Tim Abram, Phd Email & Phone Number

New York, Us

• Managed and motivated a cross-functional team of scientists and engineers between Velox and UC Irvine to accomplish major milestones refining and expanding the capabilities of the Velox platform technology, resulting in 4 peer-reviewed publications• Established detailed study plans and led team to achieve 100% of success criteria from 2 technical due diligence evaluations from VC investors • Introduced new product concept based on quantitative market research surveys and interviews with KOLs to get VOC input, resulting in major pivot from company’s initial commercialization plan• Optimized optical instrumentation to achieve 50x improvement in diagnostic accuracy over leading competitor product for detecting rare cancer mutations in a pivotal head-to-head study• Evaluated business development/ strategic partnership opportunities through judicious planning and execution of feasibility studies to adapt 3rd party assay chemistry to Velox platform technology• Spearheaded clinical feasibility study and data analysis for antibiotic sensitivity testing prototype obtaining over 93% accuracy in 2 hours compared to gold standard test requiring 48-72 hours, representing a paradigm shift for antibiotic stewardship and same-day appropriate therapy

• Within first 2 weeks at Velox, increased sample throughput by over 8x by engineering a new microfluidic chip design, enabling the completion of a planned 45-day study in less than one week• Designed and optimized microfluidic consumables, thermocycler control hardware and software, and optical fluorescence detection instrumentation for Velox’s digital PCR molecular diagnostics platform• Developed microscopy image analysis automation scripts and GUIs in MATLAB and R to remove major bottlenecks, streamlining the assay development workflow from 6 hours to 15 minutes per experiment• Introduced quality control practices to company empowering team to identify sources of variation, leading to a 50% reduction in sample processing variability• Expanded capabilities of Velox core technology through innovative fluorescence lifetime analysis integration, increasing potential for assay multiplexing by 2-3x

• Designed and assembled prototypes for disposable assay cartridge compatible with both soluble analytes (for testing blood, saliva, urine, etc.) and cell-based assays (for digital pathology)• Managed the early phases of product development for innovative single-cell analysis technology for assessing oral cancer risk, creation of product requirements document, risk analysis/ FMEA • Decreased prototyping turnaround time from 3-4 weeks to < 1 day for plastic microfluidic cartridges by engineering high-precision CNC milling techniques with tolerances of less than 10 microns as an alternative to low volume injection molding• Introduced a vision system for detecting and artificially removing air-bubbles within assay cartridge, salvaging up to 20% of data per test which would otherwise have been lost• Led the development of a multi-wavelength, high resolution analyzer for point-of-care image cytometry through optical breadboard prototyping and verification studies

Houston, Tx, Us

• Curated the world’s largest single-cell database for oral premalignant lesions at over 13M profiled cells, and developed machine learning/ AI tools to extract meaningful insights for quantifying oral cancer risk• Directed the analysis and interpretation of cytology data from a 5-year clinical trial with over 700 patients in collaboration with clinical experts, resulting in 5 peer-reviewed publications (3 first-author)• Developed a groundbreaking risk scoring system to simplify the process of monitoring oral lesions which rivaled the diagnostic accuracy of expert pathologists in differentiating benign and cancerous lesions• Co-authored research and business plan for funded SBIR Phase I/II grant, earning PI $4M for technology commercialization of single-cell analysis platform for dental practitioners • Worked closely with a contract designer/manufacturer to transition a laboratory flow-cell to a form-factor injection-molded cartridge through iterative modeling, hands-on prototyping, and rigorous testing

San Luis Obispo, Ca, Us

• Developed new concept for flexible annuloplasty ring and deployment strategies to allow for future MIS procedures, resulting in an issued international patent for Edwards Lifesciences• Built finite element analysis models using COMSOL to simulate physiological loading conditions on new prototypes and verified similar function to traditional solid-core rings

San Luis Obispo, Ca, Us

Instructor – “BMED 111 – Biomedical Engineering Calculations”Developed lectures and course structure for core biomedical course with over 100 freshmen students, created and assigned homework assignments and midterm exams, held regular office hours to assist students; Maintained full teaching course-load while pursuing independent researchLab Instructor – “BMED 420 – Biomaterials” Developed lab experiments, advised students on class-based and independent research projects, maintained biomaterial testing equipment, delegated lab assistant responsibilities

San Luis Obispo, Ca, Us

Courses: Engineering Physiology, BioMEMS and Medical Microdevices, Biomedical Instrumentation, Engineering Physiology, Biomaterials, Biomedical Modeling/Computations, BiomechanicsCollaborated with instructors on student projects and assignments, led review sessions, graded homework assignments and exams, created laboratory projects, reviewed Problem-based-learning projects, and held regular student review sessions

Los Angeles, Ca, Us

Created data acquisition interface for testing bioMEMS devices using LabView; Developed and utilized testing platform for implantable strain sensor devices

Doctor Of Philosophy (Ph.D.), Bioengineering

Master’S Degree, Biomedical Engineering

Bachelor’S Degree, Biomedical Engineering