Thomas Sears

Thomas Sears Email and Phone Number

Chicago, IL, US
Thomas Sears's Location
Chicago, Illinois, United States, United States
About Thomas Sears

I aim to contribute to the scientific understanding of cancer through research in both basic and translational sciences. Currently, I am a postdoctoral scholar at the Feinberg School of Medicine, Northwestern University performing neuro-oncology research under the mentorship of Dr. Craig Horbinski. Upon transitioning from my postdoc, I strive to acquire a faculty position at a leading research institution. My broad interests include the molecular and cell biology behind cancer initiation, promotion, and progression, and how this biology can be exploited for therapeutic purposes. In particular, I am interested in looking at epigenetic dependencies in isocitrate dehydrogenase (IDH) mutant glioma that may unveil novel therapeutic strategies against this unique subtype of brain cancer.

Thomas Sears's Current Company Details
Northwestern University - The Feinberg School of Medicine

Northwestern University - The Feinberg School Of Medicine

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Postdoctoral Researcher
Chicago, IL, US
Thomas Sears Work Experience Details
  • Northwestern University - The Feinberg School Of Medicine
    Postdoctoral Researcher
    Northwestern University - The Feinberg School Of Medicine
    Chicago, Il, Us
  • Northwestern University - The Feinberg School Of Medicine
    Postdoctoral Researcher
    Northwestern University - The Feinberg School Of Medicine Sep 2020 - Present
    Chicago, Illinois, United States
    Postdoctoral Fellow in the Horbinski Lab
  • University Of California, Davis
    Etx 102B Graduate Teaching Assistant
    University Of California, Davis Mar 2015 - Sep 2020
    Davis, Ca
    Head teaching assistant (TA) for ETX 102B: Quantitative Analysis of Environmental Toxicants. Led lab sections with experiments developed to teach students how to analyze various environmental media for toxicants. Concepts ranged from sample preparation to chromatography (LC and GC) to instrumental analysis (mass spectometry, VWD, NPD, etc).
  • University Of California, Davis
    Phd Candidate-Woolard Lab
    University Of California, Davis Jul 2017 - Jul 2020
    Davis, Ca
    My research in the Woolard lab centers around neuro-oncology and pathology of glioma. Current projects include investigating mechanisms of glioma tumor recurrence and assessment of epigenetic drug targets in isocitrate dehydrogenase (IDH) mutant glioma.
  • University Of California, Davis
    Etx 103A Teaching Assistant
    University Of California, Davis Jan 2016 - Mar 2019
    Davis
    Head teaching assistant (TA) for ETX 103A: Biological Effects of Toxicants. I helped teach students the basic concepts of toxicology in the context of environmental toxicants. Briefly, we discussed basic toxicokinetics, toxicogenomics, and toxicant mechanisms of action within the framework of biochemistry, molecular biology, cell biology, and physiology. My role as TA was to assist the professor and students with various facets of the class. This included developing and going over practice… Show more Head teaching assistant (TA) for ETX 103A: Biological Effects of Toxicants. I helped teach students the basic concepts of toxicology in the context of environmental toxicants. Briefly, we discussed basic toxicokinetics, toxicogenomics, and toxicant mechanisms of action within the framework of biochemistry, molecular biology, cell biology, and physiology. My role as TA was to assist the professor and students with various facets of the class. This included developing and going over practice problems with the students during discussion sections, holding office hours and exam reviews, assisting development of exam questions, and grading of exams. I also presented my own lectures on the topics of xenobiotic metabolism and cardiotoxicity.Quarters TAd: Winter 2016, Winter 2018 Show less
  • Uc Davis
    Graduate Student Researcher- Angelastro Lab
    Uc Davis Sep 2015 - Jul 2017
    Davis, Ca
    Dr. Angelastro's lab aims to develop novel dominant-negative peptides with anticancer activity. My project involved developing an ATF5-targeted gene therapy approach for treating glioblastoma with a dominant-negative ATF5 transgene. This was an alternative approach to the systemically-deliverable dominant-negative peptides that have already been developed by the Angelastro lab. The objective of this research was to assess the promise of a 1st generation adenoviral vector to deliver… Show more Dr. Angelastro's lab aims to develop novel dominant-negative peptides with anticancer activity. My project involved developing an ATF5-targeted gene therapy approach for treating glioblastoma with a dominant-negative ATF5 transgene. This was an alternative approach to the systemically-deliverable dominant-negative peptides that have already been developed by the Angelastro lab. The objective of this research was to assess the promise of a 1st generation adenoviral vector to deliver dominant-negative ATF5 prior to development of a much more costly and laborious oncolytic adenovirus construct. Show less
  • Uc Davis
    Student Research Assistant-Rice Lab
    Uc Davis Apr 2013 - Aug 2014
    Davis, Ca
    Was involved in research regarding:The effects of sodium borate on the gene and protein expression of cross-linking enzyme TGM1 in keratinocyte cell cultures.Effects of heavy metals i.e. arsenic, antimony, copper, etc. on bone morphogenetic protein-6 (BMP-6) signal transduction pathways involved in keratinocyte differentiation.
  • Transportation And Parking Services (Taps)
    Student Assistant I
    Transportation And Parking Services (Taps) Sep 2010 - Apr 2013
    Davis, Ca
    Conducted campus bicycle services ie impounding deserted bikes, removing broken locks from licensed bicycles for customers, work the campus information kiosks.

Thomas Sears Education Details

Frequently Asked Questions about Thomas Sears

What company does Thomas Sears work for?

Thomas Sears works for Northwestern University - The Feinberg School Of Medicine

What is Thomas Sears's role at the current company?

Thomas Sears's current role is Postdoctoral Researcher.

What schools did Thomas Sears attend?

Thomas Sears attended University Of California, Davis, University Of California, Davis, Sacramento City College.

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