Thos O'Brien Email and Phone Number
Research scientist with early stage drug discovery experience and project management experience. Currently responsible for cell line engineering at Omnispirant Therapeutics, engineering Stem Cells to deliver novel cargoes via Extracellular Vesicles. Previously worked in the Centre for Chromosome Biology in the University of Galway under the supervision of Dr. Robert Lahue, developing a new cell based in vitro assay for detecting tri-nucleotide expansions. Was a project leader at Charles River Laboratories in their GMP accredited Biosafety, Cell Based Assays and Virology Department. Responsible for the project management of GMP standard tech transfers of new assays from commercial clients. Previously worked at Fusion Antibodies, developing a mammalian display platform for antibody discovery. Worked at the Roche Innovation Centre Zurich (Roche Glycart) in the cell and molecular technology department, developing biological tools to support the ongoing research there. Engineering tumor cell lines, immune cells and organoids via viral systems and transposon systems, as well as CRISPR engineering to create knock outs and for targetted integration of transgenes. Experienced in 2d and 3d cell culture. My work history to date has had a large emphasis on the following topics: early stage biologics drug discovery, mammalian cell line engineering and cell culture, genomics, biomedical imaging, medical devices spectroscopy, optics, biochemistry and regenerative medicine. I have been exposed to many different technical fields and have performed very well in them. I am a person who contributes positively to any professional environment.I am always happy to make new connections on LinkedIn.
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Principal Research Associate In Target And Disease Biology GroupRocheSwitzerland -
Senior ScientistOmnispirant Limited Oct 2023 - PresentGalwayResponsible for cell line engineering at OmniSpirant Therapeutics, a company developing lung targeting therapeutics based on inhaled bioengineered stem cell exosomes (extracellular vesicles). Engineering stem cells, running bioreactors and harvesting EV's all fall under my remit. -
Research AssociateUniversity Of Galway May 2022 - Oct 2023Centre For Chromosome Biology, Department Of Biochemistry, Biomedical Sciences BuildingWorking under Dr. Bob Lahue to develop a tri-nucleotide repeat expansion assay as part as of project with other academic and commercial partners. -
Project LeaderCharles River Laboratories Oct 2021 - Mar 2022Ballina, County Mayo, IrelandIn a GMP environment, responsible for drawing up study plans and implementing the studies, researching and developing new methodologies as per client requirements or tech transfer of existing client processes onsite. Also responsible for stakeholder management, contributing to the generation of new quotations for clients and managing weekly and monthly sales figures for various studies. -
Senior Scientist Library DiscoveryFusion Antibodies Oct 2020 - Oct 2021BelfastDeveloping and scaling up a mammalian display platform for antibody discovery.Carrying out RCA on issues, proposing and testing alternative solutions. Conjugating proteins and setting up Flow Cytometry sorting strategies. Also responsible for creating and maintaining ELN templates. -
Senior Research AssociateRoche Glycart Ag Jan 2017 - Apr 2020Zürich Area, SwitzerlandEngineered stable mammalian cell lines and immune cells in order to develop biological tools which supported ongoing research mainly in the fields of cancer immunotherapy and neuroscience. I modified stable tumour cell lines to generate new cell lines (via transductions or transfections) and also immortalized cell lines and created knock out cell lines using CRISPR Cas..
