Thomas Prince Email & Phone Number

Danville, Pa

• Directed mechanism of action studies on novel hetero bi-functional inhibitor molecules for the treatment of cancer• Established and maintain research collaborations with academic and government laboratories• Initiated and managed experimental work flows with international contract research organizations (CROs)• Prepared and managed 15+ patent portfolio of molecular therapeutics focused on targeted protein degradation (TPD), molecular chaperone inhibition, and mutant KRAS inhibition

Danville, Pennsylvania, United States

• Screened, identified and characterized cancer small molecule drug combinations that disrupt proteostasis and inhibit initiation of the cellular stress response • Analyzed the biochemical effects of heat shock protein 90 (HSP90) phosphorylations and germline variants• Studied the role and effect of heat shock factor 1 (HSF1) overexpression in cancer • Analyzed the biochemical effects of HSF1 germline variants• Identified the oncogenic potential of HSF1 relationship to genes on Chromosome 8q• Carried out mouse xenograft studies to test effectiveness of drug combination targeting HSP90 and HSP70• Mentored and trained 2 undergraduate researchers, a resident physician, and a technician• Published 11 research papers

Bethesda, Maryland

• Developed assays and reagents for analyzing cancer relevant protein-protein interactions• Instructed students and younger researchers on cell and molecular biology techniques• Initiated research projects aimed at understanding the cellular stress response in cancer• Maintained reagent inventories• Built DNA construct library • Managed data and presentations• Published 13 research papers

Greater Boston Area

• Identified novel post-translational modifications on Heat Shock Factor 1 that affected nuclear localization • Created in vitro protein-protein interaction system• Developed understanding of the stress response in cancer and aging• Initiated project to analyze the gene promoter of the molecular chaperone, CDC37• Coordinated laboratory relocation and setup• Wrote, reviewed and edited manuscripts for publications• Published 9 research papers

Richland/Kennewick/Pasco, Washington Area

• Analyzed the effect of Her2/ERBB2 over-expression on protein shedding/secretion and signal transduction in breast cancer• Systems Biology Fellowship

Stillwater, Ok

• Conducted research on the role of molecular chaperones and kinases in cellular signal transduction • Studied protein structure folding, protein-protein interactions, and protein-drug interactions• Published 8 research papers• Trained undergraduate researchers in basic molecular biology methods• Managed day-to-day operations of the research laboratory

Phd, Biochemistry And Molecular Biology

Activities and Societies: Biochemistry and Molecular Biology Graduate Student Association: Founding Member• Dissertation: Defined.

Bs, Biochemistry

Activities and Societies: Pi Kappa Alpha, Social Chairman; Delta Nu Alpha-Biochemistry Club, Founding Member>Research Project.