• A highly motivated and target-driven professional with 8 years of expertise in molecular and cell biology research, specializing in developing oligonucleotide candidates (aptamer, siRNA, saRNA) for immuno-oncology, neurodegenerative diseases, liver indications, and targeted cancer therapy.• Proficient in leading multifaceted projects with strong multitasking and problem-solving abilities. Skilled in chemical synthesis and analytical characterizations of oligonucleotides. Solid background in cell- and protein-based chemical biology assays. Extensive exposure to nanoparticle/polymer analysis and animal works.• A proactive leader in inspiring projects, maintaining lab and mentoring young scientists. Proven track record of independent and collaborative research, resulting in 2 patents and 21 publications in high-impact journals.SKILLS• Highly proficient in chemical synthesis: DNA synthesis and purification, RNA in vitro transcription, Surface modification, Aptamer development, Polymerization, Conjugation chemistry, Lipid/Nanoparticle modification.• Highly experienced in analytical and chemical biology techniques: HPLC, UV-Vis, DLS, Fluorescence spectrometry, Octet, SPR, TEM DNA/RNA/Protein extraction, Real-time PCR (RT-PCR), PCR, ELISA, Colorimetric protein assays, Gel electrophoresis, EMSA, MSD, FRET, Western blotting, Size-exclusion/Affinity chromatography, Systematic Evolution of Ligands by EXponential Enrichment (SELEX), Electrochemiluminescence (ECL), Pseudovirus neutralization assay.• Strong expertise in cell-based studies: Cell culture, Cell transfection, Stable cell line generation, Cell viability assays (MTS/MTT), Human and mouse primary hepatocytes (PHH, PMH), Hepatocyte isolation, Flow cytometry (FACS), Confocal microscopy.• Hands-on experience in nanoparticle and polymer chemistry, and animal model studies (animal anatomy, Cryostat, in-vivo imaging).
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Technical EngineerVidyardiHyderabad, In -
Senior ScientistOlix Pharmaceuticals, Inc. Jan 2015 - Aug 2021• Led the establishment of immunotyping panels of tumor-infiltrating lymphocytes (TIL) and immune suppressor cells, investigated variations in the number and repertoire for the study of proprietary RIG-I and MDA5 agonist dsRNA. • Identified and validated leading small activating RNAs (saRNA) for upregulating human and mouse target gene expression in hepatic disorder treatment. Evaluated GalNAc conjugation for mouse saRNA delivery and in vivo target activation. Collaborated with Harvard BIDMC.• Identified top human & NHP siRNAs with significant target gene knockdown for hereditary angioedema (HAE) treatment.• Managed lab relocation, reorganization and setup at Lexington. Trained and supervised research associates within the R&D team. -
ScientistOlix Pharmaceuticals, Inc. Oct 2010 - 2014 -
Associate Scientist IDicerna Pharmaceuticals, Inc. Aug 2006 - Jul 2009 -
Senior Research AssociateDicerna Pharmaceuticals, Inc. Feb 2004 - Aug 2006 -
Research AssistantChina Pharmaceutical University Sep 2002 - Jan 2004• Assisted in the evaluation of the mutated polypeptide Cbf-K16 in cell and animal studies.• Obtained new anti-tumor candidates based on inhibitors for tumor angiogenesis and tubulin.
Vasanth Reddy Education Details
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Bachelor Of Science - Bs, Pharmaceutical Sciences -
Doctor Of Philosophy - Phd, Chemistry
Frequently Asked Questions about Vasanth Reddy
What company does Vasanth Reddy work for?
Vasanth Reddy works for Vidyardi
What is Vasanth Reddy's role at the current company?
Vasanth Reddy's current role is Technical Engineer.
What schools did Vasanth Reddy attend?
Vasanth Reddy attended Jawaharlal Nehru Technological University Kakinada (Jntuk), China Pharmaceutical University, University Of Florida.
Who are Vasanth Reddy's colleagues?
Vasanth Reddy's colleagues are Sravan Saiba, Shekar B, Bandi Kotesh, Chandra Mamdabad, Yazhini B, Praneeth Reddy, Rushmitha Chowdary.
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Vasanth Reddy
Bengaluru -
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