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Master Thesis InternRoche Feb 2016 - Sep 2016Penzberg, GermanyI worked in the cell culturing department of the Pharma Research and Development division. Specifically culturing CHO cells in 2L stirred bioreactors. The department is responsible for clone evaluation. My expertise lies in up stream processing and I was responsible for designing and testing a CHO stress fermentation protocol. The purpose of this was to better evaluate the suitability of clones in terms of their scalability and suitability for cultivating in large scale bioreactors.As… Show more I worked in the cell culturing department of the Pharma Research and Development division. Specifically culturing CHO cells in 2L stirred bioreactors. The department is responsible for clone evaluation. My expertise lies in up stream processing and I was responsible for designing and testing a CHO stress fermentation protocol. The purpose of this was to better evaluate the suitability of clones in terms of their scalability and suitability for cultivating in large scale bioreactors.As well as carrying out the basic research and Design of Experiments, I was responsible for the preparing, automation, running, sampling and documenting of 8 x 2L glass bioreactors, as well as all of the data analysis. I integrated a number of in-line sensors into the fermenters (BlueSens for off-gas analysis, BioPAT for glucose and lactate monitoring), as well as DeltaV control for automating the fermentations. Show less
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Biochemical Engineer2M Engineering Ltd Mar 2010 - Feb 2015Veldhoven, The Netherlands.At 2M Engineering, I was responsible for the chemical and biochemical aspects of projects being run in-house. I was particularly involved with two projects of note, the first being the development of a best-in-class blood separation device for the processing of Platelet Rich Plasma, the second project being the development of a non-invasive glucose monitor. Details of these are provided in the projects section. I have mentored a number of interns and have been involved with preparing funding… Show more At 2M Engineering, I was responsible for the chemical and biochemical aspects of projects being run in-house. I was particularly involved with two projects of note, the first being the development of a best-in-class blood separation device for the processing of Platelet Rich Plasma, the second project being the development of a non-invasive glucose monitor. Details of these are provided in the projects section. I have mentored a number of interns and have been involved with preparing funding applications for projects.I first worked at 2M Engineering Ltd as an intern for 6 months during my Industrial Biochemistry degree. On completion of the internship, I returned to the University of Limerick, but continued working for 2M Engineering Ltd while in Ireland. My Final Year Project was an investigation into suitability of absorbance spectroscopy for non-invasive glucose detection that I carried out on behalf of 2M Engineering Ltd. Following my final exams, I returned to the Netherlands to continue working for 2M Engineering Ltd. Show less -
Evening ManagerThe Good Intent Pub Jun 2008 - Sep 2008London, United KingdomAs the evening manager, I was responsible for the running of the pub from 3 pm to closing time. During this time, I supervised the bar staff, and ensured that it was well stocked. I ensured that there was sufficient change in the tills. After closing, I was responsible for locking up, cleaning and cashing up the till.
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Operations Branch OfficerIrish Naval Service Sep 2003 - Apr 2007Haulbowline, IrelandAs an Operations Branch Officer in the Naval Service, I had to demonstrate leadership daily. My work was mainly focused on navigation and fishery protection, but also covered gunnery. I held my own watch on two ships, the L.E. Emer and the L.E. Niamh, and was involved in a number of search and rescue operations. During my time in the Naval Service, I completed a 30 hour Spanish language course and a 30 hour french language course. I also recruited extensively for the Naval Service, at careers… Show more As an Operations Branch Officer in the Naval Service, I had to demonstrate leadership daily. My work was mainly focused on navigation and fishery protection, but also covered gunnery. I held my own watch on two ships, the L.E. Emer and the L.E. Niamh, and was involved in a number of search and rescue operations. During my time in the Naval Service, I completed a 30 hour Spanish language course and a 30 hour french language course. I also recruited extensively for the Naval Service, at careers fairs and visiting schools. I left with the rank of Ensign. Show less
Thos O'Brien Skills
Thos O'Brien Education Details
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Biotechnology -
University Of LimerickHonor Degree -
National Maritime College Of IrelandNautical Science
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John The Baptist Secondary SchoolI Achieved An Honour Grade In All Of My Subjects.
Frequently Asked Questions about Thos O'Brien
What company does Thos O'Brien work for?
Thos O'Brien works for Roche
What is Thos O'Brien's role at the current company?
Thos O'Brien's current role is Principal Research Associate in Target and Disease Biology Group.
What schools did Thos O'Brien attend?
Thos O'Brien attended Mannheim University Of Applied Sciences, University Of Limerick, National Maritime College Of Ireland, John The Baptist Secondary School.
What are some of Thos O'Brien's interests?
Thos O'Brien has interest in Skiing, Yoga, In May 2011, In September 2008, My Interests Include Reading, North America, Asia, Africa, Mountain Biking, Ice Skating.
What skills is Thos O'Brien known for?
Thos O'Brien has skills like Biochemistry, Lifesciences, Spectroscopy, Biotechnology, Research, Engineering, Microsoft Office, Pcr, Microscopy, Molecular Biology, Medical Devices, Chemistry.
Who are Thos O'Brien's colleagues?
Thos O'Brien's colleagues are Jenny Sabogal Rodríguez, Thevika Rani Ramasami, Thiru Ponnusamy, Linda Soley Finnsdottir, Rafaela Souza, Emine Ayhan, Katharina Schneider.
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Thos. O'Brien
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