Ursula Ramirez Email & Phone Number

Philadelphia, PA, US

Troy, Michigan, US

• Writing/Management:
• Designed, wrote and edited 3-5 Phase I or Phase II SBIR grants per year.
• Negotiated, wrote, and edited contracts and license agreement
• Developed and presented company pitches for investors and local and national meetings
• Maintained company website and directed company promotion
• Developed academic and industry collaborations to augment internal research capabilities

• Directed Clinical Research at two sites for Clinical Pediatric Practice
• Directed all activities for two sites from site selection through Final closeout for 5 studies
• Participated in initiation and investigator meetings and reviews with sponsor, IRB, clinical research associates and CROs.
• Reviewed protocols and guided selection of studies
• Wrote and maintained source documentation, EDC, IRB, and sponsor reports, site-specific training and patient recruitment advertising
• Trained site personnel on protocols and study execution and documentation

Philadelphia, PA, US

• Crystallized and solved multiple structures of porphobilinogen synthase (PBGS) and phenylalanine hydroxylase (PAH), and identified novel small molecule modulators of Epidermal Growth Factor Receptor (EGFR) by in silico.
• Identified novel small molecule modulators by virtually docking small molecule libraries to EGFR and PBGS models using Glide, developing selection criteria PERL scripts, then performing in vitro testing
• Contributed structural guidance for SAR to medicinal chemists for hit to lead optimization
• Crystallized PAH and solved and manually refined first structure of full-length PAH at low-resolution
• Prepared manuscripts for publication and crystal structure files for deposition to the RCSB PDB
• Directed multiple students in co-crystallizing various proteins with different effector molecules

Philadelphia, PA, US

• Discovered species-specific modulators of porphobilinogen synthase (PBGS) by homology modeling, in silico docking, applying selection criteria through PERL scripts, and in vitro testing
• Contributed structural guidance for SAR to medicinal chemists for hit to lead optimization
• Built homology models of PBGS from several species and trypsin using MolIDE and/or Prime
• Crystallized PAH and solved and manually refined first structure of full-length PAH at low-resolution
• Crystallized and solved multiple high resolution structures of PBGS in different binding states with various effector molecules.
• Prepared manuscripts for publication and crystal structure files for deposition to the RCSB PDB

Chicago, IL, US

• Crystallized, harvested crystals, collected and processed synchrotron data of signal recognition particle fifty-four homologue (Ffh) and h-Ras.
• Phased, refined and built multiple ultra-high resolution protein structures.
• Analyzed crystal packing, water structure, and nucleotide binidng at ultra-high resolution.
• Expressed, purified and crystallized the GTPase domain of h-Ras.
• Prepared manuscripts for publication and presented data at local and national meetings

Randolph AFB, TX, US

• Developed software and hardware design for new test development system
• Evaluated and prioritized acquisition proposals for $1 million budget
• Performed systems analysis for the automation of manual test development process
• Designed data model and developed high-level design of software and hardware for automation
• Served as management liaison among departments involved in system development and use
• Wrote requirements and evaluated contract proposals for wiring and network components

Doctor Of Philosophy (Phd), Structural Biology

Bachelor Of Science (Bs), Experimental Psychology