Tai-An Lin Email & Phone Number

Stamford, Connecticut, Us

Cambridge, Ma, Us

Cambridge, Ma, Us

Boston, Massachusetts, Us

Immuno-Oncology Translational Innovation Platform - Biomarkers and Tumor MicroenvironmentExperimental Medicine - Clinical Biomarkerso Served as head of immune-oncology (IO) biomarker and translational research group and led pre-clinical IO translation, biomarker, and precision medicine strategy o Developed and executed bedside-to-bench and bench-to-bedside translational research strategy for guiding IO new target identification, drug discovery and clinical developmento Led teams and executed studies to understand mechanism of action, established target engagement/pharmacodynamic biomarkers, and explored combination of IO therapeuticso Formulated patient stratification and selection hypothesis and generate predictive biomarker strategyo Collaborated closely with bioinformatic colleagues to analyze high dimensional pre-clinical and clinical trial data for identifying predictive and PD biomarkerso Established academic collaborations for understanding tumor microenvironment (TME) immune profile for identifying predictive biomarkers and support European public-private TME immune profiling consortiumo Worked closely with internal and external stakeholders to execute IO biomarker and translational research effortso Supervised, mentored, and supported career development of 13 scientists at PhD, MS, and BS levels

Lawrence Township, Nj, Us

Immuno-Oncology Drug DiscoveryTumor MicroenvironmentImmuno-Oncology Small Molecule Biologyo Led multi-disciplinary teams with international members and advanced compounds to clinical trials in the immuno-oncology area for treating cancerso Provided key inputs, direction, and aligned priorities to execute immuno-oncology drug discovery strategyo Executed PD biomarker discovery and explored drug combination efforts to guide developmento Prepared study reports, Investigator Brochure and IND summary for regulatory submissionso Supervised and mentored a biology group including scientists at PhD, MS, and BS levels

Raritan, New Jersey, Us

Disease Integrative Biology, Immunology Therapeutic AreaFocus on innovative solutions for rheumatoid arthritis and inflammatory bowel disease-Analyzed disease signature network to understand disease progression biology and remission/resistance mechanisms of current therapies-Identified and assessed mechanisms and drug targets for deep and sustained response, prevention, and cure-Established co-culture platforms of autologous T cells and antigen presenting cells for generating gene expression signatures of co-stimulatory molecules and for evaluating combination efficacy of bio-therapeutics

Switzerland 🇨🇭 , Ch

Oncology and Immunology/Inflammation Disease Biology Area RNA Therapeutics (03/2008 – 12/2010) Established drug target strategies and led multi-disciplinary drug discovery teams to advance compounds to clinical trials in the areas of Oncology, Immunology, and Inflammation - Initiated new drug discovery programs and led all phases of pre-clinical discovery efforts - Operated global drug discovery teams and collaborated with various groups including medicinal chemistry, in vivo pharmacology, pharmacokinetics, drug metabolism, and non-clinical safety group to provide compound efficacy and safety data for clinical trials - Advanced compounds from initial hits/leads to clinical leads and clinical candidate status - Planned biomarker strategy and discovered potential biomarker for translational development - Prepared patent applications, investigator brochure, and published several biology papers Provided tumor immunology platform and implemented immune mechanism of action studies - Developed in vivo, ex vivo, and in vitro immune assays to evaluate/validate the immune activation status of a cancer therapeutic antibody. Developed siRNA as a new therapeutic modality in the areas of Oncology, Respiratory Inflammation, and Metabolic Diseases. - Applied siRNA/shRNA for target biology and validation studies - Evaluated several siRNA delivery strategies including small molecule-conjugated lipid nanoparticle for targeting cancer cells, leukocytes, and lung epithelial cells Supervised biochemistry and cellular biology laboratories - Line management responsibility for Senior Principal Scientist, Principal Scientist, Associate Principal Scientist, and Senior Scientist - Identified and set up new technologies and equipments to facilitate drug discovery - Designed and conducted cellular and biochemical experiments

Lawrence Township, Nj, Us

Senior Research Investigator II, Oncology and Immunology Drug Discovery (03/2002 – 05/2005)Senior Research Investigator I, Oncology and Immunology Drug Discovery (05/1999 – 02/2002)Research Investigator II, Immunology, Inflammation, and Pulmonary Drug Discovery (04/1996 – 04/1999) Contributed to the early discovery efforts of the marketed drug SPRYCEL (dasatinib) Initiated and led drug discovery programs in the areas of Oncology, Immunology, and Inflammation- Focused on protein kinase projects in Oncology and Immunology- Developed enzymatic and cell-based assays for evaluating compound potency and toxicity- Optimized assays in HTS formats, such as HTRF, SPA, and FLIPR, for lead discovery- Collaborated with lead discovery group and medicinal chemists to identify and optimize leads- Designed animal modeling studies to determine compound efficacy, PK, and toxicity in vivo- Performed gene cloning, expression and protein purification for drug discovery Recruited, supervised, and developed PhD and MS/BS research investigator and research scientists

St. Louis, Mo, Us

 Supervisor: John C. Lawrence, Jr. Studied cellular signal transduction mechanisms linked to insulin and type II diabetes Cloned mouse cDNAs for two novel regulatory proteins of translation initiation induced by insulin Elucidated the function and regulation of novel proteins involved in insulin-induced translation initiation Experienced in adipocyte biology and current technology of molecular biology and biochemistry, such as molecular cloning, recombinant protein production, protein purification, FPLC, ELISA, immunoprecipitation, Northern, Western Blotting and so forth

Phd, Biochemistry

Bs, Food Science