Tiago A. De Souza

Tiago A. De Souza Email and Phone Number

Bioinformatics Leader | Technical Innovator | Expert in NGS & Computational Biology | Mentor & Team Builder @ TauGC Bioinformatics
sao paulo, sao paulo, brazil
Tiago A. De Souza's Location
São Paulo, Brazil, Brazil
About Tiago A. De Souza

As a key skilled bioinformatician with over 15 years of experience in computational biology, genomics, NGS and molecular biology, I have served as an innovator to companies and research institutions during my career. My leadership extends across both scientific and non-scientific domains, encompassing responsibilities such as product development, and management of scientists, developers and IT professionals.I thrive in cross-functional teams, collaborating with computational and lab scientists to create, improve and validate products and novel approaches. As a skilled bioinformatician, I have proficiency in Python, Perl, R, cloud computing (GCP and AWS), statistical methods, R/Bioconductor, data visualization, workflow management (Snakemake), etc. I also kept my academic research production in a high-level, with + 40 papers published in high-impact journals. My expertise spans lab operations and bioinformatics, where I have successfully built and led bioinformatics teams in molecular diagnosis, computational omics, NGS data pipelines, cancer genomics, metagenomics, and so on. With a focus on fostering a culture of mutual respect, integrity, and collaboration, I am adept at setting clear objectives, providing constructive feedback, and facilitating the professional development of team members.Currently, I am directing my efforts in the private sector, focusing on science, innovation, and education in bioinformatics, computational genomics, and omics in general. I have a keen interest to create,maintain and improve tools to allow economic, enviromental and health impact to society.

