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Expert in AAV Gene Therapy, CRISPR-Cas9 systems and preclinical in vivo study design and execution.Modalis Therapeutics info: https://www.modalistx.com/en/
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Director - In Vivo PharmacologyModalis Therapeutics Oct 2023 - PresentCambridge, Massachusetts, Us -
Associate DirectorModalis Therapeutics Oct 2022 - Oct 2023Cambridge, Massachusetts, Us -
Principal ScientistModalis Therapeutics Oct 2021 - Oct 2022Cambridge, Massachusetts, Us -
Senior ScientistModalis Therapeutics Oct 2019 - Oct 2021Cambridge, Massachusetts, Us -
ScientistModalis Therapeutics Oct 2017 - Oct 2019Cambridge, Massachusetts, Us -
Postdoctoral FellowHarvard Medical School And Massachusetts General Hospital Nov 2009 - Oct 2017Boston, Massachusetts, UsConducted research in the areas of Type 2 Diabetes, Cardiovascular Disease and Diabetic Retinopathy in Dr. Paul Huang's Laboratory - Studies funded by F. Hoffman‐La Roche Pharmaceutical Company• Performed morphometric analysis of pancreatic islet endothelial cells of diabetic mice.• Developed a novel technique for isolation of pancreatic islet endothelial cells and identified differentially expressed genes in diabetic islet vasculature.• Generated knockout mouse models to investigate the effect of multiple genes on glycemic control and diabetic retinopathy in mice. -
Research AssistantMedical College Of Wisconsin Aug 2005 - Oct 2009Wi, UsGraduate Student at Department of Physiology in the laboratory of Frank Park. Focus on Gene Therapy, AAV biology and Kidney Disease.• Studied in vivo transduction efficiency of AAV2, AAV8 and AAV9 in the rat kidney.• Produced and injected AAV gene therapy products to study targeted renal transduction with different AAV serotypes and different route of administrations (intra‐parenchymal, intra‐ureteral and intra‐arterial).• Performed in vitro and in vivo studies to understand the role of 20‐HETE (a paracrine eicosanoid) in protection against renal ischemia/Reperfusion (I/R) injury.• Produced modified lentiviral vectors to genetically manipulate renal cell lines to overexpress 20‐HETE producing enzymes which resulted in increased protection against ischemic insult. • Identified intracellular signaling mechanisms that are activated by 20‐HETE and its analogs. -
Research AssistantLouisiana State University Feb 2004 - Sep 2005Baton Rouge, La, UsPhD Student in the Louisiana State University Health Sciences Center, Department of Pharmacology and Experimental Therapeutics department. - Study focus on DNAS1L3 gene. -
Undergraduate ResearcherUniversity Of Connecticut Aug 2003 - Dec 2003Storrs, Ct, UsUndergraduate work in the Laboratory of Charles Giardina - Performed research on COX-2 protein.
Talha Akbulut Skills
Talha Akbulut Education Details
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Medical College Of WisconsinPhysiology -
University Of ConnecticutMolecular And Cell Biology
Frequently Asked Questions about Talha Akbulut
What company does Talha Akbulut work for?
Talha Akbulut works for Modalis Therapeutics
What is Talha Akbulut's role at the current company?
Talha Akbulut's current role is Director at Modalis Therapeutics.
What is Talha Akbulut's email address?
Talha Akbulut's email address is ta****@****ail.com
What is Talha Akbulut's direct phone number?
Talha Akbulut's direct phone number is +141453*****
What schools did Talha Akbulut attend?
Talha Akbulut attended Medical College Of Wisconsin, University Of Connecticut.
What skills is Talha Akbulut known for?
Talha Akbulut has skills like Pharmacology, Physiology, Cell Biology, Animal Models, Molecular Biology, Cell Culture, Microscopy, In Vivo, Immunohistochemistry, Western Blotting, Fluorescence Microscopy, Type 2 Diabetes.
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