Medicinal/organic chemist with experience in multiple therapeutic areas, including antibacterials, antiparasitics, estrogen receptors, diabetes, obesity, hypertension, thrombosis and animal health. Led internal chemistry programs at Merck that discovered 6 preclinical candidates including 1 that is now an approved drug. Directed external chemistry teams of up to 25 chemists at two CROs. Key contributor to the discovery of several additional compounds of interest. Extensive knowledge of organic reaction mechanisms and structure determination techniques.Considerable experience reviewing grant applications for the National Institutes of Health and the Department of Defense. Proficient user of MS Office, Chemdraw, SciFinder, Chemcart, and ELN notebook software. PhD in organic chemistry from MIT. Extensive record of publications, presentations and patents.
Rna Focused Biotech Startup(Stealth Mode)
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Vice President - ChemistryRna Focused Biotech Startup(Stealth Mode) Nov 2022 - PresentPrinceton, NjLeading the company's medicinal chemistry programs to discover novel RNA-targeting small molecules. Responsible for new compound design, synthetic strategy, SAR development, and external chemistry (CRO) management. As a member of the company's leadership team, contribute to the development and execution of the company's overall R&D strategy.
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Senior Consultant And FounderXpharma Consulting Llc Jan 2014 - PresentPrinceton, NjConsultant and subject matter expert in medicinal and organic chemistry. Specializing in due diligence, review of medicinal chemistry programs and patent coverage, and synthetic route design and optimization. Expertise in multiple therapeutic areas including antibacterials, antiparasitics, estrogen receptors, diabetes, obesity, hypertension, thrombosis and animal health.Chemistry consultant for drug discovery companies, venture capital companies, and law firms.Winner of two Innocentive.com challenges: # 9933600 “A Scalable Cost and Atom Efficient Synthesis of a Benzothiazepine” and #9933733 “Design of a Self-Cleaving Linker For Targeted Drug Delivery”For additional information, see http://xpharmaconsulting.com
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Vice President, ChemistryExpansion Therapeutics Jan 2018 - Dec 2020Princeton, NjLed Expansion's medicinal chemistry programs to discover novel small molecule drugs for RNA-mediated diseases. Responsible for new compound design, synthetic strategy, and SAR development. Contributed to the development and execution of the company’s overall R&D strategy.
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Principal ScientistMerck Sep 1985 - Nov 2013Rahway, NjLed medicinal chemistry teams (up to 10 chemists) that discovered 6 pre-clinical candidates including Relebactam (MK-7655), the beta-lactamase inhibitor component of Recarbrio® which was approved by the FDA for use in treating certain resistant Gram-negative bacterial infectionsDirected the research effort of external medicinal chemistry teams (up to 25 chemists at two Asian CROs) on various discovery programsMember (for 3 years) of an internal scientific review committee that reviewed all process chemistry routes for the large-scale synthesis of development candidates and marketed productsKey individual contributor to the discovery of several additional compounds of interest -
Postdoctoral Research ScientistColumbia University Mar 1984 - Aug 1985NycResearch Advisor: Koji NakanishiPrepared steroids for studies on cholesterol metabolism in collaboration with Dr. Norman Javitt of NYUStudied preparation of photoaffinity-labelled brevetoxins to be used as probes of sodium channel structureInvestigated synthesis of steroidal marine natural products with shark repellent activityExperience in the isolation and purification of natural brevetoxins from cultures of P. Brevis
Tim Blizzard Education Details
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Organic Chemistry -
Chemistry
Frequently Asked Questions about Tim Blizzard
What company does Tim Blizzard work for?
Tim Blizzard works for Rna Focused Biotech Startup(Stealth Mode)
What is Tim Blizzard's role at the current company?
Tim Blizzard's current role is Vice President - Chemistry at a Biotech Startup (stealth mode).
What schools did Tim Blizzard attend?
Tim Blizzard attended Massachusetts Institute Of Technology, University Of Virginia.
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Tim Blizzard
Scottsboro, Al1htpg.com -
Tim Blizzard
United States
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