Bala M.K. V Email & Phone Number

Hyderabad, Telangana, India

South Korea

Toxicological assay development and validation (Mammalian, Non-mammalian, enzymatic, and molecular).Managing several aquatic and terrestrial ecotoxicological experiments for pesticide screeningRNAseq technology-based exploration of the toxicological mechanisms.Mentoring graduate students/junior staff members in the design, optimization, and implementation of experiments and work methods.Responsible for writing project proposals, project management, maintaining accurate research records, and providing research strategies and recommendations.

South Korea

Worked on pig-primate cardiac xenotransplantation: Immune rejection, genotyping,Identified potential molecular mechanisms of early-failed cardiac xenograft (pig-monkey).Validated mPEA15 expressing transgenic pig as a potential diabetes model.Molecular cloning, NGS data validation, primary cell lines, serum analysis, and scientific writing.

South Korea

In-Vitro Diagnostics (IVD): Recombinant Protein Expression and Purification, and Immunoassays.Developing Enzymatic Assays on a Droplet-based Microfluidic Platform.

South Korea

Managed the project "Investigation of the exact molecular role/function of VIG-1 in DNA repair and genome stability".Developed methodologies for measuring VIG-1 expression in nematodes (Spatiotemporal)

South Korea

Major project 1: Design and development of biological assays on Droplet-based microfluidics. -Developed four enzymatic assays (RNase, DNase, and Phosphatase, Angiogenin) on a Droplet-based Microfluidics platform. -Carried out cloning and optimized the protein expression and protein purification of Anigiogenin and Phosphatase (DUSP22).Major project 2: Investigation of the role of Muscarinic acetylcholine receptor in colon cancer cell proliferation. -Reported the role of muscarinic acetylcholine receptor in global protein biosynthesis and colon cancer cell proliferation. -Reported that muscarinic receptors influence the protein synthesis via ERK/mTORC1, eEF2k, eEF2, 4EBP1, and eIF4b.Major project 3: Investigation of reasons behind abnormal phenotypes of vig-1 mutants. -Identified VIG-1 as a component of genome stability/DNA repair in C.elegans.

Bangalore

Developed several cell-based assays for target validation and for the screening of anti-diabetes drugs.Played a leading role in the development of CYP induction assay for NCEs screening. Played an important role in the development of an in-vitro assay platform for the screening of antifibrotic drugs. Measured drug uptake of several cell lines on the LC-MS-MS platform.Performed the physiological, molecular, and biochemical analysis of mice models.Mentored a group of 2-3 scientists in molecular biology and mammalian cell culture techniques.Published three manuscripts in peer-reviewed international journals.

Bangalore

Developed, screened, and characterized Arachis hypogaea and Cicer arietinum transgenic plants (BT crops).Performed Biotic and Abiotic stress experiments (Chickpea, Pigeonpea, Peanut, Rice, and Cotton).Cloned multi-genes constructs harboring cry genes.Performed Gene expression studies and immunoblotting.Involved in plant tissue culture and insect bioassays experiments.

Nasik Area, India

Kakinada Area, India

Delivered lectures on Histopathology and Microbiology courses, instructed students on how to conduct laboratory experiments and evaluated grades, class assignments, and laboratory work for a group of 30 Medical Lab Technician (MLT) students.

Phd, Biochemistry & Molecular Biology, A+

Master'S Degree, Biotechnology, A

Pg Diploma, Bioinformatics, A

Bachelor'S Degree, Chemistry, Biochemistry, Biotecnology, A