Tiago A. De Souza's Current Company Details
TauGC Bioinformatics

Taugc Bioinformatics

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Bioinformatics Leader | Technical Innovator | Expert in NGS & Computational Biology | Mentor & Team Builder
sao paulo, sao paulo, brazil
Website:
taugc.com
Employees:
2
Tiago A. De Souza Work Experience Details
  • Taugc Bioinformatics
    Chief Technology Officer
    Taugc Bioinformatics Jan 2024 - Present
    São Paulo, Brazil
    Orchestrated scientific and technological initiatives while implementing innovative processes.• Led as scientific director, orchestrating scientific and technological initiatives while implementing innovative processes to more tan 40 outsourcing projects.• Established an exclusive cost-effective HPC virtual cluster, utilizing Snakemake, Docker, and Slurm. • Optimized NGS pipelines for faster and more reliable performance.• Constructed, validated, and deployed various data pipelines, including Polygenic Risk Score, 16S metagenomics, and transgenic detection (on-site/off-site).• Analyzed diverse datasets from RNA-Seq, exome, bacterial whole-genome sequencing, and germinative/somatic variant detection.• Conceived and developed three MVPs, including a metagenomics and a mutational signature diagnostic tool.
  • Taugc Bioinformatics
    Co-Chief Executive Officer
    Taugc Bioinformatics Oct 2023 - Dec 2023
    São Paulo, Brazil
  • Taugc Bioinformatics
    Chief Executive Officer
    Taugc Bioinformatics Dec 2019 - Sep 2023
    São Paulo, Brazil
    As the director and main partner at TauGC, orchestrated transformative initiatives, positioning the company at the forefront of both product development and education.• Successfully grew the team to 10 members (8 with a PhD degree), fostering diversity across biology and computer science backgrounds.• Achieved 7x increase in total revenue over three years, showcasing strategic business leadership.• Pioneered the conception and creation of a hybrid computational genomics course for 15 students, with a 50/50 gender composition.• Led the successful transition to cloud computing (78% carbon neutral - GCP), implementing cost-effective policies on preemtible VM use, disks, and storage buckets. Achieved a ~30% reduction in costs.• Introduced Agile methodologies in project management using Notion, resulting in reduced decision time, increased team interaction, and enhanced adherence to best practices.• Managed GitHub repositories and implemented automated quality assessments through GitHub Actions, ensuring code excellence.• Established and implemented robust team mentoring and performance evaluation processes, fostering a culture of continuous improvement.
  • Taugc Bioinformatics
    Senior Bioinformatics Scientist
    Taugc Bioinformatics Dec 2018 - Nov 2019
    São Paulo, Brazil
    Joined as a close collaborator to the original founder when TauGC was solely an outsourcing company serving universities. Contributed significantly to the successful delivery of over 10 projects, encompassing genomics, RNA-Seq, and 16S metagenomics, to customers in academia and various companies.
  • Bioinformatics Consultant
    Director Of Bioinformatics
    Bioinformatics Consultant Jan 2022 - Dec 2022
    São Paulo, Brazil
    Joined as the Director of Bioinformatics in a metabolomics startup post-venture capital investment, leading IT, data analysis, and roadmap strategies for key products: a human nutrition metabolomic test and a bovine fertility assessment test.• Team building and training: Contributed to team development, selection, training, and leadership of lab members.• Cross-functional team leadership: Reported to the CEO, managed the core IT and bioinformatics team using agile methodologies with Notion.• Product roadmap: Designed, gained approval, and executed duties associated with metabolomic products, collaborating with mass-spectrometry, scientific, nutritionist, veterinarian, and medical teams.• Data, IT, and Software development: Spearheaded data management plans, infrastructure, software development, good scientific practices, and documentation of protocols and processes.• Third-party contracts: Established and managed contracts and deals in IT and bioinformatics.• Metabolomics Web-platform: Developed a fully automated web-platform for a state-of-the-art nutrition metabolomic test, reducing time from data submission to results from hours to minutes.• Dynamic dashboards: Improved decision time using dynamic dashboards and implemented data policies.• Documentation and cloud storage: Documented all processes and protocols using Notion and cloud storage tools.• Machine learning: Coded and validated scripts for exploratory analysis of metabolomic data from bovine semen using machine learning approaches.• Prediction algorithms: Developed a reproducible machine learning algorithm predicting semen fertility with over 85% accuracy.
  • Bioinformatics Consultant
    Senior Scientist
    Bioinformatics Consultant Jan 2021 - Jan 2022
    São Paulo, Brazil
    Part-time senior scientist in a state-of-the-art andrology laboratory, managing research projects and implementing best practices in data usage and analysis.• Team building and training: Contributed to team development, involving selection, training, mentorship, and leadership of junior lab members and students.• Team leadership: Managed research projects, overseeing project design, execution, and collaboration with Scrum principles based on Notion.• Data Management Plan: Conceptualized and authored a data management plan for handling clinical data from patients.• Project review and analysis: Reviewed and provided feedback on projects, reports, and social media content from students.• Statistical and computational analysis: Led statistical and computational analysis of data from clinical research projects, designing and implementing dashboards for enhanced data visualization with based on R (Shiny)• Business Plan Design: Assisted in designing the business plan for molecular and pathological exams in clinical andrology diagnostics.
  • Universidade De São Paulo
    Research Fellowship
    Universidade De São Paulo Apr 2018 - Oct 2019
    São Paulo, Brazil
    I received a fellowship awarded by FAPESP for seniors IT/Bioinformatics professionals, focusing on the analysis and development of innovative approaches to dissect cancer mutational signatures and metagenomics.• Leadership in computational biology: Directed strategic initiatives in computational biology, providing pivotal support for IT infrastructure, and delivering comprehensive training for laboratory researchers and students.• Metagenomics project leadership: Pioneered the creation and execution (MVP) of a metagenomics project centered on Antarctic environmental samples. This initiative secured involvement in an international research alliance focused on DNA repair.• NGS pipeline development: Constructed a robust NGS pipeline utilizing Snakemake for the meticulous analysis of cancer sample mutational signatures. Conducted comprehensive training sessions for PhD students in this domain.• Data visualization: Revamped the visualization methods for intricate mutational data in cancer utilizing advanced R libraries, enhancing comprehension and insights for interdisciplinary researchers.• DMP implementation: Conception and implemented a comprehensive Data Management Plan (DMP) tailored for a research laboratory comprising approximately 20 members, spanning researchers, students, and professors.• High-impact publications: Collaborated with multidisciplinary teams, bridging researchers from diverse computational and non-computational backgrounds, resulting in the publication of 5 high-impact papers.
