Travis Rush Email & Phone Number

Upper Providence, Pennsylvania, United States

Salt Lake City, Utah, Us

Salt Lake City, Utah, Us

Partnering with Senior Leadership to define two delivery anchors spanning multiple departments and cross-functional groups.Leading and Growing a multi-level team to near >15 neuroscientists across four delivery areas.Defining cross-functional strategy and multi-year build of Recursion's Neuroscience Platform.Partnering closely with Senior Leadership / Execs, I'm working to coordinate several departments' efforts to successfully onboard neural cell types to generate Recursion's Map of Human Neurobiology. Recursion's mission is to use maps such as this to Decode Biology and Radically Improve Lives of patients, by expediting Drug Discovery.

Salt Lake City, Utah, Us

Built a functional group, expanding multi-level team from 3 to 9 in less than 3 months..Effective manager and mentor from onboarding new personnel through successful coaching into Bio Leadership roles.Partnered with Director and other Senior Scientist Group Leads to define a new department and plans for the next ~2 year horizon. Strategic Scientific lead helping Executives define Recursion's Neuroscience platform build.Scientific Team Lead and Biology Lead across several prominent programs within Recursion's Pipeline.Effective leader of cross-functional project teams driving drug discovery decisions by coordinating the activities of research staff (direct reports), and teammates from Chemistry, Commercial, Development, In Vivo (PK, ADMET, efficacy studies), and Toxicology departments.

Salt Lake City, Utah, Us

Demonstrated impact on Recursion's drug-discovery portfolio through decision-informing data generation. Cross-functional project leadership. Expanded mentorship role as we built the neuroscience stronghold and hired several Research Scientists and Associates

Salt Lake City, Utah, Us

Birmingham, Al, Us

Hit-to-lead optimization for a drug discovery program targeting neurodegeneration in Alzheimer's disease. Our target: a novel interaction between the microtubule associated protein, tau, and a kinase important to the synaptic loss underlying disease disease. Studies involved high-content, automated imaging of primary rodent neurons, proximity ligation, immunofluorescence, and routine molecular biology and biochemistry assays. Publications:Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ, McMahon LL, and Roberson ED. Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. (2020) eLife Jul 13;9:e57354Rush T*, Roth JR*, Thompson SJ, Aldaher AR, Cochran JN, and Roberson ED. (2020) A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiol Dis. 134:104668.Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, and Herskowitz JH. (2016) ROCK1 is increased in Alzheimer’s disease and ROCK1 depletion reduces amyloid-β levels in brain. J Neurochem, 138(4):525-31.Cochran JN, Rush T, Buckingham SC, Roberson ED. (2015) The Alzheimer’s disease risk factor CD2AP maintains blood-brain barrier integrity. Hum Mol Genet, 24(23):6667-74.

Paris, 13, Fr

Preclinical, in vitro experimentationLive-neuron imaging, biochemistry and molecular biology.Statistical analysis and conclusive interpretation of results. Results dissemination via internationally recognized journals and conferences.Grant preparation, writing and submission.Publications:Rush T*, Martinez-Hernandez J*, Dollmeyer M*, Frandemiche ML, Borel E, Boisseau S, Jacquier-Sarlin M, and Buisson A. (2018) Aβ oligomers induce synaptic impairment by acutely stabilizing the actin cytoskeleton through cofilin phosphorylation. J Neurosci, 38(48):10349-61. Amar F, Sherman MA, Rush T, Larson M, Boyle G, Chang L, Gotz J, Ashe KH, Buisson A, and Lesne SE. (2017) Specific alterations of tau phosphorylation and neuronal signaling induced by the amyloid-β oligomer Aβ*56. Sci Signal, 10(478).Travis Rush*, Alain Buisson. Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral. Cell Tissue Res. 2014, 356(2), 279-86. Review.Marie Lise Frandemiche, Sandrine De Seranno, Travis Rush*, Eve Borel, Auréliane Elie, Isabelle Arnal, Fabien Lanté, Alain Buisson. Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers. J Neurosci. 2014, 34(17), 6084-97.Javier Becerril-Ortega, Karim Bordji, Thomas Fréret, Travis Rush*, Alain Buisson. Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease. Neurobiol Aging. 2014, 35(10), 2288-301.

Milwaukee, Wi, Us

Travis Rush*, XiaoQian Liu, Andrew B. Nowakowski, David H. Petering and Doug Lobner. Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1. Neurotoxicology. 2012 Jun;33(3):476-81.Travis Rush*, XiaoQian Liu and Doug Lobner. Synergistic toxicity of the environmental neurotoxins methylmercury and β-N-methylamino-L-alanine. Neuroreport. 2012 Mar 7;23(4):216-9.XiaoQian Liu, Jon Resch, Travis Rush* and Doug Lobner. Functional upregulation of system xc- by fibroblast growth factor-2. Neuropharmacology. 2012 Feb;62(2):901-6.Travis Rush*, XiaoQian Liu, Julie Hjelmhaug and Doug Lobner. Mechanisms of chorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. 2010 Mar 31;166(3):899-906.XiaoQian Liu, Travis Rush*, Jennifer Ciske and Doug Lobner. Selective death of cholinergic neurons induced by β-N-methylamino-L-alanine. Neuroreport. 2010 Jan 6;21(1):55-8.XiaoQian Liu, Travis Rush*, Jasmine Zapata and Doug Lobner. β-N-methylamino-L-alanine induces oxidative stress and glutamate release through action on system Xc-. Exp Neurol. 2009 Jun;217(2):429-33.Travis Rush*, Julie Hjelmhaug and Doug Lobner. Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture. Neurotoxicology. 2009 Jan;30(1):47-51.

Performed chemical assays of industrial effluent water samples to determine alkalinity, hardness and chloride content, etc.Acute and chronic toxicity tests of effluent samples using cerio daphnia (water flea) and pimephales promelas (fathead minnow).Shipping & Receiving of effluent sampling kits.

Doctor Of Philosophy (Ph.D.), Neuroscience

Education record

Bachelor Of Science (B.Sc.), Physiology