Todd Bowser's Location
Greater Boston, United States, United States
Todd Bowser's Contact Details
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About Todd Bowser
R&D program and alliance leader with >20 years of biopharmaceutical and non-profit experience in the discovery and development of novel therapeutic agents. Therapeutic areas include oncology, infectious disease, neurodegeneration, and inflammation. Experience building and leading successful cross-functional R&D teams in a global setting. PhD Medicinal Chemist by training with strong scientific background.
Todd Bowser Work Experience Details
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Vice President Of Program Management And R&D Strategic OperationsNimbus Therapeutics Oct 2024 - PresentBoston, Massachusetts, Us -
Program Management LeaderBill & Melinda Gates Medical Research Institute Aug 2022 - Oct 2024Cambridge, Ma, UsBiologic and vaccine development for Global Health -
Vice President Of Portfolio And Program LeadershipMersana Therapeutics Sep 2021 - Jun 2022Cambridge, Ma, UsNovel ADC therapeutic development -
Program LeadBill & Melinda Gates Medical Research Institute Sep 2019 - Sep 2021Cambridge, Ma, UsProgram lead for tuberculosis drug development
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Senior Director, R&D Project LeadershipCyteir Therapeutics Aug 2018 - Aug 2019Lexington, Ma, Us -
Executive Director Of Program ManagementH3 Biomedicine Feb 2017 - Aug 2018Head of Program Management for oncology R&D
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Director Of Program ManagementH3 Biomedicine Dec 2015 - Jan 2017Program manager for oncology drug research and development.
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Associate Director, Program ManagementH3 Biomedicine Apr 2014 - Dec 2015Program manager for oncology drug discovery and development.
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Associate Director Of Project And Business Alliance ManagementParatek Pharmaceuticals, Inc. 2010 - Apr 2014Boston, Ma, UsManagement of discovery, development and partnering of novel tetracyclines for the treatment of neurodegenerative, inflammatory, ischemic and infective diseases including orphan indications. Therapeutic areas include Spinal Muscular Atrophy, Acne, Multiple Sclerosis, Fragile X, Arthritis and Animal Health. • Alliance manager for clinical Acne product WC3035 currently in Phase II. Duties include managing relationship with development partner Warner Chilcott, serving on joint steering committee and communicating project status to upper management. Managed internal resources and CROs to carry out pre-IND studies and contributed to preparation of successful IND application.• Internal project manager for the clinical development of a novel tetracycline for the treatment of respiratory infections in domestic animals. Point of contact for confidential development partner and member of joint project team. Managed internal and external resources to support development. Initiated new business development opportunities with development partner for additional products. • Project leader for pre-clinical development projects in Spinal Muscular Atrophy, Multiple Sclerosis, Fragile X, Arthritis and animal health. Managed CRO and internal studies to support development, identified new business development opportunities, engaged in successful partnering discussions as lead product representative, established relationships with key opinion leaders, established new academic and consultant relationships and prepared successful grant applications to support development activities. Served as company representative at family advocacy group meeting for Spinal Muscular Atrophy patients (publicly presented project and answered questions from patients and family members). Prepared pre-IND package and led successful pre-IND meeting with the FDA for orphan disease indication (SMA). -
Group Leader For Neurodegenerative And Anti-Inflammatory Drug DiscoveryParatek Pharmaceuticals, Inc. 2004 - 2010Boston, Ma, Us• Led medicinal chemistry team in the discovery and optimization of novel semi-synthetic tetracycline derivatives as lead compounds for anti-inflammatory and neurodegenerative diseases.• Served as a member of the core management team responsible for the discovery of non-antibacterial tetracyclines for the oral treatment of Multiple Sclerosis. Efforts lead to the successful delivery of a pre-clinical candidate for Multiple Sclerosis (collaboration with MerckSerono) which is currently completing pre-IND studies.• Served on core management team responsible for the discovery and evaluation of a small molecule treatment for Spinal Muscular Atrophy (collaboration with the FSMA foundation). Efforts led to the successful funding of a U01 NIH-funded grant for clinical development of these agents.• Developed novel enzyme and antioxidant assays to support optimization of lead compounds.• Supervised a medicinal chemistry group (3 PhD scientists, 1 associate)
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Senior Scientist And Project Coordinator For Anti-Infective Drug DiscoveryParatek Pharmaceuticals, Inc. 2002 - 2004Boston, Ma, Us• Led the design, synthesis and optimization of tetracycline prodrugs for the oral treatment of Gram positive infections. Developed biochemical assays to predict rate of prodrug hydrolysis in biological samples.• Collaborated with Microbiology, Pharmacology and Toxicology groups as a member of the core management team to identify orally-efficacious tetracyclines for community-acquired infections. Efforts led to the identification of lead compounds under evaluation for clinical development.• Managed the discovery, design, synthesis and optimization of novel benzimidazole inhibitors of Multiple Antibiotic Resistance (MAR) bacterial virulence factors. Identified hit compounds using structure-based drug design and optimized hits to nanomolar inhibitors of MAR proteins.• Served on the core management team to identify novel MAR inhibitors for the treatment of Urinary Tract Infections. Efforts led to the discovery of several efficacious compounds for the treatment of E. coli infections. The results of this effort led to the successful funding of an SBIR grant application.• Supervised a medicinal chemistry group (3 PhD scientists).
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Scientist IiParatek Pharmaceuticals, Inc. 1999 - 2002Boston, Ma, Us• Designed and synthesized novel tetracycline derivatives with potent in vitro activity against antibiotic-resistant organisms. • Utilized rational drug design to optimize in vitro and in vivo properties of initial hit compounds.• Developed HPLC and SPE methodology for the purification of discovery compounds as pure epimers.• Contributed significantly to the discovery and development of PTK0796 which has successfully completed Phase II clinical trials and has entered Phase III trials.• Supervised an associate chemist.
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Nih Post-Doctoral Research FellowBrown University 1997 - 1999Providence, Rhode Island, UsNIH post-doctoral fellow in the laboratory of Prof. David E. Cane studying the biosynthesis of sesquiterpene natural products. Designed and synthesized mechanism-based inactivators of tricodiene synthase.
Todd Bowser Skills
Drug Discovery
Clinical Development
Drug Development
Biotechnology
Pharmaceutical Industry
Assay Development
Ind
In Vitro
Pharmacokinetics
In Vivo
Life Sciences
Cro
Medicinal Chemistry
Hplc
Biomarker Discovery
Pharmacology
Lifesciences
Bioanalysis
Clinical Trials
Analytical Chemistry
Gmp
Molecular Biology
Chemistry
Sop
Oncology
Biochemistry
Elisa
Fda
R&d
Drug Design
Infectious Diseases
Todd Bowser Education Details
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Baylor UniversityMechanistic Enzymology -
Franklin & Marshall CollegeBiology
Frequently Asked Questions about Todd Bowser
What company does Todd Bowser work for?
Todd Bowser works for Nimbus Therapeutics
What is Todd Bowser's role at the current company?
Todd Bowser's current role is Biopharmaceutical R&D Program Leader.
What is Todd Bowser's email address?
Todd Bowser's email address is tb****@****arm.com
What is Todd Bowser's direct phone number?
Todd Bowser's direct phone number is +161725*****
What schools did Todd Bowser attend?
Todd Bowser attended Baylor University, Franklin & Marshall College.
What skills is Todd Bowser known for?
Todd Bowser has skills like Drug Discovery, Clinical Development, Drug Development, Biotechnology, Pharmaceutical Industry, Assay Development, Ind, In Vitro, Pharmacokinetics, In Vivo, Life Sciences, Cro.
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