Thomas Sawyer

Thomas Sawyer Email and Phone Number

Managing Editor @ Peptide Drug Hunting Consortium
Dunedin, FL, US
Thomas Sawyer's Location
Dunedin, Florida, United States, United States
Thomas Sawyer's Contact Details

Thomas Sawyer personal email

n/a
About Thomas Sawyer

Scientific researcher with experience in protein structural biology and pharmaceutical R&D. Specialized knowledge in glycoprotein purification, glycolipid biochemistry, and X-ray crystallography. Skilled in project management and professional presentations. Interests in science communications and bioethical writing.

Thomas Sawyer's Current Company Details
Peptide Drug Hunting Consortium

Peptide Drug Hunting Consortium

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Managing Editor
Dunedin, FL, US
Thomas Sawyer Work Experience Details
  • Peptide Drug Hunting Consortium
    Managing Editor
    Peptide Drug Hunting Consortium
    Dunedin, Fl, Us
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  • Helix Biostructures
    Senior Scientist - Structural Biology
    Helix Biostructures Mar 2023 - Present
    Indianapolis, In, Us
    – Regularly collect data at X-ray synchrotron facilities worldwide on 100+ crystals persession.– Protein X-ray structure data reduction, refinement, model-building, and quality control.– Technical Report Writing– Molecular Modeling
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  • Goodscience Consulting
    Founder & Principal Consultant
    Goodscience Consulting May 2022 - Present
    Sole proprietor providing structural biology, scientific writing, and virtual research support to clients.– Protein-Protein, Protein-Peptide, Protein-Small Molecule Structural Biology– Protein drug target validation/modeling and targeted structure-based compound screening.– Assist project managers with drug pipeline testing assay development and data analysis.– Liaison between biotech/pharma clients and contract research organizations.– Propose novel peptide drug candidates or analogs for synthesis and testing.– Write scientific/technical reports alongside client scientific teams.– Actively engage in high-level client scientific and/or strategy meetings.
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  • University Of Massachusetts Amherst
    Doctoral Candidate
    University Of Massachusetts Amherst Aug 2014 - May 2022
    Amherst, Massachusetts, Us
    –Expressed, purified, and executed various biochemical, biophysical, and structural studies on the human lysosomal sphingolipid activator protein B (SapB) and hydrolase α-galactosidase A (GLA).–Determined the break-through structure of the SapB:GLA complex, with implications for the study of Fabry Disease and other similar lysosomal glycoproteins. –Solved the first structures of SapB in the presence of a glycosphingolipid and detergent.–Designed 40 DNA plasmids to express a variety of proteins for internal lab research in collaboration with CROs like Genscript (Piscataway, NJ). Established Expression Systems (Davis, California) as an insect-cell media resource and consulted with scientific officers to enhance internal protein production pipelines.–Lead trainer of the Biophysical Characterization Core Facility in various crystallographic, FPLC, and microscale thermophoresis machines.–Mentored several undergraduate researchers in project management, experimental design and execution, and interpretation of results which led to departmental honors theses recognitions. –Teaching assistant, 3.5 years: Real World Biochemistry & Molecular Biology (394RI)–integrative team-based learning covering topics of genetic technologies and their bioethical implications; Senior Honors Seminar (491H)–emphasis on written and oral communication of scientific literature; Elementary Biochemistry (420)–surveying the structure and function of biologics with relation to other disciplines.–Gave professional talks for the Chemical-Biology Interface, Biotech tAles, and UMass Life Science seminars.
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  • The University Of Texas At Austin
    Research Assistant
    The University Of Texas At Austin Aug 2013 - Feb 2014
    Austin, Tx, Us
    Designed novel ubiquitinated polypeptide substrates to study the selectivity of the eukaryotic proteasome for protein degradation.
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  • Ariad Pharmaceuticals, Inc.
    Discovery Biology Intern
    Ariad Pharmaceuticals, Inc. May 2013 - Aug 2013
    Cambridge, Massachusetts, Us
    Performed target-validating, cell-based viability and programmed cell death assays testing several anti-cancer clinical compounds targeting the epigenetic enzyme enhancer of zest 2 protein.
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  • Aileron Therapeutics
    Research Assistant
    Aileron Therapeutics May 2012 - Aug 2012
    Boston, Ma, Us
    Synthesized hundreds of novel stapled peptides for drug discovery. Performed biological screening of de-novo stapled α-helical peptides.
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  • Aileron Therapeutics
    Research Assistant
    Aileron Therapeutics Mar 2011 - Aug 2011
    Boston, Ma, Us
    Developed a comprehensive scientific literature database to establish an internal knowledge engine to support R&D programs.
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  • Northeastern University
    Biophysics Intern
    Northeastern University May 2009 - Aug 2009
    Boston, Ma, Us
    Developed a pharmacophore model using Schrödinger Maestro Suite to perform QSAR analysis of endocannabinoid enzyme inhibitors for neurodegenerative drug discovery.
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  • Aileron Therapeutics
    Organic Chemistry Intern
    Aileron Therapeutics May 2008 - Aug 2008
    Boston, Ma, Us
    Synthesized novel α-methylated amino acids for incorporation into stapled peptides.
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  • Umass Medical School
    Cancer Biology Intern
    Umass Medical School May 2007 - Aug 2007
    Worcester, Ma, Us
    Investigated integrin and growth factor signaling pathways in prostate cancer mouse models.
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Thomas Sawyer Skills

Philosophy Of Science Writing Powerpoint Moral Psychology Drug Design Latin Public Speaking Cell Biology Biology Consumer Electronics Chemistry Teaching Biotechnology English Macintosh Applications Cell Culture Outlook Html Drug Discovery Microsoft Office Microsoft Word Microsoft Excel Cellular Assays Molecular And Cellular Biology Bioethics Customer Service Catholic Theology Philosophy Video Games Teamwork Research Biochemistry Genetics Peptide Synthesis Spanish

Thomas Sawyer Education Details

  • University Of Massachusetts Amherst
    University Of Massachusetts Amherst
    Molecular And Cellular Biology
  • Ave Maria University
    Ave Maria University
    Theology/Theological Studies
  • Saint Michael'S College
    Saint Michael'S College
    Biochemistry And Philosophy

Frequently Asked Questions about Thomas Sawyer

What company does Thomas Sawyer work for?

Thomas Sawyer works for Peptide Drug Hunting Consortium

What is Thomas Sawyer's role at the current company?

Thomas Sawyer's current role is Managing Editor.

What is Thomas Sawyer's email address?

Thomas Sawyer's email address is tk****@****ass.edu

What is Thomas Sawyer's direct phone number?

Thomas Sawyer's direct phone number is +141351*****

What schools did Thomas Sawyer attend?

Thomas Sawyer attended University Of Massachusetts Amherst, Ave Maria University, Saint Michael's College.

What are some of Thomas Sawyer's interests?

Thomas Sawyer has interest in Kayaking, Trying New Cuisine, Horses, Reading, Shooting, Sports, Weight Lifting, Hockey, Watching Hockey, Watching Sports.

What skills is Thomas Sawyer known for?

Thomas Sawyer has skills like Philosophy Of Science, Writing, Powerpoint, Moral Psychology, Drug Design, Latin, Public Speaking, Cell Biology, Biology, Consumer Electronics, Chemistry, Teaching.

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