* Directly managed a group (6 individuals) responsible for computational generation strategy, planning and execution for 20 discovery-stage programs* Assessed targets and identified strategic opportunities to maximize the unique biological/clinical value the company’s technology can deliver* Initiated and advocated pivot to high-throughput screening and data collection (e.g. designed libraries, NGS)* Scaled group operating model to support growing business need* Oversaw development of ML-based computational design algorithms and applied pipeline generation

* Directly led or led leaders of multiple early stage therapeutic discovery efforts that resulted in de-novo-designed therapeutic leads spanning 5 different MOA axes* Assessed early discovery protein design targets and defined rationale, opportunity, prioritization and strategy * Established and directed a mixed computational and experimental group focused on early discovery of de novo designed protein therapeutics, including computational de novo protein design, protein optimization, clonal screening, library-based screening, NGS data processing and protein characterization.* Actively developed and advanced design concepts that leverage structure-based design principles to address therapeutic challenges* Developed novel design strategies that applied both novel and existing ML-based modeling and wet lab experimental methods to increase protein design capability and shorten timelines

* Led cross-functional program that designed and developed a potent and escape-resistant SARS-CoV-2 inhibitor lead candidate molecule in 69 days from idea to experimental result* Built computational protein design platform for de novo design of protein therapeutics

Lead in:Modeling, simulation and design of mixed organic/protein systemsSequencing workflow/pipeline developmentNext gen sequencing assay design and development efforts

Macromolecular modelingProtein design and engineeringBiochemistryEnzymology

Computational protein design

Authored 8 publications related to enzyme catalytic mechanisms and inhibitor designDeveloped two in vitro high-throughput screening assaysIdentified promising small molecule lead compounds for cancer therapy by high throughput screening of thousands of compounds.Designed and conducted experiments to demonstrate mechanistic similarity within the pentein superfamily by showing that one enzyme is capable of catalyzing two different reactions.Investigated the mechanism and function of potentially important protein targets found in tuberculosis and other micro-organisms.Determined the mechanistic basis for reviving a catalytically “dead” enzyme using small molecules, and investigate the factors which lead to reaction partitioning and enzyme evolution.Directly supervised 15 graduate rotation students and three undergraduates in the lab.Introduced small-molecule docking and virtual screening to the Fast LabTaught weekly review sessions and led discussions for three undergraduate biochemistry courses.

Chaired the Networks for Exploration Team, a NASA Glenn Research Center-wide working group chartered to explore and develop technology concepts and architectures for lunar surface networks.Wrote NASA intramural proposal in collaboration with the Networks for Exploration Team.Edited and reviewed NASA space communication documents.Reviewed extramural proposals from academia and industry for space communications technologies for exploration missions.Developed integrated communication architectures and scenarios to support safe, reliable and affordable exploration missions to lunar and planetary surfaces, in collaboration with the in-space network development ongoing in the Space Communication Architecture Working Group. Performed analysis, through simulation and emulation, of network system architectures, protocols, and technologies for space communications to support future NASA lunar exploration missions.Researched improvements in space- and surface-based routing schemes.

Supervised newspaper staff consisting of approximately 50 people with diverse backgrounds and skill sets.Directed content generation and production for weekly newspapers.Reorganized news production process to improve efficiency and reduce time per issue.Conducted complete overhall of computer networksEffected business initiatives to remove dependence of the newspaper on university funding.Collaborated to formulate Case Western Reserve University's master plan as a member of the student housing committee.