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Effective strategist, group manager, and cross-functional team leader with scientific expertise in drug discovery for neurodegenerative, neuroinflammatory, and metabolic diseases. >15 years expertise in neurodegeneration research (in vitro and in vivo), assay development, scaling, miniaturization, and application. (primary, iPSC, and cell line models; CRISPR editing)in vitro pharmacology expert, leading a team of 10+, delivering data packages for med chem efforts for NCE and repurpose programs and building the next generation of phenotypic screening tools for neuroscience at Recursion.Preclinical drug development experience; FDA interactions and IND preparation.
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GskUpper Providence, Pennsylvania, United States -
Senior Director Of BiologyRecursion Jun 2023 - Nov 2024Salt Lake City, Utah, Us -
Director Of Biology - NeuroscienceRecursion Nov 2021 - Jun 2023Salt Lake City, Utah, UsPartnering with Senior Leadership to define two delivery anchors spanning multiple departments and cross-functional groups.Leading and Growing a multi-level team to near >15 neuroscientists across four delivery areas.Defining cross-functional strategy and multi-year build of Recursion's Neuroscience Platform.Partnering closely with Senior Leadership / Execs, I'm working to coordinate several departments' efforts to successfully onboard neural cell types to generate Recursion's Map of Human Neurobiology. Recursion's mission is to use maps such as this to Decode Biology and Radically Improve Lives of patients, by expediting Drug Discovery. -
Senior Scientist IiiRecursion Oct 2019 - Nov 2021Salt Lake City, Utah, UsBuilt a functional group, expanding multi-level team from 3 to 9 in less than 3 months..Effective manager and mentor from onboarding new personnel through successful coaching into Bio Leadership roles.Partnered with Director and other Senior Scientist Group Leads to define a new department and plans for the next ~2 year horizon. Strategic Scientific lead helping Executives define Recursion's Neuroscience platform build.Scientific Team Lead and Biology Lead across several prominent programs within Recursion's Pipeline.Effective leader of cross-functional project teams driving drug discovery decisions by coordinating the activities of research staff (direct reports), and teammates from Chemistry, Commercial, Development, In Vivo (PK, ADMET, efficacy studies), and Toxicology departments. -
Research Scientist IiRecursion May 2018 - Oct 2019Salt Lake City, Utah, UsDemonstrated impact on Recursion's drug-discovery portfolio through decision-informing data generation. Cross-functional project leadership. Expanded mentorship role as we built the neuroscience stronghold and hired several Research Scientists and Associates -
Research Scientist - Disease Biology And Cellular PharmacologyRecursion Jul 2017 - May 2018Salt Lake City, Utah, Us -
Postdoctoral FellowThe University Of Alabama At Birmingham Apr 2014 - Jun 2017Birmingham, Al, UsHit-to-lead optimization for a drug discovery program targeting neurodegeneration in Alzheimer's disease. Our target: a novel interaction between the microtubule associated protein, tau, and a kinase important to the synaptic loss underlying disease disease. Studies involved high-content, automated imaging of primary rodent neurons, proximity ligation, immunofluorescence, and routine molecular biology and biochemistry assays. Publications:Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ, McMahon LL, and Roberson ED. Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. (2020) eLife Jul 13;9:e57354Rush T*, Roth JR*, Thompson SJ, Aldaher AR, Cochran JN, and Roberson ED. (2020) A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiol Dis. 134:104668.Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, and Herskowitz JH. (2016) ROCK1 is increased in Alzheimer’s disease and ROCK1 depletion reduces amyloid-β levels in brain. J Neurochem, 138(4):525-31.Cochran JN, Rush T, Buckingham SC, Roberson ED. (2015) The Alzheimer’s disease risk factor CD2AP maintains blood-brain barrier integrity. Hum Mol Genet, 24(23):6667-74. -
