Pathik Sen Email & Phone Number

Boston, Massachusetts, United States

• Developed and implement innovative biomarker assays for clinical studies at Vertex across many disease modalities.
• Developed a novel receptor occupancy assay to support ongoing hematological projects
• Made process improvements on existing assays to pass off to CROs or make compliant with FDA BeST regulations forbio markers, and adherence to industry standards
• Part of the first round process change for a new LIMS system for handling experiment records and inventory
• Created and maintained relationships with external vendorsWork with colleagues in Biomarkers to develop and implement innovative biomarker assays for clinical studies at Vertex.
• Conduct fit-for purpose biomarker assay development and troubleshoot technical challenges across different technologies and disease areas.

Cambridge, Massachusetts, United States

Conducted viral vector characterization and supported method development, comparability studies, and stability studies to inform both 2Seventy’s ongoing studies, research and development, product quality, and in process product characterization.Helped develop methods and process for a novel cell potency assay for platformed product characterization use.

• Running exploratory and routine panels for the Center for Regenerative Medicine. Worked with the Sykes Lab supporting ongoing experiments in cell metabolism and differentiation.
• Validated the use of Salsa6f; a novel, ratiometric genetically encoded Ca2+ indicator in leukaemia progenitor cells for imaging and tracking in-vivo
• Developed a new culturing method for Fucci2a cells in methylcellulose (M3434) and their differentiation with Brequinar and other DHODH inhibitors
• Piloted the use of the new Thermofisher Bigfoot Spectral/Traditional Analyzer and sorter, creating larger panels up to 27 colours
• Ran BSL2+ samples for both analyses and sorting, keeping cells healthy and sterile for downstream use

• Procured patient tumour and blood samples for accessioning, processing and sequencing. Acted as the liaison between Foundation Medicine’s domestic and international partners with various departments within the.
• Helped solid tissue sample collection and mobile phlebotomy, making sure patient material was properly accessioned for analysis
• Collaborated in tandem with medical partners, pathologist offices, and account executives to keep good client relationships
• Acted as the french speaking representative for our Canadian clients, aiding in foreign sample collection

• Worked in the Medina Lab l on the project “Bazedoxfine inhibits STAT3 phosphorylation in Multiple Myeloma Cells”investigating the ability of the drug Bazedoxfine on disrupting the tumour viability. Also helped maintain.
• Applied methods from pancreatic cancer models to find new relevant drug targets of Bazedoxfine in Myeloma models
• Used MM cells lines as a pre-clinical model to demonstrate that Bazedoxifene inhibited cell replication and induced cell death
• Ran ELISA assays to check for the presence of STAT-3 phosphorylation before and after drug treatments
• Maintained cell cultures and made media, ensuring all cells and reagents remained accurately prepared and sterile

University Of Toronto Centre For The Study Of Pain

• Assisted with preparing and updating the Interfaculty Pain Curriculum (IPC), and organizing the associated conference, applying an inter-professional approach to health professions education and healthcare.
• Developed and updated online learning modules and curriculum materials related to opioids for program attendees
• Used software to create surveys and collected the data to use for post conference analysis to inform further curriculum development
• Intensively used excel to coordinate and organize attendees into interfaculty teams, and across buildings

Agrawal Lab For Evolutionary Genetics

• Helped conduct lab research on the general properties of genetic systems. Maintained and used both drosophila and duckweed plant samples.
• Created and maintained habitats to keep drosophila specimens healthy and promote breeding
• Assisted on a project to recreate sexual reproduction in duckweed plants to compare them to usual asexual reproduction methods
• Maintained stock of duckweed samples from domestic, and overseas collection points to keep them ready for analysis

620 University Ave, Toronto, ON M5G 2L7

I was placed as a student aide in the Provincial Drug Reimbursement Programs Unit. During my time here, I was responsible for compiling a directory of sites from which the company received reimbursement forms as well as the relevant contacts at each sites. This directory is used in order to send out pertinent newsletters regarding changes in policies in.

• Worked on a comparison of the MGH In House ISHAGE based Stem Cell Enumeration assay and a new BD Stem Cell Enumeration kit. Shadowed and assisted in general BMT lab duties.
• Analyzed data from Cord blood, autologous, marrow, and allogenic blood samples to determine comparability between the assays
• Observed and helped in the separation of CD34 cells and cryopreservation of samples for later transplant and downstream analysis
• Conducted general lab maintenance to ensure smooth function of the facility and its machines

Masters Of Biomedical Sciences, Biological And Biomedical Sciences

Bachelors

Honours Bachelor Of Science (B.Sc), Cell&Systems Biology

Honours Bachelor Of Science (B.Sc), Human Biology: Global Health