Thomas Chamberlain Email & Phone Number

Vancouver, Bc, Ca

Vancouver, British Columbia, Canada

Vancouver, British Columbia, Canada

• Postdoctoral training researching inflammatory signaling pathways in macrophages with a focus on the negative regulatory cytokine interleukin-10 (IL10) and the inositol phosphatase, SHIP1.• Performed CL3 studies looking at macrophage inflammatory responses to SARS-CoV-2 infection and relevance to hyper-inflammation in COVID-19 pathogenesis.• Performed in vitro cell-based, and in vivo models of inflammatory disease with a focus on the development of small molecule activators of SHIP1 to alleviate inflammation by mimicking IL10 anti-inflammatory actions. • Conducted biochemical, molecular, and immunological procedures to gain insight into signal transduction pathways including extensive cell culture, flow cytometry, confocal microscopy, immunoblotting, ELISA, real-time PCR• Leadership role in multiple lab projects and collaborations• Prepared standard operating procedures, written reports and preparation of research manuscripts

Northern Institute For Cancer Research

Project title - “Prognostic, predictive and pharmacodynamic value of circulating tumour cells in oesophagogastric cancer patients in receipt of palliative systemic therapy”Development and optimisation of fluorescent biomarkers to- detect and characterise circulating tumour cells (CTCs) in gastric cancer patients- predict response to chemotherapy agents - study pharmacodynamic response of chemotherapy treatment • Co-ordination and collection of patient blood samples from local cancer centres • Analysis of gastric cancer cell lines and patient samples using ImageStreamX Mark II high resolution microscopy/flow cytometry.• In vitro studies using various gastric cancer cell lines to support biomarker development and optimisation

Northern Institute For Cancer Research

• Worked as part of the Pharmacology research group in relation to Paediatric clinical studies• Undertook research into the pharmacology and pharmacokinetics of chemotherapeutic drugs• Quantification of drugs in patient samples by chromatographic techniques including HPLC and LC/MS• Pharmacogenetic analysis of clinical samples by TaqMan genotyping assays• Organisation of clinical sample receipt and storage• Data compilation and co-ordination with research centres across the UK• Method development for quantification of chemotherapeutic drugs in clinical samples

Doctor Of Philosophy (Ph.D.), Pharmacology And Toxicology

Study of the mechanisms of drug-induced liver injury (DILI) specifically to the isoxazolyl penicillin, flucloxacillin. To determine.

Master'S Degree, Drug Chemistry, Merit

This course provided skills in modern methods used in drug discovery, organic synthetic techniques that can be applied to drug targets.

Bachelor'S Degree, Pharmacology, 2:1

Detailed knowledge of various pharmacological systems was acquired with topics also covering drug metabolism, pharmacokinetics.

Education record