Led a screening group supporting IBD, fibrosis, and immuno-oncology projectsDeveloped a screening cascade supported by both internal and external staffDeveloped flow cytometry assays to measure ligand binding or receptor occupancy

Biochemical assay development and enzyme kinetic characterization for drug discovery:- Targets included ATPases, metallo-hydrolyases, deacetylases, glycosyltransferases, GPCRsProject team co-leader for a hit-finding project:- Identified hits interacting with the enzyme's active siteCo-authored a research proposal that resulted in the initiation of a drug discovery project

Enzyme assay development for DNA topoisomerases and a phospholipid synthetaseEvaluation of drug targets including RNA polymeraseAnalyzed the human serum stability of a biologic protein therapeuticCoordinated in vitro compound testing, protein production, and CRO services

Screened a whole animal infection model and identified compounds that inhibited pathogen virulence or stimulated innate immunity

Developed a whole animal infection model enabling the identification of anti-infective compoundsAnalyzed activity of an antimicrobial covalently conjugated to a multi drug efflux pump inhibitor

Identified and characterized transport factors required for the nuclear export of ribosomal subunitsDetermined that the Cgr1 protein is required for biogenesis of the large ribosomal subunit Determined that the RSC complex (Remodels the Structure of Chromatin), which is involved in gene regulation through the TOR signaling pathway, regulates ribosomal RNA production

Generated monoclonal antibodies by performing tissue culture of hybridoma linesMapped an epitope of a human sperm protein that is a candidate antigen for a contraceptive vaccine for use in humans