• Develop research projects aimed at using MSCs and their extracellular vesicles for tissue repair/immunomodulation• Examine the role of autophagy in MSC maintenance and rejection• Examine the effect(s) of autophagy modulation on molecular and functional properties of MSC exosomes

• Develop research projects aimed at using MSCs and their extracellular vesicles for tissue repair/immunomodulation• Examine the role of autophagy in MSC maintenance and rejection• Examine the effect(s) of autophagy modulation on molecular and functional properties of MSC exosomes

• Develop research projects aimed at using stem cells for cardiac tissue regeneration and age-related macular degeneration• Coordinate research efforts between Karolinska Institutet and Vaccine and Gene Therapy Institute• Manage post-doctoral fellows and research specialists

• Evaluated adjuvant properties of RNAs in influenza vaccines;• Evaluated adaptive and innate immune responses to vaccination• Evaluated anticancer properties of oncolytic viruses in combination with small molecules• Performed systems biology analysis of therapeutic combinations

• Evaluated antitumor mechanism for an experimental cancer therapeutic using cell-based assays, ex-vivo tissues and in vivo rodent models, confocal microscopy, immunohistochemistry, flow cytometry and various apoptotic assays• Evaluated autophagy stimulation/inhibition for anticancer therapy• Optimized therapeutic regiments for kinase inhibitors alone or in combination with standard-of-care therapies in mouse tumor models• Developed and validated pharmacodynamic biomarkers for kinase inhibitors by HPLC separation/quantification of sphingosine1-phosphate in blood• Optimized fluorescent assays and performed high-throughput screenings for small molecules inhibitors using microplate readers; managed libraries of compound and deconvoluted screening data

• Biochemically and genetically characterized a knockout mouse model of an ABC drug-transporter protein using immunohistochemistry, RT-PCR, genotyping and western blot analysis• Maintained and genotyped transgenic mouse colony• Studied protein-protein interactions by yeast two-hybrid assay and immunoprecipitation• Identified drug-resistance phenotypes using apoptotic and cytotoxicity assays in ex-vivo tissues and established cell lines

• Studied mechanisms that mediate sensitivity of eukaryotic cells to DNA-crosslinking drugs using eukaryotic genetic models representing genetic instability of cancer cells• Cloned, overexpressed in bacteria and yeast and purified protein fragments for crystallographic analysis• Characterized cisplatin analogs-DNA adducts in order to elucidate structure-activity relationship for platinum drugs using radioactive labeling, gel electrophoresis, HPLC and mass spectrometry

• Synthesized, purified and establish structures by NMR and crystallography of usnic acid derivatives and corresponding metal complexes and studied their antibacterial properties