Team Leader - Enzyme Engineering
Current• Project lead from proof of concept to pre-commercialization of disruptive enzymatic RNA synthesis for customer-installed bench-top printer to make therapeutic RNA and Crispr guide RNA cheaper, faster, with higher purity and without sharing sensitive sequence data• Helped to secure high single-digit million dollar amount as part of DNA Script's Series B and C funding rounds in 2019 and 2021 by successfully realizing key milestones within the enzymatic RNA synthesis project• Achieved… Show more • Project lead from proof of concept to pre-commercialization of disruptive enzymatic RNA synthesis for customer-installed bench-top printer to make therapeutic RNA and Crispr guide RNA cheaper, faster, with higher purity and without sharing sensitive sequence data• Helped to secure high single-digit million dollar amount as part of DNA Script's Series B and C funding rounds in 2019 and 2021 by successfully realizing key milestones within the enzymatic RNA synthesis project• Achieved bench-top RNA synthesis of >60mers with purities comparable to commercial phosphoramidite-based RNA • Developed automated liquid handler-based enzymatic RNA synthesis process for therapeutic and Crispr guide RNA manufacturing including 2'-, base and phosphate modifications• Engineered proprietary RNA polymerases achieving commercial grade RNA purity by dramatically increasing polymerase activity, stability and production yield • Effectively managed project scale up including hiring of 8+ scientists/engineers and coordination between multidisciplinary R&D and cross-functional teams • Lead enzyme engineering projects for DNA synthesis, DNA cleavage and gene error correction Show less
