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Experienced Research Scientist with a demonstrated history of research and teaching in higher education. Skilled in Electrophysiology, Data Analysis, Animal Models, Virally Mediated Gene Transfer technology, Recombinant DNA technology, in situ hybridization, Confocal Microscopy. Strong research professional with a Ph.D. focused in Neuroscience from University of Washington.
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Scientist IiOmeros Corporation Mar 2022 - PresentSeattle, Wa, UsImmuno-oncology therapeutic development and in vivo cancer models. In vivo models of drug addiction and treatment: animal surgery, self-administration and reinstatement. -
Scientist IOmeros Corporation Mar 2018 - Mar 2022Seattle, Wa, UsDevelopment and implementation of discovery models of drug action for drug pipeline evaluation. Animal models of drug addiction and treatment: animal surgery, self-administration and reinstatement.
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Research ScientistUniversity Of Washington Oct 2016 - Dec 2017Seattle, Wa, UsDepartment of OphthalmologyPrincipal Investigator: Russell N. Van Gelder, MD, PhDIn collaboration with the biotechnology company OmerosDrug development targeting melanopsin, a GPCR photopigment in the mammalian retina. Includes ex vivo electrophysiological testing of high-throughput screening hits on retinal preps and in vivo testing of final candidates. Candidate molecules screened by Omeros. -
Instructor, BiologyEdmonds Community College Jan 2016 - Dec 2016Lynnwood, Wa, UsSurvey of Biology, Lecture and Lab (Winter, Summer, Fall)Introductory, undergraduate, non-major’s class for 15 to 40 students. Topics: ecology, human physiology, genetics and biotechnology, cancer, and evolution.Cellular Biology Lab (Winter)Undergraduate major’s cellular biology lab section covering microscopy, cell structure, energetics, enzymology, photosynthesis, and DNA and biotechnology. -
Lecturer, Uw Honors ProgramUniversity Of Washington Sep 2015 - Dec 2015Seattle, Wa, UsThe Neuroscience of Sex (Fall)Undergraduate, non-major’s neuroscience seminar on the neurobiology of reproduction, sex, gender, sexual orientation, and love. Student centered learning of primary scientific literature in context of the science and societal implications. Strong emphasis on writing and presentations.
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Senior Postdoctoral FellowUniversity Of Washington Dec 2013 - Dec 2014Seattle, Wa, UsDepartment of OphthalmologyPrincipal Investigator: Russell N. Van Gelder, MD, PhDIntrinsically photosensitive retinal ganglion cells (ipRGCs), a third photoreceptor in the mammalian retina, subserve non-visual photoreception functions such as circadian entrainment and the pupillary light response. Project 1: Determined that changes in ipRGC light responses during development accompanied by a dramatic decrease in levels of the photopigment melanopsin in the different ipRGC subtypes. Project 2: Screened set of small molecule melanopsin agonist candidates on ipRGC activity in ex vivo retinal preps using multi-electrode array. Candidate drugs identified by high throughput screening by Roche Pharmaceuticals,
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Graduate StudentUniversity Of Washington Oct 2007 - Dec 2013Seattle, Wa, UsGraduate Program in Neuroscience (previously Neurobiology and Behavior) Advisor: Russell N. Van Gelder, MD, PhDDissertation: Physiology and Development of Inner Retinal Photoreception.Melanopsin is the GPCR photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs), a third photoreceptor type in the mammalian retina. Project 1: Determined in vivo chromophore preference for melanopsin, supporting a bistable mechanism of chromophore recycling for melanopsin. Project 2: Characterized changes in early post-natal development of ipRGC light responses and firing characteristics. Project 3: Demonstrated that G-protein regulating kinase 2 (GRK-2) only minimally regulates melanopsin despite previous evidence implicating it in melanopsin phosphorylation and signal termination.
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InstructorUniversity Of Washington Oct 2012 - Dec 2012Seattle, Wa, UsUniversity of Washington, 2012Instructor, Neurobiology (Fall) Undergraduate Neurobiology SeminarDeveloped curriculum for and led seminar on sleep and sleep physiology. Included short lectures followed by student discussion and presentation of primary literatureSupervising faculty: William Moody, PhD, Horacio de la Iglesia, PhD
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Supplemental Chorus MemberSeattle Opera 2005 - 2010Seattle, Wa, UsGotterdamerung (two productions)AidaFlying Dutchman -
Research Scientist, Laboratory ManagerUniversity Of Washington Oct 1994 - Aug 2007Seattle, Wa, UsDepartment of Psychiatry and Behavioral SciencePrincipal Investigator and Supervisor: John F. Neumaier, MD, PhD.Role of serotonin receptors in animal models of stress, depression, schizophrenia and drug addiction. Lead technician and laboratory manager. Lab management included compliance with university, state and federal regulations concerning hazardous materials, radioactive materials and controlled substances (schedule I drugs). Involved in, or responsible for hiring and supervising laboratory personnel. A sample of major projects I led include: Project 1: Demonstrated altered serotonin receptor 5-HT1B activity in striatum following long-term treatment with the street drug methylenedioxymethamphetamine (MDMA). First author paper published.Project 2: Established production of a Herpes Simplex Virus (HSV) based virally mediated gene transfer system, including designing and building viral constructs and the production of high titer virus for injection into rat brain. Project 3: Developed serotonin promoter specific HSV construct and virus as lab’s first promoter specific virus.
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Summer Research AssistantVollum Institute For Biomedical Research Jun 1994 - Aug 1994Principal Investigator: Gary Thomas, PhDSubtylisin-like endoprotease furin processing of pre-proopiomelanocortin in vitro.
Timothy Sexton Skills
Timothy Sexton Education Details
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University Of WashingtonNeuroscience -
Reed CollegeBiology
Frequently Asked Questions about Timothy Sexton
What company does Timothy Sexton work for?
Timothy Sexton works for Omeros Corporation
What is Timothy Sexton's role at the current company?
Timothy Sexton's current role is Scientist II at Omeros Corporation.
What is Timothy Sexton's email address?
Timothy Sexton's email address is ts****@****ton.edu
What is Timothy Sexton's direct phone number?
Timothy Sexton's direct phone number is +120634*****
What schools did Timothy Sexton attend?
Timothy Sexton attended University Of Washington, Reed College.
What are some of Timothy Sexton's interests?
Timothy Sexton has interest in Music, Art, Science, Health.
What skills is Timothy Sexton known for?
Timothy Sexton has skills like Molecular Biology, Neuroscience, Immunohistochemistry, Confocal Microscopy, Cell Culture, Scientific Writing, Pcr, Cell Biology, Fluorescence Microscopy, Biochemistry, Data Analysis, Genetics.
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