Tillmann Heinisch Email & Phone Number

Paris

• Project lead from proof of concept to pre-commercialization of disruptive enzymatic RNA synthesis for customer-installed bench-top printer to make therapeutic RNA and Crispr guide RNA cheaper, faster, with higher.
• Helped to secure high single-digit million dollar amount as part of DNA Script's Series B and C funding rounds in 2019 and 2021 by successfully realizing key milestones within the enzymatic RNA synthesis project
• Achieved… Show more
• Achieved bench-top RNA synthesis of >60mers with purities comparable to commercial phosphoramidite-based RNA
• Developed automated liquid handler-based enzymatic RNA synthesis process for therapeutic and Crispr guide RNA manufacturing including 2'-, base and phosphate modifications
• Engineered proprietary RNA polymerases achieving commercial grade RNA purity by dramatically increasing polymerase activity, stability and production yield

Development of E. coli surface display of streptavidin-biotin-catalysts to enable in vivo new-to-nature chemistries with use as biosensors and biofactories for pharma, fragrance and food production

Pasadena (USA)

3D structure determination, substrate profiling and high throughput assay development for the directed evolution of a novel indol nitrating cytochrome P450 enzyme TxtE

Basel (Schweiz)

Structure-based computational design and 3D structure determination of novel enantioselective imine reductase based on carbonic anhydrase-iridium complex

Biberach, Germany

Generation of large sets of small molecule solubility data for the development of a solubility prediction algorithm

Doctor Of Philosophy (Ph.D.), Chemistry And Protein Crystallography, (Magna Cum Laude)

Ph.D. with Prof. Thomas Ward (artificial metalloenzymes) and Prof. Tilman Schirmer (protein crystallography) Thesis title "Structure-Based.

Master Of Science (M.S.), Chemistry, (Mark: 1.3, Very Good)

Master’s thesis with Prof. Norbert Sträter (protein crystallographer), thesis title „Development of an artificial hydrogenase based on.

Bachelor Of Science (B.S.), Chemistry, (Mark: 1.7, Good)

I wrote a Bachelor’s thesis about the isolation and NMR-characterization of the natural products nicotine, theobromine, capsaicin and.

Education record