Associate Professor
Current
Feb 2016 - Present
AeroLeads people directory · profile
Tom Cunningham Email & Phone Number
Associate Professor
at
University of Cincinnati
1 work email found
@uc.edu
LinkedIn matched
✓ Verified May 2026
4 data sources
Profile completeness 100%
Current company
Role
Associate Professor
Location
Cincinnati, Ohio, United States
Company size
Who is Tom Cunningham? Overview
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Quick answer
Tom Cunningham is listed as Associate Professor at University of Cincinnati, a company with 16691 employees, based in Cincinnati, Ohio, United States. AeroLeads shows a work email signal at uc.edu and a matched LinkedIn profile for Tom Cunningham.
Tom Cunningham previously worked as Postdoctoral Fellow at Ucsf and Graduate Student at Harvard Medical School. Tom Cunningham holds Doctor Of Philosophy - Phd, Biochemistry, Cell And Molecular Biology from The Johns Hopkins University School Of Medicine.
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{first}.{last}@uc.edu
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Profile bio
About Tom Cunningham
The overall focus of my research centers on understanding the mechanistic basis for the reprogramming of cellular metabolism upon activation of oncogenic pathways. Cancer cells display alterations in the uptake and utilization of nutrients that distinguish them from normal cells. The identification of these key differences may pinpoint vulnerabilities in cancer cells and provide a path for novel therapeutic intervention. The question then becomes, “How can we identify these key differences in the metabolism of normal cells versus cancer cells?” My research involves a multifaceted approach that utilizes the disciplines and tools of biochemistry, molecular biology, mouse genetics, metabolomics, and cell biology to elucidate the molecular underpinnings of disease etiology. I believe we can use the knowledge of signaling pathways and cellular processes known to be perturbed in cancer cells to discover distinct points of intersection with the metabolic network. For example, my PhD work utilized a computational genomics approach to identify a novel connection between the mTOR signaling pathway and the transcriptional machinery responsible for controlling the expression of mitochondrial genes important for cellular energy production. During my postdoctoral training, I found a functional link between the protein synthesis capacity of MYC-overexpressing cells and the nucleotide biosynthesis pathway. Importantly, loss of function of the key enzyme at the nexus of protein synthesis and nucleotide metabolism specifically kills cancer cells but not normal cells, therefore suggesting new therapeutics capable of targeting this key metabolic node may be powerful anti-cancer treatments. The ultimate goal of my research is to translate the basic science of the continued identification of these critical metabolic nodes into new drugs, diagnostic tools, and biological insights that can positively impact patient health and survival.
Listed skills include Molecular Cloning, Qpcr, Molecular Biology, Western Blotting, and 46 others.
Current workplace
Tom Cunningham's current company
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University Of Cincinnati
4 roles
Tom Cunningham work experience
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Postdoctoral Fellow
- Regulation of cellular metabolism and cancer development by Myc-dependent translational control
- Discovered a novel connection between the cellular rates of protein synthesis and nucleotide production downstream of Myc hyperactivation
- Identified PRPS2, a rate-limiting enzyme of nucleotide synthesis, as a key mediator of Myc-driven tumorigenesis
- Established the relevance of Myc-dependent increases in protein synthesis in stimulating the Unfolded Protein Response as a mechanism to promote cancer development
- Developed a Cre-activateable Myc transgenic mouse that, when activated, simultaneously ‘tags’ Myc-overexpressing cells with a fluorescent reporter protein (unpublished)
Sep 2009 - Feb 2016
Graduate Student
- Mechanistic basis of mTOR-dependent transcriptional control of cellular metabolism
- Identified the YY1 transcription factor as the key mediator of the mTOR-dependent transcriptional program
- Elucidated the mechanistic basis by which mTOR signalling controls PGC-1α-regulated mitochondrial gene expression
- Discovered a role for YY1 in regulating insulin/IGF signaling pathway genes via recruitment of the polycomb co-repressor, Pc2
Nov 2006 - Aug 2009
Graduate Student
- Mechanistic basis of mTOR-dependent transcriptional control of cellular metabolism
- Identified the YY1 transcription factor as the key mediator of the mTOR-dependent transcriptional program
- Elucidated the mechanistic basis by which mTOR signalling controls PGC-1α-regulated mitochondrial gene expression
- Discovered a role for YY1 in regulating insulin/IGF signaling pathway genes via recruitment of the polycomb co-repressor, Pc2
Sep 2002 - Nov 2006
5 education records
Tom Cunningham education
Doctor Of Philosophy - Phd, Biochemistry, Cell And Molecular Biology
Phd, Biochemistry, Cell And Molecular Biology
Bachelor'S Degree
Bachelor'S Degree, Recombinant Gene Technology & Chemistry
Bachelor Of Science (Bs), Recombinant Gene Technology And Chemistry, Summa Cum Laude
FAQ
Frequently asked questions about Tom Cunningham
Quick answers generated from the profile data available on this page.
What company does Tom Cunningham work for?
Tom Cunningham works for University of Cincinnati.
What is Tom Cunningham's role at University of Cincinnati?
Tom Cunningham is listed as Associate Professor at University of Cincinnati.
What is Tom Cunningham's email address?
AeroLeads has found 1 work email signal at @uc.edu for Tom Cunningham at University of Cincinnati.
Where is Tom Cunningham based?
Tom Cunningham is based in Cincinnati, Ohio, United States while working with University of Cincinnati.
What companies has Tom Cunningham worked for?
Tom Cunningham has worked for University Of Cincinnati, Ucsf, Harvard Medical School, and Johns Hopkins School Of Medicine.
How can I contact Tom Cunningham?
You can use AeroLeads to view verified contact signals for Tom Cunningham at University of Cincinnati, including work email, phone, and LinkedIn data when available.
What schools did Tom Cunningham attend?
Tom Cunningham holds Doctor Of Philosophy - Phd, Biochemistry, Cell And Molecular Biology from The Johns Hopkins University School Of Medicine.
What skills is Tom Cunningham known for?
Tom Cunningham is listed with skills including Molecular Cloning, Qpcr, Molecular Biology, Western Blotting, Cell Biology, Protein Expression, Tissue Culture, and Cancer Research.
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