Trevor Stack Email & Phone Number

Cambridge, Ma, Us

Cambridge, Ma, Us

Cambridge, Ma, Us

Working to rationally optimize, scale, and tech transfer high quality GMP ready processes

Tokyo, Jp

Working at the intersection of discovery and early process development. Developing novel cell lines and iPSC gene engineering processes with an eye towards scale up using a QbD and DOE approach. Cell therapy process development. Novel technologies evaluation. Working to evaluate and understand novel technologies and how they can impact and improve platform processes.

Tokyo, Jp

Process development on novel cell therapy platforms and gene engineering process development for iPSCs and iPSC related products

Evanston, Il, Us

• Developed novel translational targeted nanoparticle drug delivery method for treatment of glaucoma leading to 2 first author peer-reviewed publicationso Collaborated with researchers across 4 institutions including tech and material transfer• Quantified nanoparticle encapsulation efficiency through development of novel HPLC, GPC, and cell based methods specifically designed to work for Scott Lab polymeric PEG-b-PPS Nanoparticles• Developed novel macropinocytosis inhibitory nanoparticles for enhancement of “chase” nanoparticle circulation time and target tissue accumulation leading to 1 first author publicationo Characterized micelle formulations utilizing TEM, DLS, Flow cytometry, AFM, and in vitro cell based assays. o Evaluated altered biodistribution in healthy and tumor in vivo mouse models using flow cytometryo Quantified survival rate changes of functional therapies paired with macropinocytosis inhibitory nanoparticleso Utilized flow cytometry and confocal microscopy to evaluate immune cell subsets in various organs• Developed novel, modular ‘lipid tail insertion’ method of nanoparticle surface modification enabling enhanced control over ligand surface density o Utilized QbD principle and design expert DOE software to optimize multiple ligand surface densities• Lead patent harvesting session leading to invention disclosure and potential patents prior to public disclosureo 2 disclosures related to macropinocytosis inhibitory nanoparticles and targeted nanoparticles for glaucoma• Managed and organized labwide flow cytometry panels for analysis of immune cell subsets in mice• Developed immortalized and non-immortalized cell banks and cell banking protocols for the Scott lab• Mentored 2 Master’s students and 2 undergraduate students through guided research projects across 3 years resulting in successful fulfillment of master’s theses and undergraduate research goals.

• Developed ELISA assays for analysis and evaluation of mouse responses to nanoparticle vaccine formulations• Established and validated methods for multiplexed analysis of multiple cytokines from mouse serum• Managed a team of 3-4 people to efficiently execute and analyze 30-40 ELISA assays dailyo Coordinated with other teams and departments to ensure a streamlined process with fast, accurate data analysis• Assisted with In Vivo experiments evaluating novel nanoparticle based vaccine formulations

Canton, Massachusetts, Us

Product Development Engineer.• Developed robust functional assays to evaluate product candidates with a focus on immunomodulatory assays.• Coordinated cross-functional team to prepare product candidates for pre-clinical large animal studies. • Established new cell banking methods and banked cells using traditional and new techniques.• Developed cell screening assays to assess quality of cell banks• Developed new manufacturing processes to improve product quality and shelf life. • Utilized Design Expert to execute multivariable DOEs using QbD principles• Pre-validated several assays for transfer to QC to satisfy FDA post-marketing requirements • Managed ‘Biotech Blog’ for R&D. Facilitated quarterly round table discussions amongst the department as well as posting schedule and content. • Maintained laboratory equipment and stocks

Boston, Ma, Us

Ultrasound Image registration of images from different time points for a cervical length study.Created 3D solid models from ultrasound images using solid works. Used finite element analysis to determine effect of pressure on cervical length.