• Delivered data for companion diagnostic submission by leading selection and set-up of laboratories in Europe and China to deliver phIII analysis to challenging timelines • Successful issue resolution of scoring drift during an ongoing phII clinical trial• Provided technical input into delivery of FISH and IHC IUO assays in partnership with DAKO and Ventana.• Project management of collaborations with academic institutes to deliver biomarker research data• Performed FISH and IHC… Show more • Delivered data for companion diagnostic submission by leading selection and set-up of laboratories in Europe and China to deliver phIII analysis to challenging timelines • Successful issue resolution of scoring drift during an ongoing phII clinical trial• Provided technical input into delivery of FISH and IHC IUO assays in partnership with DAKO and Ventana.• Project management of collaborations with academic institutes to deliver biomarker research data• Performed FISH and IHC laboratory analysis for exploratory biomarker studies within the principles of GCP• Delivery and implementation of SOPs, best practise documents, and quality plans to ensure consistency of processes• Training of key drug sales account managers for Lynparza, Iressa and Tagrisso to promote a solid understanding of the diagnostic methods used for patient selection Show less

• Design, production, optimisation and verification of FISH assays and application of lab developed tests to key clinical projects for example RET FISH analysis for Vandetanib (Platt, A et al 2015) • Successfully concluded project evaluating cell free DNA (cfDNA) and exosomal RNA as a potential method for analysis of liquid biopsies in collaboration with Exosome Dx• Established miRNA array and FISH capabilities enabling several translational science projects• Evaluated Affymetrix… Show more • Design, production, optimisation and verification of FISH assays and application of lab developed tests to key clinical projects for example RET FISH analysis for Vandetanib (Platt, A et al 2015) • Successfully concluded project evaluating cell free DNA (cfDNA) and exosomal RNA as a potential method for analysis of liquid biopsies in collaboration with Exosome Dx• Established miRNA array and FISH capabilities enabling several translational science projects• Evaluated Affymetrix Oncoscan arrays for mutation and copy number analysis of FFPE DNA samples.• Successfully led MLPA analysis of copy number variation in LQTS patients, presented work at North-West Pharmacogenetics Research Network meeting (Williams, V et al 2015) Show less

• Development and verification of mutation specific Amplification Refractory Mutation System (ARMS) assays• Worked within GCP environment with LIMS system to provide DNA samples• Biomarker analysis of tumour samples, explants, and cell lines for example by sequencing, qPCR, CGH, ARMS• Performed sequencing and bioinformatics analysis of polymorphisms to determine common sequence and variants in targets for lead optimisation and high throughput screening• Developed protocol for… Show more • Development and verification of mutation specific Amplification Refractory Mutation System (ARMS) assays• Worked within GCP environment with LIMS system to provide DNA samples• Biomarker analysis of tumour samples, explants, and cell lines for example by sequencing, qPCR, CGH, ARMS• Performed sequencing and bioinformatics analysis of polymorphisms to determine common sequence and variants in targets for lead optimisation and high throughput screening• Developed protocol for extraction of cf-DNA and performed whole genome amplification on plasma in order to do genotyping analysis on limited clinical samples. Show less