Thomas Bohnacker Email & Phone Number

Basel, Bs, Ch

Basel, Bs, Ch

Basel, Ch

Achievements:• Acquisition of Innosuisse funding (108.486 IP-LS; project manager).• Project-based start-up has been incorporated. • Contributor SNF application (10.092.294)Role:• Discovery of PI3K isoform inhibitors with new modes of action for oncology. • Management of CROs (pre-clinical ADME, PK/PD, efficacy, tox).• Generation of data rooms, presentations and reports for investors and due diligences. • Discovery projects on novel PI3K gamma functions in inflammatory diseases

Basel, Bs, Ch

Achievements:• Successful IND filing of the developed compound, clinical trials in oncology ongoing.• Co-author of 4 patent applications.• Presentation of TOLREMO’s science at AACR Annual Meeting 2023.Role:• Line manager and scientific team leader with up to 4 research associates and a scientist.• Lead in biologicl assay development for small molecules in adaptive cancer drug resistance.• Identification and implementation of experimental programs including novel target diseases. • Design, train, supervise and review experimental work of the research team. • Cross-functional development of biomarker, proof-of-concept and mode of action studies.• Contributor to key documents, due diligence data rooms, quality management.

Basel, Bs, Ch

• Discovery of small molecule epigenetic inhibitors against adaptive drug resistance in oncology• Identification, design, and implementation of experimental programs • Identification of novel target diseases thereby also accelerating hit-to-lead efforts• Design, train, supervise and review experimental work of the research team • Biomarker, proof-of-concept and mode of action studies in cross-functional teams• Contribution to patents, presentations, key documents

Basel, Ch

Achievements:• Lead molecule is currently in Phase I/II clinical trials for oncology.• Co-author of 3 patent applications (UniBas/PIQUR therapeutics).• Detailed SAR and differentiation of PI3K inhibitors published in Nature Communications.• 15 peer-reviewed publications in drug discovery, oncology, signalling and cell biology.Role:• Main contributor to preclinical discovery of small molecule kinase inhibitors for oncology (CTI/InnoSuisse Projects with PIQUR Therapeutics).• Assay development for compound screening - high-content microscopy, biochemical, HTRF.• Interactions and management of collaborators’ and CRO activities.• International research collaborations with academia and pharmaceutical companies• Supervision of research associates, PhD students, collaborators and CRO activities• Teaching of medical students at the Medical Faculty, Uni Basel

Barcelona, Barcelona, Es

Cell and Developmental Biology• Investigations on molecular mechanisms of mucin secretion in asthma and colorectal cancer

Basel, Ch

Departement of Biomedicine - Cancer and Immunobiology Group• Research lead on isoform and adapter-specific PI3K signalling and inhibitors in allergy• Contribution to international research collaborations, research funding• Supervision of projects, PhD students and research associates• Teaching of medical students• 2 peer-reviewed publications

Canberra, Australian Capital Territory, Au

student reseach project on de-ubiquitinating enzymes

Doctor Of Philosophy - Phd, Cell Biology

Diplom Biologe (Technical Orientation), Technische Biologie