Swati Kumar Email & Phone Number

Cambridge, England, United Kingdom

Develop a restriction enzyme-based approach for in vivo targeting of mtDNA mutations specifically present in tumours in in vivo mouse models• Design mitochondrially targeted RE (mitoRE, mitoTALINS) and test their specificity and efficacy in depletinghomoplasmic mutated mitochondrial copy number in breast cancer cell• Assess the effect of restriction enzyme induced mtDNA depletion on tumour growth, tumour cell death andsensitivity to chemotherapeutics.• Develop a novel tumour therapy and an experimental model that will allow controlled mtDNA depletion in anypatient-derived mouse tumour model.

Coventry, United Kingdom

Project title: Developing and validation of an in-vitro clock controlled blood-brain barrier model for chronopharmacology- Determining the circadian regulation of the mRNA, protein expression and activity of the efflux transporter (ABCB1) in an in-vitro BBB model- Study the rhythmic expression in ABCB1 in mice and validate the in-vitro findings.- Demonstrate the relevance of such clock control for the disposition of anticancer drugs in this chronoBBB model.

Preston, United Kingdom

- Delivering lectures and tutorial sessions to 2nd and 3rd biomedical science course- Designing research projects and experiments for lab based modules- Marking coursework, providing feedback & covering learning outcomes of the modules

Preston, United Kingdom

Project title: Commercial use of a three dimensional, physiologically relevant in-vitro human blood brain barrier model for screening novel drugs and drug delivery systems- Establishing 3D culturing systems to improving prediction of glioma therapeutics- Setting up various screening assays on the tri-culture BBB model for potential collaborators- Responsible for designing experiments, data analysis & compiling them as quarterly progress reports

Preston, United Kingdom

Supervising large groups of undergraduate bioscience and pharmacy studentsProviding assistance in lab practice, experimental design and data analysis skillsAssessing lab performance and interpretation of the experiments by marking lab records for first and second year pharmacy modules.Responsible for keeping a regular check for records of the COSHH, health and risk assessments documents.

Bachelor Of Science (Bsc) Hons, Biomedical Sciences

Doctor Of Philosophy (Phd), Oncology And Cancer Biology

The project was to design an all human, fully characterised and physiologically relevant in vitro blood brain barrier (BBB) model.