Thomas J. Bell Email and Phone Number
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As the Chief Scientific Officer, I am responsible for developing new and existing strategic partner relationships with scientific, corporate, government and philanthropic entities to advance NDRI's mission.I have served in a variety of capacities at NDRI since joining the organization in 2010. Prior to my current role, I served as the Senior Vice President of Strategic Initiatives and Vice President of Operations/Director of Biorepository and Scientific Services. In addition to having more than 20 years of experience in biomedical research, I instructed summer courses at Cold Spring Harbor Laboratories for over 10 years. I have published numerous articles, patents, abstracts and book chapters in the fields of neurophysiology and molecular neuroscience. My training and education includes a National Institutes of Health (NIH)-funded postdoctoral fellowship in the Department of Systems Pharmacology and Translation Therapeutics at University of Pennsylvania School of Medicine and a PhD from the Division of Biology and Medicine at Brown University. Experimental expertise: electrophysiological recordings, single cell gene expression, single cell RNAseq, RNA amplification, immunocytochemistry, in situ hybridization, siRNA gene silencing, gene transfection, cell-based assay development, small and large molecule drug discovery .
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Chief Scientific OfficerNdri - National Disease Research Interchange Feb 2023 - PresentPhiladelphia, Pennsylvania, Us
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Senior Vice President Of Strategic InitiativesNdri - National Disease Research Interchange Mar 2020 - Feb 2023Philadelphia, Pennsylvania, UsKey responsibilities- developing new and existing strategic partner relationships with scientific, corporate, government, and philanthropic entities to advance NDRI's mission.
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Vice President Of Operations And Director Of BiorepositoryNdri - National Disease Research Interchange 2017 - Mar 2020Philadelphia, Pennsylvania, UsPrimary responsibilities- strategic development, execution, day-to-day oversight of NDRI’s Operations Division that contained four departments (Scientific Services, Fulfillment, Tissue Source Site Management and Logistic Management) and a CAP-accredited Biorepository.
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External Scientific AffairsCytosorbents 2015 - 2017Princeton, New Jersey, UsCytoSorbents (NASDAQ: CTSO); a publicly-traded, critical care immunotherapy company using blood purification to control deadly inflammation in life-threatening diseases such as sepsis, burn injury, and trauma. The Company's flagship product, CytoSorb®, is a highly efficient cytokine adsorber approved in the European Union to fight cytokine storm in critical illnesses that could otherwise cause massive inflammation and organ failure, the leading cause of death in the ICU. As the Associate Director of External Scientific Affairs, my responsibilities included:• Lead external scientific collaboration with academic institutes, contract research organizations, government organization and companies• Collaborate and communicate with scientific leaders• Develop and write experimental research protocols, reports, white papers, and other related projects• Make presentations and represent the company at scientific conference and meetings• Manage and negotiate contracts (CRADA, SRA, MTA, NDA)• Support business development from a scientific prospective• Collaborate with internal R&D resourcesExternal Funding Opportunities• Oversee internal and external grant submission process, including identification of new grants or grant continuation opportunities, grant submission planning, application development, and submission on funded grant programs• Management and mentoring of PhD-level reports that are responsible for grant applications and project management -
Systems Pharmacology And Translational TherapeuticsPenn Medicine, University Of Pennsylvania Health System 2008 - 2017Philadelphia, Pa, UsAs a Research Associate, my studies focused on demonstrating that ion channel splice variant expression profiles and physiologies are in part regulated by cytoplasmic splicing and intron retention. RNAseq, in situ hybirdization, pooled-dendrite RT-PCR were performed to show the presence of the splice variant-specific intron-containing transcripts in hippocampal dendrites. siRNA-treatments, splice variant specific immunostaining and current clamp analysis were used to show splice variant-specific intron-containing transcripts functionally contributed to the burst firing properties of hippocampal neurons. -
Director Of Scientific ServicesNdri - National Disease Research Interchange Jul 2010 - Jul 2015Philadelphia, Pennsylvania, UsAs the Director of Scientific Services, my responsibilities included: 1) overseeing all activities related to the development and implementation of new research projects, 2) conducting ongoing educational training programs to support and improve NDRI's services, 3) serving as a scientific resource for external researchers and key business partners as needed, 4) directing the college internship program and 5) leading our Community Media Committee.