  • Universidade De São Paulo
    Doctoral Researcher
    Universidade De São Paulo Mar 2014 - Apr 2018
    São Paulo, Brazil
    Successfully obtained approval to do a Ph.D. in Biotechnology while maintaining full responsibilities and roles within the institution.• End-to-end NGS molecular diagnosis: Conducted DNA extraction, library prep, exome enrichment, Illumina sequencing, and data analysis including Sanger validation and functional experiments.• Led complex diagnosis of Mendelian diseases in mice using samtools, picard, gatk, expediting exclusive mutation identification akin to modern human WGS approaches.• Developed a Perl and R-based tool for mutational pattern analysis, later instrumental in skin cancer mutation assessments.• Directed cross-disciplinary teams of veterinarians and biologists, driving experimental decisions and explanations.• Identified strong candidate mutations in all mice via a single NGS sequencing effort, solving long-standing mouse model puzzles.• Characterized four novel mouse models for critical human diseases (audiogenic seizures, ataxia-like symptoms, psychomotor impairments, Kabuki syndrome) collaborating to four high-impact publications.• Established a mutation panel in Brazilian wild-type mice, widely utilized in diverse research.• Guided exploration of three distinct research themes across labs, fostering new investigations with students and post-docs.
  • Universidade De São Paulo
    Research And Development Specialist
    Universidade De São Paulo Jul 2011 - Mar 2017
    São Paulo, Brazil
    Contributed to start, establishing and maintaining a research multiuser facility. Engaged in all stages, from laboratory infrastructure construction to service logistics implementation. Leadership in sequencing hub, offering NGS services and bioinformatics support to universities, research institutes, and companies nationwide.• Lab management: Oversight of general management, financial administration, protocols, reagents, training, reports, and customer support within the facility.• NGS expertise: Development, validation, and execution of various NGS library protocols encompassing 16S and shotgun metagenomics, gene panels, exome, whole-genome, RNA-Seq, and gene-editing applications.• Team development and training: Played a key role in team building, including selection, training, mentorship, and leadership of junior lab technicians, bioinformaticians, and students.• Customer relationships: Provided advisory services to professors, researchers, and companies, offering experimental design guidance and assisting in data analysis.• Team building: Started as the first employee, managed solo in the initial year, and subsequently facilitated collaboration with over 10 individuals, encompassing biologists, bioinformaticians, and computer scientists in the NGS sequencing lab.• Growth of services: Transformed the facility from an idea with equipment boxes in corridors to four subfacilities (imaging, flow cytometry, NGS sequencing, mass spectrometry).• Impact of Research: More than 80 papers published by researchers which used services and/or equipaments provided by all facilities.• NGS as a service: Enabled customers by delivering validated lab pipelines, empowering them to focus on research, inquiries, and novel projects.
  • Centro Universitário Padre Anchieta
    Associate Professor
    Centro Universitário Padre Anchieta Mar 2010 - May 2014
    Jundiaí, São Paulo, Brazil
    Joined as a General Chemistry instructor for undergraduate Biological Sciences. students, delivering lectures and practical classes. Recognized for my performance, I received an invitation to additionally teach Biochemistry to students in Food Engineering and Environmental Management programs.
  • Brazilian Center For Research In Energy And Materials (Cnpem)
    Research Assistant
    Brazilian Center For Research In Energy And Materials (Cnpem) Jun 2010 - Jul 2011
    Campinas, São Paulo, Brazil
    Received a research assistant scholarship focusing on advancing studies in computational protein modeling, especially in scenarios lacking crystallographic structures.• In Silico NMR data analysis: Conducted comprehensive in-silico analysis of NMR data, employing bioinformatics tools for molecular modeling of proteins.• Script development: Created bash and Python scripts, enabling researchers and students without Linux expertise to perform molecular modeling of targets efficiently.• Training and protocol development: Offered training sessions and compiled protocols developed during the master's program for dissemination among lab members.• Documentation: Authored papers and reports detailing research findings and methodologies.
  • Brazilian Center For Research In Energy And Materials (Cnpem)
    Masters Student
    Brazilian Center For Research In Energy And Materials (Cnpem) Jan 2008 - Jun 2010
    Campinas, São Paulo, Brazil
    Focused on characterizing pivotal protein targets, serving as foundations for multiple student projects. Pioneered computational approaches in protein structure modeling and NMR data analysis.• Protein target characterization: Identified and validated plant protein targets as interactors of a bacterial disease effector from previous experiments.• Student training: Provided training to junior students in recombinant DNA technologies and supported lab members in cloning strategies and in-silico sequence analysis.• Protocol development: Innovated new lab protocols for DNA-protein interactions, cell-free protein-protein interactions, two-hybrid, EMSA, in-vitro protein-protein interaction, and advanced NMR techniques for studying protein dynamics.• Research publications: Authored two impactful papers and collaborated on a prestigious biochemistry journal, accumulating over 114 and 84 citations respectively.• Recognition and mentorship: Secured two best poster presentation prizes at international meetings and mentored a summer internship student who subsequently pursued a PhD in the lab.
  • Brazilian Center For Research In Energy And Materials (Cnpem)
    Research Internship
    Brazilian Center For Research In Energy And Materials (Cnpem) Aug 2006 - Jan 2008
    Campinas, São Paulo, Brazil
    Transitioning to a non-university research institution, I encountered a project-focused environment, developing my abilities to plan my activities with clear set of objectives and timelines. During this period, I improved my laboratory skills in molecular biology, specifically in cloning, expression, and protein purification.
  • State University Of Campinas
    Undergraduate Teaching Assistant
    State University Of Campinas Jul 2007 - Dec 2007
    Campinas, São Paulo, Brazil
    Assisted second-year students in the Biological Sciences program with classroom activities related to the discipline of Principles of Biochemistry.
  • State University Of Campinas
    Undergraduate Teaching Assistant
    State University Of Campinas Feb 2006 - Jul 2006
    Campinas, São Paulo, Brazil
    Assisted first-year students in the Biological Sciences program with classroom activities related to the discipline of Physiological and Molecular Genetics.
  • State University Of Campinas
    Research Internship
    State University Of Campinas May 2005 - Jul 2006
    Campinas, São Paulo, Brazil
    I conducted undergraduate research studying the biochemistry of the human pathogen responsible for Chagas disease, an often neglected illness prevalent in underdeveloped countries. This initial hands-on experience introduced me to molecular biology and instilled a sense of responsibility through collaborative research efforts within a team setting.

