We endeavor to understand how basic molecular and cellular pathways regulating the biology of potassium-selective ion channels control cellular physiology.Two-pore domain potassium channels (K2P) play a central role in the control of neuronal excitability. By allowing the outward flow of potassium ions, they maintain the cell’s resting membrane potential and counteract depolarization. In the vertebrate nervous system, regulation of K2Ps by second messenger pathways can modify action potential firing, synaptic transmission and network activity. Consistently, K2Ps have been implicated in many neuronal processes including spatial learning, sleep-related neural rhythms, nociception, depression, anaesthesia and epileptic activity. Recently, mutations in K2P channels have been directly linked to human pathologies. K2P channels can be regulated at multiple levels by factors controlling channel expression, biosynthesis, trafficking, membrane insertion, recycling and activity. Such factors can alter the number and the function of K2P channels and therefore profoundly impact neuronal physiology. Yet, only few specific regulators of K2Ps are known to date. We use genetic screening strategies in the nematode Caenorhabditis elegans to identify novel genes and conserved cellular processes that regulate the biology of K2P channels.Specifically, we1/ conduct large-scale genetic screens to identify novel genes that regulate K2P channels.2/ functionally characterize conserved regulators of K2P channels in C. elegans and heterologous systems.3/ develop innovative strategies to study conserved K2P channels in C. elegans.Specialties: Biology, molecular neurosciences, electrophysiology, parasitology, antihelminthic drugs, parasitic nematodes, acetylcholine recepetor, nicotine, levamisole, xenopus oocyte.