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- Well-versed in integrating both small molecules and antibody screening data with baseline profiles of the cell lines and animal studies. Worked with >18 different projects in multiple pharma and biotech settings- >5 years experiences as program team lead (PTL) and led an interdisciplinary team of biologists and chemists on pre-clinical small molecules, degraders, and biologics drug development, with hands-on experience from target identification to IND-enabling studies- Aligned project plans, milestones, priorities and develop mitigation strategies to meet corporate program objectives and build effective communication with executive leadership team and/or BoD- Hired and coached multiple PhD scientists (both senior and junior level), research associate and intern to form a highly motivated and productive team in both small molecules and antibody R&D settings- Expertise in bioassay development, molecular cell biology, DNA damage response, cancer cell signaling, transcriptional regulatory network, vascular biology and matrix biology that have led to several government research funding and high impact scientific publications, including Cell, Journal of Cell Biology and EBioMed- Wrote patents, IND report, reviews, manuscripts, grants, and fellowships
Athae Bio
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Senior Director Of BiologyAthae BioBoston, Ma, Us
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Senior Director, Head Of BiologyCold Start Therapeutics (Formerly Athae Bio) Oct 2023 - Present
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Director BiologyCivetta Therapeutics Jan 2023 - Aug 2023Cambridge, Massachusetts, Us -
Associate Director Of BiologyCivetta Therapeutics Mar 2022 - Jan 2023Cambridge, Massachusetts, Us
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Principal ScientistKronos Bio, Inc. Jan 2021 - Mar 2022San Mateo, California, Us -
Senior Scientist, BiologyKronos Bio, Inc. Oct 2019 - Jan 2021San Mateo, California, Us
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Staff ScientistRegeneron Pharmaceuticals, Inc. Jan 2019 - Oct 2019Tarrytown, New York, Us -
ScientistRegeneron Pharmaceuticals, Inc. Jul 2015 - Dec 2018Tarrytown, New York, Us
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Postdoctoral Research FellowGenentech Jul 2010 - Jul 2015South San Francisco, California, Us• Spearheaded an original and innovative research project, from its initiation, to uncover unique cross-regulation between MET and VEGFR2 with potentially important combination therapeutic implications in solid tumors• Discovered and depicted a novel mechanism of MET-induced IRE1α-mediated ER-associated VEGFR2 degradation via intracrine VEGF, which is the first solid evidence of growth factor-induced ER stress response been identified up to date• Identified VEGFR1 as the driver for VEGF-independent tumor formation both in PyMT-driven mammary tumorigenesis and in vitro for tumor cell migration• Mobilized and coordinated support within the Genentech community, including CALM, AAT, FACS, Bioinformatics, compound management, animal model facilities, mouse genetics department, pathology department and angiogenesis group -
Postdoc FellowUcla Jan 2010 - Jun 2010Los Angeles, Ca, UsInvestigated binding of VEGF to an array of matrix proteins in vivo and its biological significance -
Vascular Biology Graduate TraineeUcla Sep 2004 - Jun 2009Los Angeles, Ca, Us• Identified matrix-bound VEGF conveys differential signaling responses to endothelial cells in contrast to soluble VEGF• Elucidated VEGFR2 internalization and VEGF intracrine signaling on vascular homeostasis as the first solid evidence of intracellular VEGF signaling • Performed mass-spec and antibody array to determine the phospho-tyrosine pattern on VEGFR2 and recruitment of its secondary messengers • Published a first-author research article in J. Cell Biol. (≥ 120 citations since 2010) and a second-author research article in Cell (≥ 540 citations since 2007)
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Teaching AssistantUcla Sep 2004 - Dec 2005Los Angeles, Ca, Us Teaching assistant of the course "LS4: Genetics" in life science department. Teaching assistant of the course “MCDB165A: Molecular Cell Biology” in MCDB department
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Research AssistantUcsf Medical Center Sep 2001 - Jul 2003San Francisco, Ca, Us Gene regulation of CAPSAICIN receptor (TRPV1) transcription Expression cloning of novel pain-related mechano-receptor Co-authored in a research article in J. Neurochemistry. -
Part-Time Research AssistantUsda Aug 2001 - Jul 2003Washington, Dc, Us• Investigated the effects of natural compound inhibitory to fungal growth and aflatoxin biosynthesis
Tom Chen Skills
Tom Chen Education Details
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UclaMolecular Cell And Developmental Biology -
University Of California, BerkeleyMolecular Cell Biology
Frequently Asked Questions about Tom Chen
What company does Tom Chen work for?
Tom Chen works for Athae Bio
What is Tom Chen's role at the current company?
Tom Chen's current role is Senior Director of Biology.
What is Tom Chen's email address?
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What is Tom Chen's direct phone number?
Tom Chen's direct phone number is +151037*****
What schools did Tom Chen attend?
Tom Chen attended Ucla, University Of California, Berkeley.
What are some of Tom Chen's interests?
Tom Chen has interest in Skiing, Snowboarding, Basketball, Reading, Hiking, Pingpong, Squash, Tennis, Movies.
What skills is Tom Chen known for?
Tom Chen has skills like Molecular Biology, Cell Culture, Cell, Biochemistry, Assay Development, Cell Biology, Protein Chemistry, Elisa, Cancer Research, Microscopy, Confocal Microscopy, Western Blotting.
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