Todd Seeley Email & Phone Number

San Francisco, Ca, Us

R&D target discovery and validation, expression development, research protein expression and purification. Affymetrix microarray technology, RNAseq, HTS QPCR expression profiling, bioinformatics. Patient indication selection, pharmacogenomics, toxicogenomics. Mechanism of action of novel small molecule and antibody therapeutics. CHO production cell line for therapeutic mAb. Preclinical oncology tumor models. Cell and Molecular Biology, Protein Chemistry. Strategic planning, coordination of external collaborators/contractors, preparation and review of technical proposals, budgets, acquisition of essential equipment and materials. Regulatory documentation, including participation in multiple IND filings. Intellectual property review and support.

Emeryville, California, Us

Cancer targets and mechanisms, Rusty Williams lab. Novel human cDNAs, tumor suppressor genes and gene products (three patents); RACE, cDNA cloning, RT-PCR, Northern analysis, and Q-PCR. Chromosomal localization by Radiation Hybrid (RH) mapping. Target validation, antisense cDNA and oligonucleotide mRNA ablation. Expressed novel proteins in bacteria and insect cells, purified proteins via affinity tags and classical techniques. Primary and secondary screens for small molecule inhibitors; kinase inhibition, substrate specificity, cell cycle, apoptosis, transcription, cell viability assays. Microbial Expression group, Michael Innis lab. Optimized expression of therapeutic proteins in bacteria, yeast; including IGF-1, PDGF, TFPI, b-interferon. Classical genetic and molecular screens for improved strain production. First in-house use of Q-PCR technology. Optimized gene therapy vector for HSV-TK expression in cancer, GCV killing assays. Patents, declarations filed.

Seattle, Wa, Us

Post-Doctoral Fellow, Leland Hartwell lab. Role of cell cycle regulation in response to DNA damage in S. cerevisiae. Novel genetic screens to identify genes involved in cell cycle response to DNA damage. Functional analyses of yeast genes, including classical epistasis testing, functional models for pathway characterization. Leland Hartwell was awarded the Nobel Prize in Medicine in 2001.

Ph.D., Biochemistry And Molecular Biology

B.S., Genetics