Vikas Chandra Email and Phone Number
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Experienced biopharmaceutical professional and innovator with over 20 years of subject matter expertise in regulatory compliant downstream process development and manufacturing science and technology (MSAT). Proven scientific and technical leadership skills in building and managing teams of scientists, engineers and technical staff both in downstream PD and cGMP manufacturing. Specialties: Downstream Process Development, Process Characterization, Validation, Scale-up, MSAT, Tech. Transfer, SOPs, Batch Records, Regulatory documents, cGMP manufacturing.Multiple publications in esteem journal such as Nature.
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Head Of Downstream Process DevelopmentAdvanced Biosciences Laboratories, Inc. / Biomerieux Jan 2018 - PresentFocus: Development of robust, cost effective, scalable downstream bio-processes and technology transfer. • Managing and supervising teams of scientists, engineers and technical staff focused on developing novel, efficient, scalable and transferable downstream processing and technologies to manufacturing facilities for both for Government and commercial clients. • Expertise in downstream operations including harvest, clarification, chromatography, filtration, viral clearance, formulations, optimization, risk assessments and mitigation, strategic planning, budgeting etc.• Experience in scale-down model validation and process characterization studies towards product development for commercialization. Drafting and review of tech reports and regulatory documents.• Cross functional management/collaborations with upstream, analytical, QC, QA, cGMP, vendors, project management, regulatory agencies, and clients for timely execution and delivery of bioprocesses. • Demonstrated history of successful development and delivery on multiple projects involving recombinant proteins, antibodies and in particular challenging viral vectors such as Vaccinia, Chikungunya, Zika, Ebola, Dengue, YFV, VLPs, Polio, HCMV, HIV, Myxo, AAVs etc. -
Senior Staff ScientistSanford Burnham Prebys Medical Discovery Institute Jul 2010 - Dec 2017La Jolla, Ca, UsFocus: Downstream Process development & Preclinical drug discovery on Nuclear Receptors & Viral vectors. • Downstream process development/Scale-up/Characterization/HTP-screenings/Assay development for various drug targets such as RARβ-RXRα, HNF4α, REV-ERBS, ERRs, PR, ER, RORs, LXR, RXR, NURR1, NOR1, NCOAs, HIF-ARNT and also for VLPs, Antibodies, AAVs as potential IND candidates.• Oversee bench and pilot scale process development activities in protein production core facility.• Directed scientific and management strategy for process design, optimization, characterization, statistical analysis, process validation, tech. transfer and regulatory submission for multiple programs.• Proven success in building and leading high-performing teams to advance projects to timely completion.• Discovered the allosteric regulatory mechanism in nuclear receptors through inter-domain signal transmission (Nature 495). Opened a new approach of drug targeting in pharmacologically significant nuclear receptors by directing therapeutic molecules to sensitive inter- junctional sites (Nature Communications 8). -
Scientist/Instructor/Research AssociateUniversity Of Virginia Health System Mar 2003 - Jun 2010Charlottesville, Virginia, UsFocus: Expression, Purification, Characterization & Structure-function studies on nuclear receptors• Developed downstream processes producing milligrams to grams scales of ultra-purified biologics supporting structure based drug design program and pre-clinical studies.• Successfully expressed and purified difficult drug target proteins: full length Human Estrogen Receptor (hER), Retinoic acid Receptor (RAR), Farnesoid X Receptor (FXR), Peroxisome proliferator activated receptor (PPAR), Glucocorticoid Receptor (GR), Androgen receptor (AR) etc.• Adept in managing resources and bringing innovation along with implementing state of the art downstream process technology.• Revealed the monumental first crystal structure of intact PPARγ-RXRα-DNA heterodimer. This rare accomplishment was achieved by innovative downstream process development of the complex. Enabling a new path for scientists to design drugs more rationally and with higher efficacy (Nature 456). -
Principal InvestigatorAll India Institute Of Medical Sciences Jul 2000 - Jan 2003New Delhi, Delhi, InFocus: Process development and Structure based drug design on Phospholipase A2 inhibitors for therapeutics• Effectively managed and mentored biochemists, chemists, associates at BS/MS/PhD levels.• Supervised development of purification processes for macromolecules heterocomplexes involving other proteins, peptides, small molecules with specific stoichiometry (J. Biol. Chem. 277 & Acta Cryst. D58).• Hitherto obscure design rules for PLA2 inhibitory mechanism were postulated based on crystal structures of PLA2 in complex with Vitamin E (J. Mol. Biol. 320) and Aristolochic acid (Biochemistry 41). • Excellent communication, technical writing and troubleshooting skills.
Vikas Chandra Skills
Vikas Chandra Education Details
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University Of VirginiaPostdoctoral Associate -
All India Institute Of Medical SciencesBiochemistry And Biophysics -
Indian Institute Of Technology, RoorkeeBiotechnology
Frequently Asked Questions about Vikas Chandra
What company does Vikas Chandra work for?
Vikas Chandra works for Advanced Biosciences Laboratories, Inc. / Biomerieux
What is Vikas Chandra's role at the current company?
Vikas Chandra's current role is Head of Downstream Process Development.
What is Vikas Chandra's email address?
Vikas Chandra's email address is vi****@****ail.com
What schools did Vikas Chandra attend?
Vikas Chandra attended University Of Virginia, All India Institute Of Medical Sciences, Indian Institute Of Technology, Roorkee.
What skills is Vikas Chandra known for?
Vikas Chandra has skills like Sec, Microdialysis, Pas, Seeding, Screening, Poised, Chemical, Diffusion, Cell Biology, Model Building, Drops, A2.
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