Thanyashanthi (Thanya) Nitya-Nootan Email & Phone Number

Mississauga, On, Ca

Hamilton, Ontario, Canada

Hamilton, Ontario, Canada

Lead several projects, development of R&D screening process for identifying new leads, cell model creation and Invitro assay development for Cancer Immunotherapy Research TAC Technology.● Lead the cell model engineering project successfully: Engineering of cell lines required for new target evaluation (Tumor lines and T cell engineering). ● Lead the cell model creation projects for external collaborators successfully.● Lead the generation of TAC01-HER2 in vitro pharmacology data in support of the IND submission (example: Cell model creation, in vitro function and Toxicity assays. ● Complete the screening of new binders TAC constructs and generate data packages for external collabrators● Optimized R&D T cell production and Invitro-cytotoxicity and screening assays.● Development of the R&D screening process for the identification of new TAC leads.● Created ATM, SOPs and IOQ documents for Quality Control department.● Lead the project for new target TAC candidates, and identifying a lead candidate.

Designed, developed, and implemented In-vitro screening assays, leading to characterization of physicochemical, pharmacological, pharmacokinetic, metabolic and toxicological properties of drug candidates in cell-based and cell-free systems using a variety of techniques. Saved cost and improved productivity. Provided first level of interpretation of results. Served a primary contact for contract research organizations (CROs) for study projects. Performed data analysis, report writing, and troubleshooting.• Collaboration with CRO’s on study projects• In-vitro experimental designs, implementation and troubleshooting• Designing and conducting studies to identify the mechanism of action of new molecules• Execute In-vitro studies to determine toxicity of new molecules. • Data analysis and Report writing • Supervise and manage junior members and co-op students

Toronto, Canada Area

Conduct Non-clinical In-vitro studies for different projects: Cell based Toxicity assays, assays to determine mechanism of action of the molecule and screening assays.SWOT AnalysisData Analysis and Report Writing. Excellent Time Management and Project ManagementSpecialties Cell Culture experience: Human Bone marrow cells, Human Fibroblast, Human Keratinocytes, Lymphocytes, Human Periperal Blood Monocyte, Neuronal cells and Mouse Lymphoma Cells and many more.Molecular biology: Tryptophan Catabolism by HPLC, Flow Cytometry, Immunochemistry, Western and Elisa Toxicology assays: MTT assays, WST assays, Cytotox assays, MPP assay, Micro Nucleus assay Protein, DNA, RNA Analysis Computer Skills: Microsoft Word, Excel, Access, Visio, Outlook, Power Point, Sigma plot and Reference Manager, Grantt charts.Other skills:Time ManagementCritical ThinkingProject ManagementLeadership Skills

Ottawa, Canada Area

Completed several non-clinical In-vitro studies (Product characterization).Written SOP for non-clinical departmentDocumentation lead for non-clinical (protocols, SOPs, Equipment SOPs)Cell culture , molecular biology (DNA gels, RNA isolation, Western blots, Immuno-cytochemistry)Purchasing for non-clinical Excellent customer-service, communication and negotiation skills

Cardiovascular Research:Conducted research for cardiovascular related disease.Expression of beta-Camkinase protein, Protein Isolation, Purification, Western Blots, DNA gels, Restriction Digest, molecular and cellular cloning, Fractionization of rabbit skeletal muscle and etc........