Tiago A. De Souza Skills

Pcr Biochemistry Molecular Biology Protein Expression Cell Culture Dna Sequencing Molecular Cloning Science Genetics Polymerase Chain Reaction Sequencing Bioinformatics Genomics Molecular Genetics R Perl Transcriptomics Metagenomics Ngs

Tiago A. De Souza Education Details

Frequently Asked Questions about Tiago A. De Souza

What company does Tiago A. De Souza work for?

Tiago A. De Souza works for Taugc Bioinformatics

What is Tiago A. De Souza's role at the current company?

Tiago A. De Souza's current role is Bioinformatics Leader | Technical Innovator | Expert in NGS & Computational Biology | Mentor & Team Builder.

What schools did Tiago A. De Souza attend?

Tiago A. De Souza attended Universidade De São Paulo, Universidade Estadual De Campinas, Universidade Estadual De Campinas, Universidade Estadual De Campinas, Universidade Federal De Viçosa.

What skills is Tiago A. De Souza known for?

Tiago A. De Souza has skills like Pcr, Biochemistry, Molecular Biology, Protein Expression, Cell Culture, Dna Sequencing, Molecular Cloning, Science, Genetics, Polymerase Chain Reaction, Sequencing, Bioinformatics.

Who are Tiago A. De Souza's colleagues?

Tiago A. De Souza's colleagues are Érica Rodrigues.

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