Thomas Heel, Ph.D. Email & Phone Number

Los Angeles, Ca, Us

Thousand Oaks, California, Us

Leading a team of scientists to develop a production process for a biological from proof of concept to pilot scale.Select accomplishments:• Successfully produced the first product batch within specifications for animal studies.• Participated in Interact and Pre-IND FDA meeting

Santa Monica, Ca, Us

Led executive team to manage small molecule active ingredient portfolio exceeding $10M in revenue for regulated markets in B2B environment.Select accomplishments:• Coordinated strategic initiatives to create the largest portfolio by revenue and profit within Provivi.• Managed global cross-functional team to introduce 3 new small molecule active ingredients in regulated markets globally.• Led customer centric product development efforts to expand product portfolio, accentuating innovative sustainable synthesis technologies.

Santa Monica, Ca, Us

Developed fermentation and downstream processes for commercial manufacturing of small molecule active ingredients. Select accomplishments:• Received EPA Green Chemistry Award.• Developed and implemented companywide fully integrated PowerBI cost of manufacturing (CoM) model across active ingredient portfolio.• Performed comprehensive, manufacturing process and techno-economic analysis resulting in up to 50% cost of manufacturing (CoM) reduction and ~20% lead time reduction.• Foundational work for Series B-C

Santa Monica, Ca, Us

Active Ingredient Synthesis Lead managing a cross-functional team to scale and commercially manufacture the active ingredients for Fall Army Worm (FAW) end use products. Select accomplishments:• Leveraged matrix organization to coordinate the scale-up and launch of the first two small molecule active ingredients for regulated markets in time at forecasted cost.• Implemented project management tools to create critical path to launch, establish project scope, monitor timelines, cost, assess risks and performance.

Santa Monica, Ca, Us

Combined genetic and metabolic engineering strategies with bioassay screening expertise to design and manipulate biological pathways for commercial production of desired compounds.Select accomplishments:• Engineered second generation biosynthesis lead strain for production of fatty alcohol, exceeding target milestone by 6-fold.• Developed promoter library with protein expression ranging from 17% to 130% compared to standard TEF promoter. • Foundational work for 8 granted and 3 pending patent applications and Series A funding. • Authored IDFs, SOPs, technical reports and presentations

Pasadena, Ca, Us

Postdoctoral Fellow in the laboratory of Nobel Laureate Prof. Frances Arnold. Combined protein engineering strategies with expression tuning in target host organisms for biocatalytic applications.Select accomplishments: • Crystallized world's first Histidine ligated P450 enzyme.• Work led to 2 first and 2 co-author publications in peer-reviewed top-tier journals with cover in JACS and inside cover in Angewandte Chemie.

Graz, Styria, At

Worked at the interface between academia and the biopharmaceutical industry to develop novel expression and secretion systems for biopharmaceutical peptides in E. coli.

Postdoctoral Fellow, Protein Engineering, Biocatalysis

Doctor Of Natural Sciences (Dr. Rer. Nat.)

Master Of Science - Ms, Molecular Biology

Bachelor Of Science - Bs, Biology

Doctor Of Philosophy - Phd