRE) expression on the Foxp3+ regulatory T cell repertoire.• Designed and performed experiments that led to a high impact first author publication in Science• Co-authored 3 Reviews published in scientific journals• Received a prestigious research grant from the German Research Foundation• Participated in 2 successfully accomplished NIH grant application processes• Introduced and led weekly immunology journal club meetings• Trained and led graduate students and rotational students Show less

Investigated the role of IL-6 cytokine signaling in a murine autoimmune hepatitis model.• Developed and conducted experiments that led to a first author publication and 2 co-authorships in peer reviewed scientific journals• Co-authored 1 Review in the Journal of Autoimmunity• Trained M.D. internship students in basic biochemical assay methods• Tested the therapeutic potential of the designer molecule sgp130Fc in liver inflammation• Attended strategic research meetings for… Show more Investigated the role of IL-6 cytokine signaling in a murine autoimmune hepatitis model.• Developed and conducted experiments that led to a first author publication and 2 co-authorships in peer reviewed scientific journals• Co-authored 1 Review in the Journal of Autoimmunity• Trained M.D. internship students in basic biochemical assay methods• Tested the therapeutic potential of the designer molecule sgp130Fc in liver inflammation• Attended strategic research meetings for the founding and application process of the Collaborative Research Center 841 - “liver inflammation” Show less

Implemented an in vitro erythropoiesis assay to identify critical transcription factors for human red blood cell development• Identified a transcription factor subunit switch as key step in red blood cell maturation in vitro• Established real-time R.T. PCR as a tool for future quantification of cytokine receptor expression

Performed and optimized protein expression of the HAV 3C protease with selectively labeled amino acids for NMR analysis.• Initiated a team with other undergraduate students to increase efficiency and combine resources for protein purification processes.