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Cold Spring Harbor Laboratory, InstructorCold Spring Harbor Laboratory 2007 - Jun 2015Cold Spring Harbor, New York, UsOver twenty years ago, the aRNA amplification and single cell RT-PCR procedures were first used to couple transcriptomics and functional analysis at the single cell level. Since their initial reports, the aRNA amplification and single cell RT-PCR procedures are still the most universally used methods by scientists to connect single cell transcriptional fingerprints and physiological phenotypes. As an instructor for Cold Spring Harbor Laboratory summer courses, I teach both techniques along with live and fixed single cell collection methods via pipette capture and laser capture microdissection. -
Adjunct ProfessorThomas Jefferson University Hospitals Jan 2005 - Jun 2015Philadelphia, Pa, UsAs an adjunct faculty member for Thomas Jefferson University, I designed and directed graduate/ undergraduate level courses in human genetics and advanced molecular techniques for the School of Health Sciences. -
Adjunct ProfessorRutgers University Jan 2004 - May 2015New Brunswick, Nj, UsAs an adjunct faculty member for Rutgers University, I designed and directed graduate/ undergraduate level courses in neuroscience and advanced molecular techniques for the School of Health Sciences. -
Postdoctoral FellowshipUniversity Of Pennsylvania Apr 2004 - Jun 2008Philadelphia, Pa, UsThis hearing loss is permanent in humans and mammals because hair cells are not spontaneously replaced. In other animals such as birds, this is not the case. Damage to the avian cochlea evokes proliferation of supporting cells and the generation of functionally competent replacement hair cells. Signal transduction pathways are clinically useful as potential therapeutic targets, so there is significant interest in identifying the key signal transduction pathways that regulate the formation of replacement hair cells. By a combination of biochemical, imaging and pharmacological analyses, my work identified 2 key processes that mediate auditory hair regeneration: 1) cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. -
Predoctoral FellowshipBrown University Sep 1999 - May 2004Providence, Rhode Island, UsN-type calcium channels are critical for pain transduction. Inhibitors of these channels are powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable actions in other regions of the nervous system. By a combination of functional patch clamp and single cell molecular analyses, my studies showed that the dorsal root ganglia-specific splice isoform of the N-type channel is preferentially present in neurons that contain nociceptive markers. This unique splice isoform of the N-type channel could represent a novel target for pain management. -
Research SpecialistUniversity Of Pennsylvania Health System Jun 1995 - Sep 1999Philadelphia, Pa, UsIn auditory hair cells large conductance (BK) calcium-activated K channels play a key role in frequency tuning of hair cells in several species. Frequency tuning enhances the release of neurotransmitter from hair cells by fine-tuning the membrane properties of hair cells to respond optimally to a particular sound frequency. The cell-specific tuning of hair cells is achieved in part by varying the functional properties and current densities of the BK channels. Functional differences among BK channels can arise from alternative splicing of the KCNMA1 gene or via modulation by auxiliary beta-subunits and signal proteins such as PKA. Here, I worked on team that constructed cDNA libraries and cloned BK channel splice variants from the avian auditory epithelium. Next, we used single cell RT-PCR to demonstrated that multiple BK channel splice variants are differentially expressed along the tonotopic axis of the chick basilar papilla.
Thomas J. Bell Skills
Thomas J. Bell Education Details
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Brown UniversityNeurobiology And Neurosciences -
University Of PennsylvaniaNeuroscience
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Rutgers UniversityNeuroscience
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Rutgers UniversityGeneral
Frequently Asked Questions about Thomas J. Bell
What company does Thomas J. Bell work for?
Thomas J. Bell works for Ndri - National Disease Research Interchange
What is Thomas J. Bell's role at the current company?
Thomas J. Bell's current role is Chief Scientific Officer.
What is Thomas J. Bell's email address?
Thomas J. Bell's email address is tj****@****ers.edu
What is Thomas J. Bell's direct phone number?
Thomas J. Bell's direct phone number is +121555*****
What schools did Thomas J. Bell attend?
Thomas J. Bell attended Brown University, University Of Pennsylvania, Rutgers University, Rutgers University.
What skills is Thomas J. Bell known for?
Thomas J. Bell has skills like Neuroscience, Molecular Biology, Biochemistry, Cell Biology, Stem Cells, Electrophysiology, Neurophysiology, Drug Discovery, Molecular Cloning, Biopharmaceuticals, Molecular And Cellular Biology, Neuroimaging.
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