Postdoctoral Research AssociateGrenoble Institute Of Neurosciences - Inserm U836 Nov 2011 - Apr 2014Paris, 13, FrPreclinical, in vitro experimentationLive-neuron imaging, biochemistry and molecular biology.Statistical analysis and conclusive interpretation of results. Results dissemination via internationally recognized journals and conferences.Grant preparation, writing and submission.Publications:Rush T*, Martinez-Hernandez J*, Dollmeyer M*, Frandemiche ML, Borel E, Boisseau S, Jacquier-Sarlin M, and Buisson A. (2018) Aβ oligomers induce synaptic impairment by acutely stabilizing the actin cytoskeleton through cofilin phosphorylation. J Neurosci, 38(48):10349-61. Amar F, Sherman MA, Rush T, Larson M, Boyle G, Chang L, Gotz J, Ashe KH, Buisson A, and Lesne SE. (2017) Specific alterations of tau phosphorylation and neuronal signaling induced by the amyloid-β oligomer Aβ*56. Sci Signal, 10(478).Travis Rush*, Alain Buisson. Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral. Cell Tissue Res. 2014, 356(2), 279-86. Review.Marie Lise Frandemiche, Sandrine De Seranno, Travis Rush*, Eve Borel, Auréliane Elie, Isabelle Arnal, Fabien Lanté, Alain Buisson. Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers. J Neurosci. 2014, 34(17), 6084-97.Javier Becerril-Ortega, Karim Bordji, Thomas Fréret, Travis Rush*, Alain Buisson. Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease. Neurobiol Aging. 2014, 35(10), 2288-301. -
Graduate Student ResearcherMarquette University Aug 2006 - Oct 2011Milwaukee, Wi, UsTravis Rush*, XiaoQian Liu, Andrew B. Nowakowski, David H. Petering and Doug Lobner. Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1. Neurotoxicology. 2012 Jun;33(3):476-81.Travis Rush*, XiaoQian Liu and Doug Lobner. Synergistic toxicity of the environmental neurotoxins methylmercury and β-N-methylamino-L-alanine. Neuroreport. 2012 Mar 7;23(4):216-9.XiaoQian Liu, Jon Resch, Travis Rush* and Doug Lobner. Functional upregulation of system xc- by fibroblast growth factor-2. Neuropharmacology. 2012 Feb;62(2):901-6.Travis Rush*, XiaoQian Liu, Julie Hjelmhaug and Doug Lobner. Mechanisms of chorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. 2010 Mar 31;166(3):899-906.XiaoQian Liu, Travis Rush*, Jennifer Ciske and Doug Lobner. Selective death of cholinergic neurons induced by β-N-methylamino-L-alanine. Neuroreport. 2010 Jan 6;21(1):55-8.XiaoQian Liu, Travis Rush*, Jasmine Zapata and Doug Lobner. β-N-methylamino-L-alanine induces oxidative stress and glutamate release through action on system Xc-. Exp Neurol. 2009 Jun;217(2):429-33.Travis Rush*, Julie Hjelmhaug and Doug Lobner. Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture. Neurotoxicology. 2009 Jan;30(1):47-51. -
Bioassay Laboratory Technician (Part-Time, 4-10 Hours/Week)Sf Labs May 2001 - Jun 2005Performed chemical assays of industrial effluent water samples to determine alkalinity, hardness and chloride content, etc.Acute and chronic toxicity tests of effluent samples using cerio daphnia (water flea) and pimephales promelas (fathead minnow).Shipping & Receiving of effluent sampling kits.
Travis Rush Skills
Travis Rush Education Details
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Marquette UniversityNeuroscience -
University Of Alabama At Birmingham -
Marquette UniversityPhysiology
Frequently Asked Questions about Travis Rush
What company does Travis Rush work for?
Travis Rush works for Gsk
What is Travis Rush's role at the current company?
Travis Rush's current role is Drug Discovery and Group Leadership.
What is Travis Rush's email address?
Travis Rush's email address is tr****@****uab.edu
What is Travis Rush's direct phone number?
Travis Rush's direct phone number is +180158*****
What schools did Travis Rush attend?
Travis Rush attended Marquette University, University Of Alabama At Birmingham, Marquette University.
What skills is Travis Rush known for?
Travis Rush has skills like Neuroscience, Neurotoxicology, Tissue Culture, Confocal Microscopy, Live Cell Imaging, In Vitro Toxicology, Molecular And Cellular Biology, Algorithms, Statistical Data Analysis, Computer Science, Heavy Metals, Pesticides.
Who are Travis Rush's colleagues?
Travis Rush's colleagues are Arpit Dixit.
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