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I like biopharmaceutical manufacturing and the science and engineering that is needed to develop products, processes, and organizations to turn a promising drug candidate into a drug product with a safety, an efficacy, and a production cost that allows it to reach the intended patients.I learned the importance of proper development to turn a candidate into a product and create Chemistry, Manufacturing and Control (CMC) programs appropriate for the different phases of clinical studies or for commercialization.I had the opportunity to work on wide variety of products in different phases of (clinical) development: recombinant proteins, viral vectors, vaccines, and cell therapies, using animal cells and/or microbes to produce these. To allow these products to be used in humans they must be produced in a Good Manufacturing Practices (GMP) compliant environment, and I did technology transfers from Research and Development to Manufacturing working for an R&D team or working for a manufacturing team.I was involved as expert in GMP facility and equipment design, participated or led their commissioning, validation, and start-up and implemented quality systems.I learned a lot from the people I work(ed) with, and I led, hired, managed, trained and/or mentored co-workers. I like sharing my experience and knowledge through training and lectures.
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Vice President, Technical OperationsHypermabs Inc. Jul 2023 - PresentHyperMabs is a biopharmaceutical company that designs and developsinnovative monoclonal antibody-based therapeutics for life threateningdiseases. -
Vice President ManufacturingExcellthera Nov 2021 - May 2023Montreal, Quebec, CanadaExCellThera is a clinical stage cell and molecular medicine company delivering molecules andbioengineering solutions to expand stem and immune cells for use in novel curative therapies forpatients with hematologic malignancies.▪︎ Preparing a CMC package for commercial submission of a cell-therapy product.▪︎ Supporting clinical production. -
R&D Director Bioprocess Engineering Department, Human Health TherapeuticsNational Research Council Canada / Conseil National De Recherches Canada Dec 2015 - Nov 2021Montreal, Canada AreaNRC's Human Health Therapeutics research centre works hand in hand with industry to help biotech firms achieve success and save costs. As an R&D partner of choice, NRC‑HHT de‑risks critical steps in the development of biologics, vaccines and immunotherapeutics, and delivery of large molecules to the brain, to help improve the health of Canadians. Responsible for the Bioprocess Engineering department (up to 135 researchers):▪︎ Expression and production of large molecules such as antibodies and viral vectors.▪︎ Process development and scale-up of the associated microbial and animal-cell based processes.▪︎ Purification of the products to a level where the process is suitable for transfer to a cGMP manufacturing organization. -
Section Head Process Development And Scale-UpNational Research Council Canada Apr 2015 - Nov 2021Montreal, Canada AreaThe Process Development and Scale Up team is engaged in a number of ongoing research services and collaborations with numerous biopharmaceutical companies to advance the development of their biologics and vaccines. Customized solutions are developed in partnership with our clients and collaborators, who work side-by-side with our scientists to ensure efficient technology transfer. -
Consultant Biotechnology/Pharmaceutical ProcessingFrank Van Lier Consultancy 2009 - Apr 2015Montreal, Canada AreaMain mandates:Involved with design, construction and start-up of the Centre d'excellence en thérapie cellulaire (CETC) of the Hôpital Maisonneuve-Rosemont.Quality Assurance manager for a veterinary vaccine company.Quality consultant for the National Research Council.
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Senior Director R&D / Site Manager MontrealKiadis Pharma 2008 - 2009Saint-Laurent, CanadaKiadis focuses on the R&D of cell therapeutics.▪︎ Process development.▪︎ Support clinical trials.▪︎ Managing of the Montreal site.
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Bioprocess SpecialistLaporte Consultants 2006 - 2008Montreal, CanadaLaporte provides high value-added engineering services to pharmaceutical, agrifood and bioindustrial plants.▪︎ Conceptual and detailed design of process equipment and facilities.▪︎ Main projects: pharmaceutical pilot plant and microbial vaccine production facility. -
Director Operations Laboratoire De Biotechnologie Vétérinaire Et AlimentaireUniversité De Montréal 2005 - 2006Saint-Hyacinthe, CanadaThe Laboratoire de biotechnologie vétérinaire et alimentaire was intended as a GMP compliant production unit.▪︎ Setting up operations for production and development.▪︎ Validation of building and building systems.▪︎ Validation of process equipment for production in microbial and animal-cell platforms. -
Senior Scientist And Manager Positions Within Operations DepartmentDsm Biologics 1997 - 2005Montreal, CanadaDSM Biologics was a contract manufacturing organization for biological products.▪︎ Production of recombinant proteins up to 2000 scale.▪︎ Process transfer and process development.▪︎ Fed-batch and perfusion production. -
Fermentation SupervisorGist-Brocades / Bio-Intermediair 1994 - 1996Groningen, NetherlandsBio-Intermediair was a start-up company and a contract manufacturer for the biopharmaceutical industry located in The Netherlands and in Canada.▪︎ Start up GMP production.▪︎ Process transfer and production rec. proteins and vaccine.▪︎ Microbial and animal-cell platforms.▪︎ Batch, fed-batch and perfusion production.
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Bioprocess EngineerBiocat Foundation 1992 - 1993Groningen, NetherlandsThe BioCat foundation had as mandate to develop biotechnology in the province of Groningen in The Netherlands.▪︎ Implementation of GMP Quality System at a CMO.▪︎ Validation of equipment and building systems.
Frank Van Lier Skills
Frank Van Lier Education Details
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Bioprocess Engineering, Molecular Sciences
Frequently Asked Questions about Frank Van Lier
What company does Frank Van Lier work for?
Frank Van Lier works for Hypermabs Inc.
What is Frank Van Lier's role at the current company?
Frank Van Lier's current role is VP Technical Operations | CMC expert.
What is Frank Van Lier's email address?
Frank Van Lier's email address is va****@****ail.com
What is Frank Van Lier's direct phone number?
Frank Van Lier's direct phone number is (613)-990*****
What schools did Frank Van Lier attend?
Frank Van Lier attended Wageningen University & Research.
What skills is Frank Van Lier known for?
Frank Van Lier has skills like Pharmaceutical Industry, R&d, Biopharmaceuticals, Fermentation, Documentations, Training, Biotechnology, Sop, Start Ups, Product Development, Fda, Gmp.
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Frank van Lier
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